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• W3080401977 abstract "Soluble, small amyloid- <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mi>β<!-- β --></mml:mi> </mml:math> oligomers ( <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>A</mml:mi> </mml:mrow> </mml:mrow> <mml:mi>β<!-- β --></mml:mi> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>O</mml:mi> </mml:mrow> </mml:mrow> </mml:math> ) are recognized as significant contributors to the pathology of Alzheimer’s disease (AD). Although drugs for treating AD symptoms have been approved, no therapy targeting amyloid- <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mi>β<!-- β --></mml:mi> </mml:math> ( <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>A</mml:mi> </mml:mrow> </mml:mrow> <mml:mi>β<!-- β --></mml:mi> </mml:math> ) capable of modifying the course of the disease is available. In an effort to develop a label-free method for screening new anti-AD therapeutic agents, we show the use of a surface-enhanced Raman scattering (SERS) active substrate for detecting the interactions between <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>A</mml:mi> </mml:mrow> </mml:mrow> <mml:mi>β<!-- β --></mml:mi> </mml:math> peptides and spin-labeled fluorine (SLF), a peptide aggregation inhibitor. Changes in the peak positions and intensity ratios of two spectral peaks near <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mn>1600</mml:mn> </mml:mrow> </mml:mrow> <mml:mspace width=thickmathspace /> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>c</mml:mi> </mml:mrow> </mml:mrow> <mml:mrow class=MJX-TeXAtom-ORD> <mml:msup> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>m</mml:mi> </mml:mrow> </mml:mrow> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mo>−<!-- − --></mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> and <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mn>2900</mml:mn> </mml:mrow> </mml:mrow> <mml:mspace width=thickmathspace /> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>c</mml:mi> </mml:mrow> </mml:mrow> <mml:mrow class=MJX-TeXAtom-ORD> <mml:msup> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>m</mml:mi> </mml:mrow> </mml:mrow> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mo>−<!-- − --></mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> can be used to monitor the molecular interactions between SLF and <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>A</mml:mi> </mml:mrow> </mml:mrow> <mml:mi>β<!-- β --></mml:mi> </mml:math> . This study demonstrates the potential of SERS spectroscopy for rapidly screening and identifying new anti- <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML display=inline> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mrow class=MJX-TeXAtom-ORD> <mml:mi mathvariant=normal>A</mml:mi> </mml:mrow> </mml:mrow> <mml:mi>β<!-- β --></mml:mi> </mml:math> therapeutic agents." @default.
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• W3080401977 date "2020-08-24" @default.
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• W3080401977 title "Surface-enhanced Raman scattering sensing platform for detecting amyloid-β peptide interaction with an aggregation inhibitor" @default.
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• W3080401977 doi "https://doi.org/10.1364/ao.399307" @default.
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