Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080338110> ?p ?o ?g. }
- W3080338110 endingPage "141" @default.
- W3080338110 startingPage "132" @default.
- W3080338110 abstract "Hepatocellular carcinoma (HCC) is a common neoplastic transformation of the hepatocytes, which has high morbidity and mortality worldwide, particularly in Eastern Asia. HCC is also developed as a consequence of chronic liver cirrhosis, and both diseases are difficult to diagnosis and differentiate. Accurate noninvasive biomarkers for HCC and cirrhosis are urgently needed. In the search for novel candidates, small extracellular vesicles (sEVs) were isolated from the serum of liver cancer patients, liver cirrhosis patients, healthy control subjects, as well as the culture media of hepatocellular carcinoma cells (HepG2) and normal hepatocyte cells (Lo2). Isolated sEVs were confirmed by size distribution analysis, morphological analysis, and surface biomarker tests. Mass spectrometry based label-free quantification revealed 61 and 63 differentially expressed proteins in the serum sEVs of liver cirrhosis patients and liver cancer patients (p < 0.05), respectively. The proteomics data of cell-derived sEVs were combined for the selection of valuable candidates. Promising proteins were further verified by immunoassay, including thrombospondin-1 (THBS1), fibulin-1(FBLN1), and fibrinogen gamma chain (FGG), which could differentiate healthy control from liver cancer or liver cirrhosis. Our findings verified the hypothesis that cancer-related proteomics signatures are present in the sEVs of patient’s serum and might be monitored for the evaluation of liver cancer and liver cirrhosis." @default.
- W3080338110 created "2020-09-01" @default.
- W3080338110 creator A5016053889 @default.
- W3080338110 creator A5017836963 @default.
- W3080338110 creator A5027468941 @default.
- W3080338110 creator A5028536688 @default.
- W3080338110 creator A5029748739 @default.
- W3080338110 creator A5031199297 @default.
- W3080338110 creator A5041291183 @default.
- W3080338110 creator A5053882773 @default.
- W3080338110 creator A5068494180 @default.
- W3080338110 date "2020-10-01" @default.
- W3080338110 modified "2023-10-17" @default.
- W3080338110 title "Discovery of small extracellular vesicle proteins from human serum for liver cirrhosis and liver cancer" @default.
- W3080338110 cites W1975231763 @default.
- W3080338110 cites W1990329052 @default.
- W3080338110 cites W1996219280 @default.
- W3080338110 cites W2037199116 @default.
- W3080338110 cites W2046196682 @default.
- W3080338110 cites W2062410076 @default.
- W3080338110 cites W2072595668 @default.
- W3080338110 cites W2092952885 @default.
- W3080338110 cites W2098259366 @default.
- W3080338110 cites W2121354606 @default.
- W3080338110 cites W2152032401 @default.
- W3080338110 cites W2155980822 @default.
- W3080338110 cites W2159114297 @default.
- W3080338110 cites W2340629756 @default.
- W3080338110 cites W2490769112 @default.
- W3080338110 cites W2512730605 @default.
- W3080338110 cites W2528206229 @default.
- W3080338110 cites W2564217421 @default.
- W3080338110 cites W2588207394 @default.
- W3080338110 cites W2589694509 @default.
- W3080338110 cites W2598108680 @default.
- W3080338110 cites W2598910330 @default.
- W3080338110 cites W2619076775 @default.
- W3080338110 cites W2624860380 @default.
- W3080338110 cites W2753111692 @default.
- W3080338110 cites W2762316662 @default.
- W3080338110 cites W2765280408 @default.
- W3080338110 cites W2779683706 @default.
- W3080338110 cites W2786111433 @default.
- W3080338110 cites W2788119193 @default.
- W3080338110 cites W2790169109 @default.
- W3080338110 cites W2799723593 @default.
- W3080338110 cites W2803033440 @default.
- W3080338110 cites W2808120958 @default.
- W3080338110 cites W2886898030 @default.
- W3080338110 cites W2889646458 @default.
- W3080338110 cites W2892761766 @default.
- W3080338110 cites W2898446097 @default.
- W3080338110 cites W2900340831 @default.
- W3080338110 cites W2945221882 @default.
- W3080338110 doi "https://doi.org/10.1016/j.biochi.2020.08.013" @default.
- W3080338110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32835735" @default.
- W3080338110 hasPublicationYear "2020" @default.
- W3080338110 type Work @default.
- W3080338110 sameAs 3080338110 @default.
- W3080338110 citedByCount "15" @default.
- W3080338110 countsByYear W30803381102021 @default.
- W3080338110 countsByYear W30803381102022 @default.
- W3080338110 countsByYear W30803381102023 @default.
- W3080338110 crossrefType "journal-article" @default.
- W3080338110 hasAuthorship W3080338110A5016053889 @default.
- W3080338110 hasAuthorship W3080338110A5017836963 @default.
- W3080338110 hasAuthorship W3080338110A5027468941 @default.
- W3080338110 hasAuthorship W3080338110A5028536688 @default.
- W3080338110 hasAuthorship W3080338110A5029748739 @default.
- W3080338110 hasAuthorship W3080338110A5031199297 @default.
- W3080338110 hasAuthorship W3080338110A5041291183 @default.
- W3080338110 hasAuthorship W3080338110A5053882773 @default.
- W3080338110 hasAuthorship W3080338110A5068494180 @default.
- W3080338110 hasConcept C121608353 @default.
- W3080338110 hasConcept C126322002 @default.
- W3080338110 hasConcept C142724271 @default.
- W3080338110 hasConcept C2776231280 @default.
- W3080338110 hasConcept C2777214474 @default.
- W3080338110 hasConcept C2778019345 @default.
- W3080338110 hasConcept C2781197716 @default.
- W3080338110 hasConcept C502942594 @default.
- W3080338110 hasConcept C55493867 @default.
- W3080338110 hasConcept C71924100 @default.
- W3080338110 hasConcept C86803240 @default.
- W3080338110 hasConcept C90924648 @default.
- W3080338110 hasConceptScore W3080338110C121608353 @default.
- W3080338110 hasConceptScore W3080338110C126322002 @default.
- W3080338110 hasConceptScore W3080338110C142724271 @default.
- W3080338110 hasConceptScore W3080338110C2776231280 @default.
- W3080338110 hasConceptScore W3080338110C2777214474 @default.
- W3080338110 hasConceptScore W3080338110C2778019345 @default.
- W3080338110 hasConceptScore W3080338110C2781197716 @default.
- W3080338110 hasConceptScore W3080338110C502942594 @default.
- W3080338110 hasConceptScore W3080338110C55493867 @default.
- W3080338110 hasConceptScore W3080338110C71924100 @default.
- W3080338110 hasConceptScore W3080338110C86803240 @default.
- W3080338110 hasConceptScore W3080338110C90924648 @default.
- W3080338110 hasFunder F4320321001 @default.