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• W3080212210 endingPage "104178" @default.
• W3080212210 startingPage "104178" @default.
• W3080212210 abstract "Muramic acid (Mur), a sugar amino acid (SAA), is present in the cell walls of bacteria as N-acetyl muramic acid (MurNAc) where together with of N-acetylglucosamine (GlcNAc) and peptide makes main building block of peptidoglycan (PGN). It was challenging to incorporate muramic acid as SAA characteristic for bacteria into the peptides and investigate the antimicrobial activity of these scaffolds. Four building units were used in designing the desired peptide: muramic acid, tetrapeptide Leu-Ser-Lys-Leu, Nε-Lys, and Asn. Positions of three components were changeable while the position of Asn was always C-terminal (in linear peptides). The glycopeptide libraries of linear and cyclic peptides were synthesized using solid-phase peptide synthesis (SPPS). The antimicrobial effect of linear and cyclic glycopeptides, as well as the LSKL sequence used as a control, was investigated on several standard laboratory microbial strains. Liner glycopeptide with sequences Leu-Ser-Lys-Leu-Nε-Lys-Mur-Asn was active on Staphylococcus aureus (Gram-positive bacteria). Prepared compounds did not show activity towards applied tumor and normal human cell lines." @default.
• W3080212210 created "2020-09-01" @default.
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• W3080212210 date "2020-10-01" @default.
• W3080212210 modified "2023-10-06" @default.
• W3080212210 title "Design and synthesis of novel antimicrobial peptide scaffolds" @default.
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• W3080212210 doi "https://doi.org/10.1016/j.bioorg.2020.104178" @default.
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