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- W3080423112 endingPage "218" @default.
- W3080423112 startingPage "205" @default.
- W3080423112 abstract "The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins. The nuclear envelope of mammalian cells opens up during cell division. It is reassembled and associated with chromatin at the end of mitosis when telomeres tether to the nuclear periphery. Lamins, LEM domain proteins, and DNA binding factors, as BAF, contribute to the reorganization of chromatin. In this context, an emerging role is that of the ESCRT complex, a machinery operating in multiple membrane assembly pathways, including nuclear envelope reformation. Research in this area is unraveling how, mechanistically, ESCRTs link to nuclear envelope associated factors as LEM domain proteins. Importantly, ESCRTs work also during interphase for repairing nuclear envelope ruptures. Altogether the advances in this field are giving new clues for the interpretation of diseases implicating nuclear envelope fragility, as laminopathies and cancer.Abbreviations na, not analyzed; ko, knockout; kd, knockdown; NE, nuclear envelope; LEM, LAP2-emerin-MAN1 (LEM)-domain containing proteins; LINC, linker of nucleoskeleton and cytoskeleton complexes; Cyt, cytoplasm; Chr, chromatin; MB, midbody; End, endosomes; Tel, telomeres; INM, inner nuclear membrane; NP, nucleoplasm; NPC, Nuclear Pore Complex; ER, Endoplasmic Reticulum; SPB, spindle pole body." @default.
- W3080423112 created "2020-09-01" @default.
- W3080423112 creator A5000740270 @default.
- W3080423112 creator A5007790566 @default.
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- W3080423112 creator A5025609663 @default.
- W3080423112 creator A5079371643 @default.
- W3080423112 creator A5088657110 @default.
- W3080423112 date "2020-01-01" @default.
- W3080423112 modified "2023-09-27" @default.
- W3080423112 title "Interplay of the nuclear envelope with chromatin in physiology and pathology" @default.
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