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- W3080192893 abstract "1162 We have previously identified a gene expression signature that predicts relapse of Wilms tumor with high accuracy. C/EBPbeta, one of the few prognostic genes in the signature, is expressed at higher levels in primary relapsing tumors and metastatic tumors than in primary non-relapsing tumors as shown by transcript profiling and immunohistochemical staining. Our observations, together with its up-regulation/hyper-activation in a number of other human cancers and its role as a critical component in a Ras-dependent transformation pathway, suggest that C/EBPbeta may play an important role in Wilms tumor progression. Using siRNA approach, we knockdowned C/EBPbeta expression in Wit49 cells, a cell line derived from a metastatic Wilms tumor, and observed a concomitant increase in spontaneous apoptosis. Caspase assay was performed to distinguish between intrinsic and extrinsic pathways of apoptosis and to assess the caspase inhibitory effect of C/EBPbeta in Wit49 cells. In addition, to determine whether the transcription regulatory function of C/EBPbeta is important for Wilms tumor cell survival, we searched for its downstream target genes. cDNA microarrays were used to examine the gene expression differences between Wit49 cells treated with C/EBPbeta and control siRNAs. Our results indicate that C/EBPbeta is not only a prognostic marker for Wilms tumor, but also a critical survival factor for Wilms tumor cells. Thus it may be a target for anti-tumor therapeutics." @default.
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- W3080192893 date "2004-04-01" @default.
- W3080192893 modified "2023-09-24" @default.
- W3080192893 title "C/EBPbeta contributes to patient prognosis and survival of Wilms tumor cells" @default.
- W3080192893 hasPublicationYear "2004" @default.
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