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• W3080363208 abstract "ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory disease. Characterizing PDAC by mRNA profiling remains particularly challenging. Previously identified bulk expression subtypes were influenced by contaminating stroma and have not yet informed clinical management, whereas single cell RNA-seq (scRNA-seq) of fresh tumors under-represented key cell types. Here, we developed a robust single-nucleus RNA-seq (snRNA-seq) technique for frozen archival PDAC specimens and used it to study both untreated tumors and those that received neoadjuvant chemotherapy and radiotherapy (CRT). Gene expression programs learned across untreated malignant cell and fibroblast profiles uncovered a clinically relevant molecular taxonomy with improved prognostic stratification compared to prior classifications. Moreover, in the increasingly-adopted neoadjuvant treatment context, there was a depletion of classical-like phenotypes in malignant cells in favor of basal-like phenotypes associated with TNF-NFkB and interferon signaling as well as the presence of novel acinar and neuroendocrine classical-like states, which may be more resilient to cytotoxic treatment. Spatially-resolved transcriptomics revealed an association between malignant cells expressing these basal-like programs and higher immune infiltration with increased lymphocytic content, whereas those exhibiting classical-like programs were linked to sparser macrophage-predominant microniches, perhaps pointing to susceptibility to distinct therapeutic strategies. Our refined molecular taxonomy and spatial resolution can help advance precision oncology in PDAC through informative stratification in clinical trials and insights into differential therapeutic targeting leveraging the immune system." @default.
• W3080363208 created "2020-09-01" @default.
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• W3080363208 date "2020-08-25" @default.
• W3080363208 modified "2023-10-18" @default.
• W3080363208 title "Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment" @default.
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• W3080363208 cites W1497915798 @default.
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• W3080363208 cites W1529251418 @default.
• W3080363208 cites W1611944043 @default.
• W3080363208 cites W1951724000 @default.
• W3080363208 cites W1954497589 @default.
• W3080363208 cites W1968812902 @default.
• W3080363208 cites W1970008083 @default.
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• W3080363208 cites W1982171810 @default.
• W3080363208 cites W1982781304 @default.
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• W3080363208 cites W1984560157 @default.
• W3080363208 cites W1987385630 @default.
• W3080363208 cites W1989556137 @default.
• W3080363208 cites W1992567931 @default.
• W3080363208 cites W1992733293 @default.
• W3080363208 cites W1994826332 @default.
• W3080363208 cites W1999574084 @default.
• W3080363208 cites W2006987558 @default.
• W3080363208 cites W2010457001 @default.
• W3080363208 cites W2010769173 @default.
• W3080363208 cites W2023571913 @default.
• W3080363208 cites W2024863001 @default.
• W3080363208 cites W2028915020 @default.
• W3080363208 cites W2030017878 @default.
• W3080363208 cites W2032780125 @default.
• W3080363208 cites W2034855296 @default.
• W3080363208 cites W2038218697 @default.
• W3080363208 cites W2043565262 @default.
• W3080363208 cites W2047902191 @default.
• W3080363208 cites W2054995801 @default.
• W3080363208 cites W2061538006 @default.
• W3080363208 cites W2077203252 @default.
• W3080363208 cites W2078490888 @default.
• W3080363208 cites W2081796577 @default.
• W3080363208 cites W2086834665 @default.
• W3080363208 cites W2088110734 @default.
• W3080363208 cites W2096065464 @default.
• W3080363208 cites W2107551122 @default.
• W3080363208 cites W2120426523 @default.
• W3080363208 cites W2123093878 @default.
• W3080363208 cites W2127733313 @default.
• W3080363208 cites W2130410032 @default.
• W3080363208 cites W2132163449 @default.

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