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- W3080272431 abstract "Adoptive cellular therapy involves the ex vivo expansion of immune cells, conventionally T cells, before reinfusion back to the patient. Variations in adoptive cellular therapy include transduction of a patient’s T cells with either a transgenic T cell receptor or chimeric antigen receptor (CAR) to recognize a defined tumor antigen. Given that adenosine is a major axis of immunosuppression of T cells, particularly in hypoxic tumor microenvironments, therapeutics targeting this pathway are currently being assessed for their potential to enhance adoptive T cell therapies. The use of gene-editing technology, commonly used in tandem with CAR and transgenic T cell receptor (TCR) based adoptive cellular therapy, offers further opportunities to specifically modulate responses to adenosine. This review will discuss recent advances in targeting the adenosine pathway for enhancing the effectiveness of adoptive cellular therapy in the treatment of solid cancers." @default.
- W3080272431 created "2020-09-01" @default.
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- W3080272431 date "2020-08-01" @default.
- W3080272431 modified "2023-09-23" @default.
- W3080272431 title "Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer" @default.
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- W3080272431 doi "https://doi.org/10.1016/j.coph.2020.07.002" @default.
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