FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080212115> ?p ?o ?g. }

• W3080212115 endingPage "967" @default.
• W3080212115 startingPage "960" @default.
• W3080212115 abstract "Bacterial toxins signaling through Toll-like receptors (TLRs) are implicated in the pathogenesis of many inflammatory diseases. Among the toxins, lipopolysaccharide (LPS) exerts its action via TLR-4 while lipoteichoic acid (LTA) and bacterial lipoproteins such as Braun lipoprotein (BLP) or its synthetic analogue Pam3CSK4 act through TLR-2. Part of the TLR mediated pathogenicity is believed to stem from endogenously biosynthesized platelet-activating factor (PAF)- a potent inflammatory phospholipid acting through PAF-receptor (PAF-R). However, the role of PAF in inflammatory diseases like endotoxemia is controversial. In order to test the direct contribution of PAF in TLR-mediated pathogenicity, we intraperitoneally injected PAF to Wistar albino mice in the presence or absence of bacterial toxins. Intraperitoneal injection of PAF (5 μg/mouse) causes sudden death of mice, that can be delayed by simultaneously or pre-treating the animals with high doses of bacterial toxins- a phenomenon known as endotoxin cross-tolerance. The bacterial toxins- induced tolerance to PAF can be reversed by increasing the concentration of PAF suggesting the reversibility of cross-tolerance. We did similar experiments using human platelets that express both canonical PAF-R and TLRs. Although bacterial toxins did not induce human platelet aggregation, they inhibited PAF-induced platelet aggregation in a reversible manner. Using rabbit platelets that are ultrasensitive to PAF, we found bacterial toxins (LPS and LTA) and Pam3CSK4 causing rabbit platelet aggregation via PAF-R dependent way. The physical interaction of PAF-R and bacterial toxins is also demonstrated in a human epidermal cell line having stable PAF-R expression. Thus, we suggest the possibility of direct physical interaction of bacterial toxins with PAF-R leading to cross-tolerance." @default.
• W3080212115 created "2020-09-01" @default.
• W3080212115 creator A5013722163 @default.
• W3080212115 creator A5015958986 @default.
• W3080212115 creator A5032644073 @default.
• W3080212115 creator A5061703263 @default.
• W3080212115 creator A5074366734 @default.
• W3080212115 creator A5086757144 @default.
• W3080212115 date "2020-08-22" @default.
• W3080212115 modified "2023-09-23" @default.
• W3080212115 title "Reversible cross-tolerance to platelet-activating factor signaling by bacterial toxins" @default.
• W3080212115 cites W1480290224 @default.
• W3080212115 cites W1497550398 @default.
• W3080212115 cites W1589389725 @default.
• W3080212115 cites W1605279589 @default.
• W3080212115 cites W1605478240 @default.
• W3080212115 cites W1893528652 @default.
• W3080212115 cites W1976954262 @default.
• W3080212115 cites W1985260514 @default.
• W3080212115 cites W1998525050 @default.
• W3080212115 cites W2001166416 @default.
• W3080212115 cites W2004773897 @default.
• W3080212115 cites W2023142724 @default.
• W3080212115 cites W2024348167 @default.
• W3080212115 cites W2027161938 @default.
• W3080212115 cites W2030134201 @default.
• W3080212115 cites W2030515395 @default.
• W3080212115 cites W2033340528 @default.
• W3080212115 cites W2035196804 @default.
• W3080212115 cites W2037821855 @default.
• W3080212115 cites W2050274579 @default.
• W3080212115 cites W2058786689 @default.
• W3080212115 cites W2061390335 @default.
• W3080212115 cites W2061514779 @default.
• W3080212115 cites W2062616792 @default.
• W3080212115 cites W2065350927 @default.
• W3080212115 cites W2065429395 @default.
• W3080212115 cites W2079605309 @default.
• W3080212115 cites W2082921049 @default.
• W3080212115 cites W2107472728 @default.
• W3080212115 cites W2112799653 @default.
• W3080212115 cites W2115879450 @default.
• W3080212115 cites W2115893060 @default.
• W3080212115 cites W2122672835 @default.
• W3080212115 cites W2124325717 @default.
• W3080212115 cites W2145343991 @default.
• W3080212115 cites W2146186986 @default.
• W3080212115 cites W2146892797 @default.
• W3080212115 cites W2151923841 @default.
• W3080212115 cites W2157128338 @default.
• W3080212115 cites W2157339124 @default.
• W3080212115 cites W2164372613 @default.
• W3080212115 cites W2164978592 @default.
• W3080212115 cites W2233400185 @default.
• W3080212115 cites W2254084468 @default.
• W3080212115 cites W2312752187 @default.
• W3080212115 cites W2319804978 @default.
• W3080212115 cites W2528948463 @default.
• W3080212115 cites W2888171716 @default.
• W3080212115 cites W2951267517 @default.
• W3080212115 cites W2969378138 @default.
• W3080212115 cites W4229620302 @default.
• W3080212115 doi "https://doi.org/10.1080/09537104.2020.1810652" @default.
• W3080212115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32835559" @default.
• W3080212115 hasPublicationYear "2020" @default.
• W3080212115 type Work @default.
• W3080212115 sameAs 3080212115 @default.
• W3080212115 citedByCount "3" @default.
• W3080212115 countsByYear W30802121152022 @default.
• W3080212115 countsByYear W30802121152023 @default.
• W3080212115 crossrefType "journal-article" @default.
• W3080212115 hasAuthorship W3080212115A5013722163 @default.
• W3080212115 hasAuthorship W3080212115A5015958986 @default.
• W3080212115 hasAuthorship W3080212115A5032644073 @default.
• W3080212115 hasAuthorship W3080212115A5061703263 @default.
• W3080212115 hasAuthorship W3080212115A5074366734 @default.
• W3080212115 hasAuthorship W3080212115A5086757144 @default.
• W3080212115 hasConcept C136449434 @default.
• W3080212115 hasConcept C144464004 @default.
• W3080212115 hasConcept C170493617 @default.
• W3080212115 hasConcept C185592680 @default.
• W3080212115 hasConcept C203014093 @default.
• W3080212115 hasConcept C2776709828 @default.
• W3080212115 hasConcept C2776885963 @default.
• W3080212115 hasConcept C2778754761 @default.
• W3080212115 hasConcept C2779020240 @default.
• W3080212115 hasConcept C2779489039 @default.
• W3080212115 hasConcept C2780955469 @default.
• W3080212115 hasConcept C523546767 @default.
• W3080212115 hasConcept C54355233 @default.
• W3080212115 hasConcept C55493867 @default.
• W3080212115 hasConcept C6977687 @default.
• W3080212115 hasConcept C86803240 @default.
• W3080212115 hasConcept C89423630 @default.
• W3080212115 hasConcept C89560881 @default.
• W3080212115 hasConceptScore W3080212115C136449434 @default.
• W3080212115 hasConceptScore W3080212115C144464004 @default.
• W3080212115 hasConceptScore W3080212115C170493617 @default.

• next