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- W3080211743 abstract "This chapter highlights how the directed evolution of biocatalysts has delivered impact for GlaxoSmithKline (GSK), and contextualises this in the active pharmaceutical ingredients (API) manufacturing and drug development environment, enabling understanding of the timelines required to deliver a robust and manufacturable biocatalytic process. It provides examples of success stories in implementing directed evolution at GSK, and discusses the hurdles currently associated with embedding biocatalysis and how the process may be further accelerated. To understand how biocatalysis fits into the pipeline, knowledge of the drug development process is required. The journey from small-molecule screening to commercialisation of a medicine starts with target selection and validation. GSK has a significant number of panels, produced both internally and acquired from external sources, which are continuously enhanced through evolution and addition of new enzyme classes. New enzyme panels are assembled using a diverse set of enzymes which have been identified through previously demonstrated activities or using predictive tools." @default.
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- W3080211743 date "2020-08-21" @default.
- W3080211743 modified "2023-09-27" @default.
- W3080211743 title "Directed Evolution of Enzymes Driving Innovation in <scp>API</scp> Manufacturing at <scp>GSK</scp>" @default.
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- W3080211743 cites W1985748743 @default.
- W3080211743 cites W1986056153 @default.
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- W3080211743 cites W1995936058 @default.
- W3080211743 cites W2008708467 @default.
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- W3080211743 doi "https://doi.org/10.1002/9781119487043.ch1" @default.
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