Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080252379> ?p ?o ?g. }
- W3080252379 endingPage "102262" @default.
- W3080252379 startingPage "102262" @default.
- W3080252379 abstract "Clostridium perfringens type A-induced gas gangrene is characterized by severe myonecrosis, and α-toxin has been revealed to be a major virulence factor involved in the pathogenesis. However, the detailed mechanism is unclear. Here, we show that CD31+ endothelial cell counts decrease in muscles infected with C. perfringens in an α-toxin-dependent manner. In vitro experiments revealed that α-toxin preferentially and rapidly induces the death of human umbilical vein endothelial cells (HUVECs) compared with C2C12 murine muscle cells. The toxin induces apoptosis of HUVECs by increasing ceramide. Furthermore, the specificity might be dependent on differences in the sensitivity to ceramide between these cell lines. Together, our results suggest that α-toxin-induced endothelial cell death promotes severe myonecrosis and is involved in the pathogenesis of C. perfringens." @default.
- W3080252379 created "2020-09-01" @default.
- W3080252379 creator A5061164576 @default.
- W3080252379 creator A5080530083 @default.
- W3080252379 creator A5088326467 @default.
- W3080252379 creator A5091502063 @default.
- W3080252379 date "2020-10-01" @default.
- W3080252379 modified "2023-10-16" @default.
- W3080252379 title "Clostridium perfringens α-toxin specifically induces endothelial cell death by promoting ceramide-mediated apoptosis" @default.
- W3080252379 cites W1516091124 @default.
- W3080252379 cites W1526960897 @default.
- W3080252379 cites W1576534665 @default.
- W3080252379 cites W1915983197 @default.
- W3080252379 cites W1963501822 @default.
- W3080252379 cites W1965186407 @default.
- W3080252379 cites W1966154210 @default.
- W3080252379 cites W1976821526 @default.
- W3080252379 cites W1977892595 @default.
- W3080252379 cites W1984561439 @default.
- W3080252379 cites W1985139418 @default.
- W3080252379 cites W1993093223 @default.
- W3080252379 cites W2029626396 @default.
- W3080252379 cites W2029882486 @default.
- W3080252379 cites W2030138800 @default.
- W3080252379 cites W2051981166 @default.
- W3080252379 cites W2084986127 @default.
- W3080252379 cites W2094747654 @default.
- W3080252379 cites W2101977333 @default.
- W3080252379 cites W2111013063 @default.
- W3080252379 cites W2112915882 @default.
- W3080252379 cites W2121960517 @default.
- W3080252379 cites W2129278645 @default.
- W3080252379 cites W2130860011 @default.
- W3080252379 cites W2138941955 @default.
- W3080252379 cites W2141998772 @default.
- W3080252379 cites W2146755217 @default.
- W3080252379 cites W2157804398 @default.
- W3080252379 cites W2167103844 @default.
- W3080252379 cites W2170673486 @default.
- W3080252379 cites W2438570867 @default.
- W3080252379 cites W2526152819 @default.
- W3080252379 cites W2529757271 @default.
- W3080252379 cites W2793030599 @default.
- W3080252379 cites W2913793940 @default.
- W3080252379 cites W2951166728 @default.
- W3080252379 cites W2970208991 @default.
- W3080252379 doi "https://doi.org/10.1016/j.anaerobe.2020.102262" @default.
- W3080252379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32828915" @default.
- W3080252379 hasPublicationYear "2020" @default.
- W3080252379 type Work @default.
- W3080252379 sameAs 3080252379 @default.
- W3080252379 citedByCount "7" @default.
- W3080252379 countsByYear W30802523792021 @default.
- W3080252379 countsByYear W30802523792022 @default.
- W3080252379 countsByYear W30802523792023 @default.
- W3080252379 crossrefType "journal-article" @default.
- W3080252379 hasAuthorship W3080252379A5061164576 @default.
- W3080252379 hasAuthorship W3080252379A5080530083 @default.
- W3080252379 hasAuthorship W3080252379A5088326467 @default.
- W3080252379 hasAuthorship W3080252379A5091502063 @default.
- W3080252379 hasConcept C104317684 @default.
- W3080252379 hasConcept C123012128 @default.
- W3080252379 hasConcept C190283241 @default.
- W3080252379 hasConcept C202751555 @default.
- W3080252379 hasConcept C203014093 @default.
- W3080252379 hasConcept C2777367657 @default.
- W3080252379 hasConcept C2777411675 @default.
- W3080252379 hasConcept C2777851122 @default.
- W3080252379 hasConcept C2778939058 @default.
- W3080252379 hasConcept C2779116991 @default.
- W3080252379 hasConcept C2780394083 @default.
- W3080252379 hasConcept C2780942790 @default.
- W3080252379 hasConcept C2781090273 @default.
- W3080252379 hasConcept C31573885 @default.
- W3080252379 hasConcept C502942594 @default.
- W3080252379 hasConcept C523546767 @default.
- W3080252379 hasConcept C54355233 @default.
- W3080252379 hasConcept C55493867 @default.
- W3080252379 hasConcept C60987743 @default.
- W3080252379 hasConcept C86803240 @default.
- W3080252379 hasConcept C89423630 @default.
- W3080252379 hasConcept C95444343 @default.
- W3080252379 hasConceptScore W3080252379C104317684 @default.
- W3080252379 hasConceptScore W3080252379C123012128 @default.
- W3080252379 hasConceptScore W3080252379C190283241 @default.
- W3080252379 hasConceptScore W3080252379C202751555 @default.
- W3080252379 hasConceptScore W3080252379C203014093 @default.
- W3080252379 hasConceptScore W3080252379C2777367657 @default.
- W3080252379 hasConceptScore W3080252379C2777411675 @default.
- W3080252379 hasConceptScore W3080252379C2777851122 @default.
- W3080252379 hasConceptScore W3080252379C2778939058 @default.
- W3080252379 hasConceptScore W3080252379C2779116991 @default.
- W3080252379 hasConceptScore W3080252379C2780394083 @default.
- W3080252379 hasConceptScore W3080252379C2780942790 @default.
- W3080252379 hasConceptScore W3080252379C2781090273 @default.
- W3080252379 hasConceptScore W3080252379C31573885 @default.
- W3080252379 hasConceptScore W3080252379C502942594 @default.
- W3080252379 hasConceptScore W3080252379C523546767 @default.