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- W3080252108 abstract "Acute pancreatitis (AP) refers to inflammation in the pancreas, which may lead to death in severe cases. Coenzyme Q10 (Q10), generally known to generate energy, plays an important role as an anti-oxidant and anti-inflammatory effector. Here, we showed the effect of Q10 on inflammatory response in murine AP model. For this study, we induced AP by injection of cerulein intraperitoneally or pancreatic duct ligation (PDL) in mice. The level of cytokines and digestive enzymes were measured in pancreas, and blood. All pancreatic tissues were excised for investigation such as histological changes, infiltration of immune cells. Administration of Q10 attenuated the severity of AP and its associated pulmonary complication as shown by reduction of acinar cell death, parenchymal edema, inflammatory cell infiltration and alveolar thickening in both cerulein-induced AP and PDL-induced AP. Moreover, reduction of the cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α were observed in pancreas and pancreatic acinar cells by Q10. Furthermore, Q10 reduced the infiltration of immune cells such as monocytes and neutrophils and augmentation of chemokines such as CC chemokine-2 (CCL2) and C-X-C chemokine-2 (CXCL2) in pancreas of AP mice. In addition, Q10 deactivates the phosphorylation of extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase (JNK) in pancreas. In conclusion, these observations suggest that Q10 could attenuate the pancreatic damage and its associated pulmonary complications via inhibition of inflammatory cytokines and inflammatory cell infiltration and that the deactivation of ERK and JNK by Q10 might contribute to the attenuation of AP." @default.
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- W3080252108 date "2020-11-01" @default.
- W3080252108 modified "2023-09-30" @default.
- W3080252108 title "Protective effects of Coenzyme Q10 against acute pancreatitis" @default.
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- W3080252108 cites W1973654637 @default.
- W3080252108 cites W1982401458 @default.
- W3080252108 cites W1992827477 @default.
- W3080252108 cites W1997634690 @default.
- W3080252108 cites W1999688501 @default.
- W3080252108 cites W2000755489 @default.
- W3080252108 cites W2002288692 @default.
- W3080252108 cites W2016895203 @default.
- W3080252108 cites W2022580158 @default.
- W3080252108 cites W2044045006 @default.
- W3080252108 cites W2046080098 @default.
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- W3080252108 cites W2057807822 @default.
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- W3080252108 doi "https://doi.org/10.1016/j.intimp.2020.106900" @default.
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