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- W3080398302 abstract "Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically programmed to integrate iron catalysis, drug delivery, and tracking exploiting the characteristics of the tumor microenvironment (TME), improves immunotherapy and activation of ferroptosis. The IONVs trigger danger signals and use molecular disassembly and reversible covalent bonds for targeted antigen delivery and improved immunostimulatory capacity and catalytic iron for targeting tumor cell ferroptosis. IONV- and antibody-mediated TME modulation interfaced with imaging was important toward achieving complete eradication of aggressive and established tumors, eliciting long-lived protective antitumor immunity with no toxicities. This work establishes the feasibility of using nanoparticle iron catalytic activity as a versatile and effective feature for enhancing immunotherapy." @default.
- W3080398302 created "2020-09-01" @default.
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- W3080398302 date "2020-09-01" @default.
- W3080398302 modified "2023-10-16" @default.
- W3080398302 title "Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis" @default.
- W3080398302 cites W1748067466 @default.
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- W3080398302 cites W1913780655 @default.
- W3080398302 cites W1942897646 @default.
- W3080398302 cites W1967434989 @default.
- W3080398302 cites W1973193910 @default.
- W3080398302 cites W1982125899 @default.
- W3080398302 cites W2042699075 @default.
- W3080398302 cites W2046879878 @default.
- W3080398302 cites W2047350084 @default.
- W3080398302 cites W2052543023 @default.
- W3080398302 cites W2052926310 @default.
- W3080398302 cites W2060672294 @default.
- W3080398302 cites W2065934830 @default.
- W3080398302 cites W2088317237 @default.
- W3080398302 cites W2092747941 @default.
- W3080398302 cites W2093061584 @default.
- W3080398302 cites W2097177856 @default.
- W3080398302 cites W2115269770 @default.
- W3080398302 cites W2116158418 @default.
- W3080398302 cites W2138250841 @default.
- W3080398302 cites W2141172772 @default.
- W3080398302 cites W2144735647 @default.
- W3080398302 cites W2144949343 @default.
- W3080398302 cites W2152472950 @default.
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- W3080398302 cites W2161684993 @default.
- W3080398302 cites W2163045334 @default.
- W3080398302 cites W2189205651 @default.
- W3080398302 cites W2189381691 @default.
- W3080398302 cites W2219584703 @default.
- W3080398302 cites W2264178661 @default.
- W3080398302 cites W2307487014 @default.
- W3080398302 cites W2314057593 @default.
- W3080398302 cites W2320574135 @default.
- W3080398302 cites W2344850880 @default.
- W3080398302 cites W2418379976 @default.
- W3080398302 cites W2427645657 @default.
- W3080398302 cites W2473218705 @default.
- W3080398302 cites W2527636586 @default.
- W3080398302 cites W2549452223 @default.
- W3080398302 cites W2564809671 @default.
- W3080398302 cites W2596760231 @default.
- W3080398302 cites W2605166062 @default.
- W3080398302 cites W2606968610 @default.
- W3080398302 cites W2627028493 @default.
- W3080398302 cites W2700309767 @default.
- W3080398302 cites W2704199311 @default.
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- W3080398302 cites W2747423355 @default.
- W3080398302 cites W2747769029 @default.
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- W3080398302 cites W2808570189 @default.
- W3080398302 cites W2884435772 @default.
- W3080398302 cites W2884537568 @default.
- W3080398302 cites W2887577080 @default.
- W3080398302 cites W2902946041 @default.
- W3080398302 cites W2905662727 @default.
- W3080398302 cites W2907564726 @default.
- W3080398302 cites W2909301717 @default.
- W3080398302 cites W2916814431 @default.
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- W3080398302 doi "https://doi.org/10.1016/j.isci.2020.101499" @default.
- W3080398302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7490994" @default.
- W3080398302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32919370" @default.
- W3080398302 hasPublicationYear "2020" @default.
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