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• W3080357088 abstract "Abstract Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of AAA and accelerates macrophage-driven proteolytic damage of the aortic wall. ALI-induced HMGB1 leaks and is captured by arterial macrophages thereby altering their mitochondrial metabolism through RIPK3. RIPK3 promotes mitochondrial fission leading to elevated oxidative stress via DRP1. This triggers MMP12 to lyse arterial matrix, thereby stimulating AAA. Administration of recombinant HMGB1 to WT, but not Ripk3 −/− mice, recapitulates ALI-induced proteolytic collapse of arterial architecture. Deletion of RIPK3 in myeloid cells, DRP1 or MMP12 suppression in ALI-inflicted mice repress arterial stress and brake MMP12 release by transmural macrophages thereby maintaining a strengthened arterial framework refractory to AAA. Our results establish an inter-organ circuitry that alerts arterial macrophages to regulate vascular remodeling." @default.
• W3080357088 created "2020-09-01" @default.
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• W3080357088 date "2020-08-27" @default.
• W3080357088 modified "2023-09-30" @default.
• W3080357088 title "Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages" @default.
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• W3080357088 doi "https://doi.org/10.1038/s41467-020-18088-2" @default.
• W3080357088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7453029" @default.
• W3080357088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32855420" @default.
• W3080357088 hasPublicationYear "2020" @default.
• W3080357088 type Work @default.

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