Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080429329> ?p ?o ?g. }
- W3080429329 endingPage "567" @default.
- W3080429329 startingPage "540" @default.
- W3080429329 abstract "Various types of transgenic mice carrying either class I or II human leukocyte antigen (HLA) molecules are readily available, and reports describing their use in a variety of studies have been published for more than 30 years. Examples of their use include the discovery of HLA-specific antigens against viral infection as well as the reproduction of HLA-mediated autoimmune diseases for the development of therapeutic strategies. Recently, HLA transgenic mice have been used to reproduce HLA-mediated idiosyncratic drug toxicity (IDT), a rare and unpredictable adverse drug reaction that can result in death. For example, abacavir-induced IDT has successfully been reproduced in HLA-B*57:01 transgenic mice. Several reports using HLA transgenic mice for IDT have proven the utility of this concept for the evaluation of IDT using various HLA allele combinations and drugs. It has become apparent that such models may be a valuable tool to investigate the mechanisms underlying HLA-mediated IDT. This review summarizes the latest findings in the area of HLA transgenic mouse models and discusses the current challenges that must be overcome to maximize the potential of this unique animal model." @default.
- W3080429329 created "2020-09-01" @default.
- W3080429329 creator A5001574389 @default.
- W3080429329 creator A5023107954 @default.
- W3080429329 creator A5027791989 @default.
- W3080429329 creator A5030534386 @default.
- W3080429329 creator A5046331909 @default.
- W3080429329 creator A5055365182 @default.
- W3080429329 date "2020-08-27" @default.
- W3080429329 modified "2023-10-14" @default.
- W3080429329 title "HLA transgenic mice: application in reproducing idiosyncratic drug toxicity" @default.
- W3080429329 cites W1487892464 @default.
- W3080429329 cites W1489578751 @default.
- W3080429329 cites W1522424654 @default.
- W3080429329 cites W1541105559 @default.
- W3080429329 cites W1543555882 @default.
- W3080429329 cites W1547143247 @default.
- W3080429329 cites W1547732107 @default.
- W3080429329 cites W1548085928 @default.
- W3080429329 cites W1549484347 @default.
- W3080429329 cites W1560339503 @default.
- W3080429329 cites W1570193556 @default.
- W3080429329 cites W1595298938 @default.
- W3080429329 cites W1637743236 @default.
- W3080429329 cites W1652840914 @default.
- W3080429329 cites W1656161741 @default.
- W3080429329 cites W1661135362 @default.
- W3080429329 cites W1814199953 @default.
- W3080429329 cites W1902688086 @default.
- W3080429329 cites W1913127820 @default.
- W3080429329 cites W1934755840 @default.
- W3080429329 cites W1945457765 @default.
- W3080429329 cites W1957968460 @default.
- W3080429329 cites W1958830417 @default.
- W3080429329 cites W1963515763 @default.
- W3080429329 cites W1965912489 @default.
- W3080429329 cites W1969210899 @default.
- W3080429329 cites W1970520939 @default.
- W3080429329 cites W1972677079 @default.
- W3080429329 cites W1974201159 @default.
- W3080429329 cites W1975069505 @default.
- W3080429329 cites W1976307335 @default.
- W3080429329 cites W1978829533 @default.
- W3080429329 cites W1979620128 @default.
- W3080429329 cites W1982805265 @default.
- W3080429329 cites W1982922358 @default.
- W3080429329 cites W1983344552 @default.
- W3080429329 cites W1988111543 @default.
- W3080429329 cites W1988829774 @default.
- W3080429329 cites W1989354636 @default.
- W3080429329 cites W1989571264 @default.
- W3080429329 cites W1992731679 @default.
- W3080429329 cites W1993276441 @default.
- W3080429329 cites W1995412268 @default.
- W3080429329 cites W1996017127 @default.
- W3080429329 cites W1997647948 @default.
- W3080429329 cites W1999277880 @default.
- W3080429329 cites W1999587831 @default.
- W3080429329 cites W2002493942 @default.
- W3080429329 cites W2003268732 @default.
- W3080429329 cites W2004776622 @default.
- W3080429329 cites W2004879939 @default.
- W3080429329 cites W2009846038 @default.
- W3080429329 cites W2011639909 @default.
- W3080429329 cites W2012503734 @default.
- W3080429329 cites W2014946834 @default.
- W3080429329 cites W2017321053 @default.
- W3080429329 cites W2020060786 @default.
- W3080429329 cites W2023158651 @default.
- W3080429329 cites W2025023129 @default.
- W3080429329 cites W2025985443 @default.
- W3080429329 cites W2026500013 @default.
- W3080429329 cites W2029208048 @default.
- W3080429329 cites W2029645315 @default.
- W3080429329 cites W2030482265 @default.
- W3080429329 cites W2030510044 @default.
- W3080429329 cites W2032214585 @default.
- W3080429329 cites W2033113075 @default.
- W3080429329 cites W2034207354 @default.
- W3080429329 cites W2039846995 @default.
- W3080429329 cites W2040495100 @default.
- W3080429329 cites W2042642291 @default.
- W3080429329 cites W2043646502 @default.
- W3080429329 cites W2046429382 @default.
- W3080429329 cites W2047134725 @default.
- W3080429329 cites W2048488820 @default.
- W3080429329 cites W2050073477 @default.
- W3080429329 cites W2053580563 @default.
- W3080429329 cites W2053826122 @default.
- W3080429329 cites W2054099278 @default.
- W3080429329 cites W2057021009 @default.
- W3080429329 cites W2059601118 @default.
- W3080429329 cites W2061106786 @default.
- W3080429329 cites W2061433777 @default.
- W3080429329 cites W2064159623 @default.
- W3080429329 cites W2064462489 @default.
- W3080429329 cites W2067249142 @default.
- W3080429329 cites W2069031096 @default.