FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080232735> ?p ?o ?g. }

• W3080232735 endingPage "945" @default.
• W3080232735 startingPage "937" @default.
• W3080232735 abstract "The aim of this study was to investigate the role of tumor-associated neutrophils (TANs) in the metastasis of pancreatic ductal adenocarcinoma (PDAC), to explore the regulation of TANs, and to determine the mechanisms governing the metastasis of PDAC. The correlation between neutrophils and the patient’s clinical pathological data was first evaluated. Then, the effects of neutrophils on the invasion of PDAC were analyzed using a combination of conditioned media, direct and indirect coculture of human peripheral blood neutrophils, and PDAC cell lines (Panc-1, MiaPaCa-2 and AsPC-1). The cytokines secreted by neutrophils were detected through ELISA. TAN density was significantly correlated with poor metastasis-free survival (P < .05). Through coculture, it was found that the effect of neutrophils on pancreatic cancer cells was dependent on concentration, and a high concentration of neutrophils showed a lethal effect, while a low concentration of neutrophils primarily promoted the migration ability of cancer cells. The results of the wound-healing assay, the Transwell invasion assay, and laser confocal microscopy confirmed the promoting effect and indicated that the effect of neutrophils toward cancer cells may function indirectly by releasing a series of cytokines. The results of ELISA show that this effect may be achieved through the secretion of a large amount of TNF-α and TGF-β1 by neutrophils. Our study indicated that neutrophils may increase the metastasis of PDAC by releasing a series of cell cytokines, such as TNF-α and TGF-β1." @default.
• W3080232735 created "2020-09-01" @default.
• W3080232735 creator A5006219539 @default.
• W3080232735 creator A5009771110 @default.
• W3080232735 creator A5044329598 @default.
• W3080232735 creator A5045421676 @default.
• W3080232735 creator A5066439685 @default.
• W3080232735 creator A5072756803 @default.
• W3080232735 creator A5086689827 @default.
• W3080232735 date "2020-08-23" @default.
• W3080232735 modified "2023-09-30" @default.
• W3080232735 title "Tumor associated neutrophils promote the metastasis of pancreatic ductal adenocarcinoma" @default.
• W3080232735 cites W1115962392 @default.
• W3080232735 cites W1968812902 @default.
• W3080232735 cites W1969121713 @default.
• W3080232735 cites W1970195787 @default.
• W3080232735 cites W1973985740 @default.
• W3080232735 cites W1980029123 @default.
• W3080232735 cites W1982159979 @default.
• W3080232735 cites W1985130705 @default.
• W3080232735 cites W1985213644 @default.
• W3080232735 cites W2022797070 @default.
• W3080232735 cites W2027260842 @default.
• W3080232735 cites W204597554 @default.
• W3080232735 cites W2076350894 @default.
• W3080232735 cites W2100568503 @default.
• W3080232735 cites W2115732451 @default.
• W3080232735 cites W2146116512 @default.
• W3080232735 cites W2234490399 @default.
• W3080232735 cites W2326575574 @default.
• W3080232735 cites W2439491089 @default.
• W3080232735 cites W2460847595 @default.
• W3080232735 cites W2486425508 @default.
• W3080232735 cites W2489204389 @default.
• W3080232735 cites W2507985549 @default.
• W3080232735 cites W2513439890 @default.
• W3080232735 cites W2525725949 @default.
• W3080232735 cites W2529978013 @default.
• W3080232735 cites W2557659543 @default.
• W3080232735 cites W2592167535 @default.
• W3080232735 cites W2597872842 @default.
• W3080232735 cites W2622600121 @default.
• W3080232735 cites W2762215103 @default.
• W3080232735 cites W2765642791 @default.
• W3080232735 cites W2770010368 @default.
• W3080232735 cites W2775714903 @default.
• W3080232735 cites W2793595097 @default.
• W3080232735 cites W2888000207 @default.
• W3080232735 cites W293548796 @default.
• W3080232735 cites W2987674850 @default.
• W3080232735 doi "https://doi.org/10.1080/15384047.2020.1807250" @default.
• W3080232735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7583704" @default.
• W3080232735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32835587" @default.
• W3080232735 hasPublicationYear "2020" @default.
• W3080232735 type Work @default.
• W3080232735 sameAs 3080232735 @default.
• W3080232735 citedByCount "21" @default.
• W3080232735 countsByYear W30802327352021 @default.
• W3080232735 countsByYear W30802327352022 @default.
• W3080232735 countsByYear W30802327352023 @default.
• W3080232735 crossrefType "journal-article" @default.
• W3080232735 hasAuthorship W3080232735A5006219539 @default.
• W3080232735 hasAuthorship W3080232735A5009771110 @default.
• W3080232735 hasAuthorship W3080232735A5044329598 @default.
• W3080232735 hasAuthorship W3080232735A5045421676 @default.
• W3080232735 hasAuthorship W3080232735A5066439685 @default.
• W3080232735 hasAuthorship W3080232735A5072756803 @default.
• W3080232735 hasAuthorship W3080232735A5086689827 @default.
• W3080232735 hasBestOaLocation W30802327351 @default.
• W3080232735 hasConcept C11957725 @default.
• W3080232735 hasConcept C121608353 @default.
• W3080232735 hasConcept C126322002 @default.
• W3080232735 hasConcept C137738243 @default.
• W3080232735 hasConcept C142724271 @default.
• W3080232735 hasConcept C1491633281 @default.
• W3080232735 hasConcept C17991360 @default.
• W3080232735 hasConcept C185592680 @default.
• W3080232735 hasConcept C203014093 @default.
• W3080232735 hasConcept C2779013556 @default.
• W3080232735 hasConcept C2780210213 @default.
• W3080232735 hasConcept C2781182431 @default.
• W3080232735 hasConcept C49039625 @default.
• W3080232735 hasConcept C502942594 @default.
• W3080232735 hasConcept C55493867 @default.
• W3080232735 hasConcept C71924100 @default.
• W3080232735 hasConcept C86803240 @default.
• W3080232735 hasConcept C96232424 @default.
• W3080232735 hasConceptScore W3080232735C11957725 @default.
• W3080232735 hasConceptScore W3080232735C121608353 @default.
• W3080232735 hasConceptScore W3080232735C126322002 @default.
• W3080232735 hasConceptScore W3080232735C137738243 @default.
• W3080232735 hasConceptScore W3080232735C142724271 @default.
• W3080232735 hasConceptScore W3080232735C1491633281 @default.
• W3080232735 hasConceptScore W3080232735C17991360 @default.
• W3080232735 hasConceptScore W3080232735C185592680 @default.
• W3080232735 hasConceptScore W3080232735C203014093 @default.
• W3080232735 hasConceptScore W3080232735C2779013556 @default.
• W3080232735 hasConceptScore W3080232735C2780210213 @default.

• next