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- W3080300681 abstract "Abstract Skeletal muscle is paradigmatic of a regenerative tissue that repairs itself via the activation of a resident stem cell 1 . Termed the satellite cell, these normally quiescent cells are induced to proliferate by ill-defined wound-derived signals 2 . Identifying the source and nature of these pro-regenerative cues has been hampered by an inability to visualise the complex cellular interactions that occur within the wound environment. We therefore developed a zebrafish muscle injury model to systematically capture satellite cell interactions within the injury site, in real time, throughout the repair process. This analysis identified that a specific subset of macrophages ‘dwells’ within the injury, establishing a transient but obligate stem cell niche required for stem cell proliferation. Single cell profiling identified specific signals secreted from dwelling macrophages that include the cytokine, Nicotinamide phosphoribosyltransferase (NAMPT/Visfatin/PBEF). Here we show that NAMPT secretion from the macrophage niche is required for muscle regeneration, acting through the C-C motif chemokine receptor type 5 (CCR5) expressed on muscle stem cells. This analysis reveals that along with their well-described ability to modulate the pro-inflammatory and anti-inflammatory phases of wound repair, specific macrophage populations also provide a transient stem cell-activating niche, directly supplying pro-proliferative cues that govern the timing and rate of muscle stem cell-mediated repair processes." @default.
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- W3080300681 date "2020-08-24" @default.
- W3080300681 modified "2023-09-23" @default.
- W3080300681 title "Macrophages provide a transient muscle stem cell niche via NAMPT secretion" @default.
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- W3080300681 doi "https://doi.org/10.1101/2020.08.24.262428" @default.
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