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• W3080269169 endingPage "104845" @default.
• W3080269169 startingPage "104845" @default.
• W3080269169 abstract "Abstract Social instability stress (SS; daily 1 h isolation and change of cage partner from postnatal day (P) 30–45) in adolescence produces elevations in corticosterone during the procedure in male and female rats, but no lasting changes in hypothalamic-pituitary-adrenal (HPA) responses to psychological stressors, although deficits in social and cognitive function are evident in adulthood. Here we investigated the effects of SS in corticosterone response to an immune challenge (lipopolysaccharide, LPS, 0.1 mg/kg), on gene expression in the hippocampus, and on gut microbiota, when tested soon- (P46) or long- (P70) after SS. The temporal pattern of corticosterone release after LPS differed between SS and control rats irrespective of the time since SS exposure in females, whereas in males, SS did not alter corticosterone release after LPS. Expression of genes in the hippocampus relevant to immune and HPA function differed between saline-treated SS and control rats depending on sex and time tested, but with lasting consequences of SS in both sexes. LPS-treatment altered hippocampal gene expression, with bigger effects of LPS evident in control than in SS female rats, and the opposite in male rats. Further, effects sometimes depended on the age at time of LPS treatment. SS and control rats differed in both fecal and colon microbiome composition in all but P46 males, and stress history, sex, and age influenced the effects of an immune challenge on the gut microbiome. In sum, adolescent stress history has consequences for immune function into adulthood that may involve effects on the gut microbiome." @default.
• W3080269169 created "2020-09-01" @default.
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• W3080269169 date "2020-11-01" @default.
• W3080269169 modified "2023-09-24" @default.
• W3080269169 title "Adolescent social instability stress leads to immediate and lasting sex-specific changes in the neuroendocrine-immune-gut axis in rats" @default.
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• W3080269169 doi "https://doi.org/10.1016/j.yhbeh.2020.104845" @default.
• W3080269169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32846188" @default.
• W3080269169 hasPublicationYear "2020" @default.
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