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• W3080351630 endingPage "205873842094619" @default.
• W3080351630 startingPage "205873842094619" @default.
• W3080351630 abstract "The glucocorticoid receptor (GR) is one of the most widely studied ligand-dependent nuclear receptors. The combination of transcriptional regulatory factors required for the expression of individual genes targeted by GR varies across cell types; however, the mechanisms underlying this cell type-specific regulation of gene expression are not yet clear.Here, we investigated genes regulated by GR in two different cell lines, A549 and ARPE-19, and examined how gene expression varied according to the effect of pioneer factors using RNA-seq and RT-qPCR.Our RNA-seq results identified 19 and 63 genes regulated by GR that are ARPE-19-specific and A549-specific, respectively, suggesting that GR induces the expression of different sets of genes in a cell type-specific manner. RT-qPCR confirmed that the epithelial sodium channel (ENACα) gene is an ARPE-19 cell-specific GR target gene, whereas the FK506 binding protein 5 (FKBP5) gene was A549 cell-specific. There was a significant decrease in ENACα expression in FOXA1-deficient ARPE-19 cells, suggesting that FOXA1 might function as a pioneer factor enabling the selective expression of ENACα in ARPE-19 cells but not in A549 cells.These findings indicate that ENACα expression in ARPE-19 cells is regulated by FOXA1 and provide insights into the molecular mechanisms of cell type-specific expression of GR-regulated genes." @default.
• W3080351630 created "2020-09-01" @default.
• W3080351630 creator A5044437556 @default.
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• W3080351630 date "2020-01-01" @default.
• W3080351630 modified "2023-09-24" @default.
• W3080351630 title "Cell-specific expression of ENACα gene by FOXA1 in the glucocorticoid receptor pathway" @default.
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• W3080351630 doi "https://doi.org/10.1177/2058738420946192" @default.
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