FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080230584> ?p ?o ?g. }

• W3080230584 abstract "Trichloroethylene (TCE), a common water pollutant linked to Parkinson’s Disease (PD), induces dopaminergic neurodegeneration. L-Theanine (L-Th) was explored as a potential treatment for TCE-induced PD due to its previously elucidated neuroprotective properties. Cell viability, cytotoxicity, and cell density were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay (n=8), lactate dehydrogenase (LDH) assay (n=4), and cell image analysis (n=6), respectively. GT1-7 and SK-N-SH cells served as dopaminergic and neuronal cell models, respectively. In GT1-7 cells, L-Th 600 μM diminished TCE 1000 μM-induced cell death and TCE 1000 μM-induced LDH release by 81% (p<0.001) and 38% (p<0.001), respectively, after 48 h. L-Th also did not significantly impact LDH leakage in healthy GT1-7 cells. In SK-N-SH cells, L-Th 600 μM attenuated TCE 100 μM’s neurodegenerative effects by increasing cellular density and cellular area by 118% (p<0.01) and 170% (p<0.001), respectively, after 24 h. L-Th’s mitigation of TCE’s neurotoxic and neurodegenerative effects in dopaminergic neurons can prevent dopaminergic neurodegeneration: linked to PD onset. L-Th’s ability to preserve healthy GT1-7 cells indicates that L-Th not neurotoxic in vitro. This research marks the identification of the first potential treatment for TCE-induced PD. Future investigations should explore the mechanism of L-Th and TCE’s interactions.Keywords: Trichloroethylene, environmental toxin, L-Theanine, Parkinson’s disease, neurodegeneration." @default.
• W3080230584 created "2020-09-01" @default.
• W3080230584 creator A5079938913 @default.
• W3080230584 date "2020-08-31" @default.
• W3080230584 modified "2023-10-14" @default.
• W3080230584 title "L-Theanine: Neuroprotective against Trichloroethylene-induced Parkinsons disease hallmarks" @default.
• W3080230584 cites W118856678 @default.
• W3080230584 cites W1598408991 @default.
• W3080230584 cites W192122200 @default.
• W3080230584 cites W1967659552 @default.
• W3080230584 cites W1967751090 @default.
• W3080230584 cites W1974965926 @default.
• W3080230584 cites W1979960367 @default.
• W3080230584 cites W1980584581 @default.
• W3080230584 cites W1989447981 @default.
• W3080230584 cites W2001794440 @default.
• W3080230584 cites W2038194332 @default.
• W3080230584 cites W2040257071 @default.
• W3080230584 cites W2044908785 @default.
• W3080230584 cites W2046589157 @default.
• W3080230584 cites W2048089639 @default.
• W3080230584 cites W2050775103 @default.
• W3080230584 cites W2068048197 @default.
• W3080230584 cites W2073449985 @default.
• W3080230584 cites W2107972568 @default.
• W3080230584 cites W2120009307 @default.
• W3080230584 cites W2283673940 @default.
• W3080230584 cites W2521050851 @default.
• W3080230584 cites W2588841770 @default.
• W3080230584 cites W2751849010 @default.
• W3080230584 cites W2761368858 @default.
• W3080230584 cites W2789924103 @default.
• W3080230584 cites W2889197740 @default.
• W3080230584 doi "https://doi.org/10.5897/jtehs2020.0468" @default.
• W3080230584 hasPublicationYear "2020" @default.
• W3080230584 type Work @default.
• W3080230584 sameAs 3080230584 @default.
• W3080230584 citedByCount "1" @default.
• W3080230584 countsByYear W30802305842022 @default.
• W3080230584 crossrefType "journal-article" @default.
• W3080230584 hasAuthorship W3080230584A5079938913 @default.
• W3080230584 hasConcept C107872376 @default.
• W3080230584 hasConcept C109316439 @default.
• W3080230584 hasConcept C126322002 @default.
• W3080230584 hasConcept C137183658 @default.
• W3080230584 hasConcept C1491633281 @default.
• W3080230584 hasConcept C153911025 @default.
• W3080230584 hasConcept C181199279 @default.
• W3080230584 hasConcept C185592680 @default.
• W3080230584 hasConcept C190283241 @default.
• W3080230584 hasConcept C202751555 @default.
• W3080230584 hasConcept C25498285 @default.
• W3080230584 hasConcept C2776925932 @default.
• W3080230584 hasConcept C2777318727 @default.
• W3080230584 hasConcept C2779134260 @default.
• W3080230584 hasConcept C2779404209 @default.
• W3080230584 hasConcept C31573885 @default.
• W3080230584 hasConcept C513476851 @default.
• W3080230584 hasConcept C53227056 @default.
• W3080230584 hasConcept C55493867 @default.
• W3080230584 hasConcept C71924100 @default.
• W3080230584 hasConcept C86803240 @default.
• W3080230584 hasConcept C98274493 @default.
• W3080230584 hasConceptScore W3080230584C107872376 @default.
• W3080230584 hasConceptScore W3080230584C109316439 @default.
• W3080230584 hasConceptScore W3080230584C126322002 @default.
• W3080230584 hasConceptScore W3080230584C137183658 @default.
• W3080230584 hasConceptScore W3080230584C1491633281 @default.
• W3080230584 hasConceptScore W3080230584C153911025 @default.
• W3080230584 hasConceptScore W3080230584C181199279 @default.
• W3080230584 hasConceptScore W3080230584C185592680 @default.
• W3080230584 hasConceptScore W3080230584C190283241 @default.
• W3080230584 hasConceptScore W3080230584C202751555 @default.
• W3080230584 hasConceptScore W3080230584C25498285 @default.
• W3080230584 hasConceptScore W3080230584C2776925932 @default.
• W3080230584 hasConceptScore W3080230584C2777318727 @default.
• W3080230584 hasConceptScore W3080230584C2779134260 @default.
• W3080230584 hasConceptScore W3080230584C2779404209 @default.
• W3080230584 hasConceptScore W3080230584C31573885 @default.
• W3080230584 hasConceptScore W3080230584C513476851 @default.
• W3080230584 hasConceptScore W3080230584C53227056 @default.
• W3080230584 hasConceptScore W3080230584C55493867 @default.
• W3080230584 hasConceptScore W3080230584C71924100 @default.
• W3080230584 hasConceptScore W3080230584C86803240 @default.
• W3080230584 hasConceptScore W3080230584C98274493 @default.
• W3080230584 hasLocation W30802305841 @default.
• W3080230584 hasOpenAccess W3080230584 @default.
• W3080230584 hasPrimaryLocation W30802305841 @default.
• W3080230584 hasRelatedWork W17131581 @default.
• W3080230584 hasRelatedWork W22971494 @default.
• W3080230584 hasRelatedWork W23150650 @default.
• W3080230584 hasRelatedWork W23771414 @default.
• W3080230584 hasRelatedWork W24970923 @default.
• W3080230584 hasRelatedWork W29366428 @default.
• W3080230584 hasRelatedWork W29692181 @default.
• W3080230584 hasRelatedWork W32071582 @default.
• W3080230584 hasRelatedWork W6570301 @default.
• W3080230584 hasRelatedWork W16370069 @default.
• W3080230584 isParatext "false" @default.
• W3080230584 isRetracted "false" @default.

• next