FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080277513> ?p ?o ?g. }

• W3080277513 endingPage "57" @default.
• W3080277513 startingPage "44" @default.
• W3080277513 abstract "Toll-like receptor (TLR) 4 signalling is critical for innate immunoinflammatory response and widely triggers the development of various types of clinical diseases. MicroRNA-7 (miR-7) is well documented to play an important regulatory role in various biological events. However, the exact role of miR-7 in TLR4 signalling pathway remains to be fully elucidated. In the present study, we found that miR-7 expression in TLR4 signalling-activated bone marrow-derived macrophages (BMDMs) stimulated by LPS was dramatically increased. Importantly, miR-7 deficiency significantly enhanced the production of related inflammatory cytokines including IL-1β, IL-6 and IL-12, as well as TNF-α, on LPS-activated BMDMs, accompanied by elevated transduction of TLR4 signalling including Myd88-dependent and Myd88-independent pathways, whereas miR-7 overexpression significantly decreased the transduction of TLR4 signalling and the production of related inflammatory cytokines. Mechanistically, we identified family with sequence similarity 177, member A (FAM177A) as a novel target molecule of miR-7. Furthermore, down-regulation of FAM177A using RNAi could impair the transduction of TLR4 signalling. Finally, down-regulation of FAM177A also reversed the effect of miR-7 deficiency on TLR4 signalling transduction and production of related inflammatory cytokines on BMDMs. Therefore, we provide the new evidence that miR-7 acts as a novel negative fine-tuner in regulating TLR4 signalling pathways by targeting FAM177A, which might throw light on the basal understanding on the regulatory mechanism of TLR4 signalling and benefit the development of therapeutic strategies against related clinical diseases." @default.
• W3080277513 created "2020-09-01" @default.
• W3080277513 creator A5002456827 @default.
• W3080277513 creator A5006748751 @default.
• W3080277513 creator A5027195409 @default.
• W3080277513 creator A5045409917 @default.
• W3080277513 creator A5056248574 @default.
• W3080277513 creator A5061100053 @default.
• W3080277513 creator A5083915636 @default.
• W3080277513 creator A5089104357 @default.
• W3080277513 date "2020-10-19" @default.
• W3080277513 modified "2023-10-16" @default.
• W3080277513 title "MicroRNA‐7 negatively regulates Toll‐like receptor 4 signaling pathway through FAM177A" @default.
• W3080277513 cites W1483162601 @default.
• W3080277513 cites W1744771032 @default.
• W3080277513 cites W1894780382 @default.
• W3080277513 cites W1988327539 @default.
• W3080277513 cites W2015263036 @default.
• W3080277513 cites W2020932061 @default.
• W3080277513 cites W2027996995 @default.
• W3080277513 cites W2073382731 @default.
• W3080277513 cites W2088230667 @default.
• W3080277513 cites W2137777508 @default.
• W3080277513 cites W2170068488 @default.
• W3080277513 cites W2208497492 @default.
• W3080277513 cites W2342859699 @default.
• W3080277513 cites W2344808711 @default.
• W3080277513 cites W2528606382 @default.
• W3080277513 cites W2538771555 @default.
• W3080277513 cites W2561449450 @default.
• W3080277513 cites W2581613894 @default.
• W3080277513 cites W2606615337 @default.
• W3080277513 cites W2738155789 @default.
• W3080277513 cites W2765345450 @default.
• W3080277513 cites W2766359205 @default.
• W3080277513 cites W2796104433 @default.
• W3080277513 cites W2800170182 @default.
• W3080277513 cites W2800750353 @default.
• W3080277513 cites W2808309841 @default.
• W3080277513 cites W2890683530 @default.
• W3080277513 cites W2891202732 @default.
• W3080277513 cites W2906420888 @default.
• W3080277513 cites W2913512944 @default.
• W3080277513 cites W2920655227 @default.
• W3080277513 cites W2922251158 @default.
• W3080277513 cites W2936128431 @default.
• W3080277513 cites W2944728970 @default.
• W3080277513 cites W2944997219 @default.
• W3080277513 cites W2945735701 @default.
• W3080277513 cites W2950750675 @default.
• W3080277513 cites W2952751640 @default.
• W3080277513 cites W3005006265 @default.
• W3080277513 cites W4234276020 @default.
• W3080277513 cites W2794403750 @default.
• W3080277513 doi "https://doi.org/10.1111/imm.13252" @default.
• W3080277513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7730018" @default.
• W3080277513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32852789" @default.
• W3080277513 hasPublicationYear "2020" @default.
• W3080277513 type Work @default.
• W3080277513 sameAs 3080277513 @default.
• W3080277513 citedByCount "10" @default.
• W3080277513 countsByYear W30802775132021 @default.
• W3080277513 countsByYear W30802775132022 @default.
• W3080277513 countsByYear W30802775132023 @default.
• W3080277513 crossrefType "journal-article" @default.
• W3080277513 hasAuthorship W3080277513A5002456827 @default.
• W3080277513 hasAuthorship W3080277513A5006748751 @default.
• W3080277513 hasAuthorship W3080277513A5027195409 @default.
• W3080277513 hasAuthorship W3080277513A5045409917 @default.
• W3080277513 hasAuthorship W3080277513A5056248574 @default.
• W3080277513 hasAuthorship W3080277513A5061100053 @default.
• W3080277513 hasAuthorship W3080277513A5083915636 @default.
• W3080277513 hasAuthorship W3080277513A5089104357 @default.
• W3080277513 hasBestOaLocation W30802775131 @default.
• W3080277513 hasConcept C104317684 @default.
• W3080277513 hasConcept C126042315 @default.
• W3080277513 hasConcept C136449434 @default.
• W3080277513 hasConcept C145059251 @default.
• W3080277513 hasConcept C162354598 @default.
• W3080277513 hasConcept C170493617 @default.
• W3080277513 hasConcept C203014093 @default.
• W3080277513 hasConcept C2776070231 @default.
• W3080277513 hasConcept C2776709828 @default.
• W3080277513 hasConcept C2776914184 @default.
• W3080277513 hasConcept C2778923194 @default.
• W3080277513 hasConcept C39743133 @default.
• W3080277513 hasConcept C54355233 @default.
• W3080277513 hasConcept C62478195 @default.
• W3080277513 hasConcept C86803240 @default.
• W3080277513 hasConcept C95444343 @default.
• W3080277513 hasConceptScore W3080277513C104317684 @default.
• W3080277513 hasConceptScore W3080277513C126042315 @default.
• W3080277513 hasConceptScore W3080277513C136449434 @default.
• W3080277513 hasConceptScore W3080277513C145059251 @default.
• W3080277513 hasConceptScore W3080277513C162354598 @default.
• W3080277513 hasConceptScore W3080277513C170493617 @default.
• W3080277513 hasConceptScore W3080277513C203014093 @default.
• W3080277513 hasConceptScore W3080277513C2776070231 @default.

• next