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- W3080188481 abstract "The modern world has no available drugs for the treatment of enteroviruses (EV), which affect millions of people worldwide each year. The EV71 is a major causative disease for hand, foot, and mouth disease; sometimes it is associated with severe central nervous system diseases. Treatment for enteroviral infection is mainly supportive; treatment for aseptic meningitis caused by enteroviruses is also generally symptomatic. Upon the urgent request of new anti-enterovirus drugs, a series of hinged aromatic compounds with polynulei were synthesized through two different chemical pathways. Among these morpholine–furan/thiophene/pyrrole–benzene–pyrazole conjugates, three new agents exhibited inhibitory activity with EC50 = 2.29–6.16 μM toward EV71 strain BrCr in RD cells. Their selectivity index values were reached as high as 33.4. Their structure–activity relationship was deduced that a thiophene derivative with morpholine and trifluorobenzene rings showed the greatest antiviral activity, with EC50 = 2.29 μM." @default.
- W3080188481 created "2020-09-01" @default.
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- W3080188481 date "2020-08-22" @default.
- W3080188481 modified "2023-09-30" @default.
- W3080188481 title "Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei" @default.
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- W3080188481 doi "https://doi.org/10.3390/molecules25173821" @default.
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