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- W3080398320 abstract "Small RNA (sRNA) sequencing has been critical for our understanding of the transcriptional regulation in most biological processes. Nonetheless, the varying biochemical properties of sRNA, such as 59 nucleotide modifications, make many sRNA subspecies incompatible with common protocols for sRNA sequencing. Here we describe 5XP-seq that outlines a novel strategy on how to overcome this limitation. By specifically tagging 59-phosphorylated sRNA (59P sRNA), that enriches miRNA and piRNA, we successfully discriminate these sRNA from all other sRNA species. Our results underscore the importance of more holistic approaches, in which 59 insensitive library strategies are combined with 59 sensitive tagging. Further advances using such strategies will overcome the increasing bias in reports of easily caught sRNA and ensure assessment of the previously overlooked transcriptome." @default.
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- W3080398320 date "2020-08-23" @default.
- W3080398320 modified "2023-09-24" @default.
- W3080398320 title "5'XP sRNA-seq: A simple sequencing method to identify small RNA with and without 5' phosphorylation in a single library from low input samples" @default.
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