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- W3080236273 abstract "Age-related macular degeneration (AMD) is the leading cause of blindness in the industrialized world. AMD is associated with dysfunction and atrophy of the retinal pigment epithelium (RPE), which provides critical support for photoreceptor survival and function. RPE transplantation is a promising avenue towards a potentially curative treatment for early stage AMD patients, with encouraging reports from animal trials supporting recent progression toward clinical treatments. Mature RPE cells have been reported to be superior, but a detailed investigation of the specific changes in the expression pattern of key RPE genes during maturation is lacking. To understand the effect of maturity on RPE, we investigated transcript levels of 19 key RPE genes using ARPE-19 cell line and human embryonic stem cell-derived RPE cultures. Mature RPE cultures upregulated PEDF, IGF-1, CNTF and BDNF—genes that code for trophic factors known to enhance the survival and function of photoreceptors. Moreover, the mRNA levels of these genes are maximized after 42 days of maturation in culture and lost upon dissociation to single cells. Our findings will help to inform future animal and human RPE transplantation efforts." @default.
- W3080236273 created "2020-09-01" @default.
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- W3080236273 date "2020-08-23" @default.
- W3080236273 modified "2023-10-06" @default.
- W3080236273 title "In Vitro Maturation of Retinal Pigment Epithelium Is Essential for Maintaining High Expression of Key Functional Genes" @default.
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- W3080236273 doi "https://doi.org/10.3390/ijms21176066" @default.
- W3080236273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7503905" @default.
- W3080236273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32842471" @default.
- W3080236273 hasPublicationYear "2020" @default.
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