FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080438064> ?p ?o ?g. }

• W3080438064 endingPage "158" @default.
• W3080438064 startingPage "158" @default.
• W3080438064 abstract "The timely diagnosis and management of patients with suspected ST-segment myocardial infarction (STEMI) or acute coronary syndrome (ACS) in the COVID-19 era is an area of wide concern given variable presentation as well-associated risks of infection to healthcare teams. The recent manuscript by Hamadeh et al,1Hamadeh A Aldujeli A Briedis K Tecson KM Sánchez JS Al Dujeili M Al-Obeidi A Luís J Žaliūnas R Stoler RC McCullough PA Characteristics and outcomes in patients presenting with COVID-19 and ST-segment elevation myocardial infarction.Am J Cardiol. 2020; 131: 1-6Abstract Full Text Full Text PDF PubMed Scopus (67) Google Scholar published in the journal adds to our existing knowledge by reporting the largest, multicenter case series on the clinical presentation, management, and outcomes of patients with symptomatic COVID-19 infection and STEMI.1Hamadeh A Aldujeli A Briedis K Tecson KM Sánchez JS Al Dujeili M Al-Obeidi A Luís J Žaliūnas R Stoler RC McCullough PA Characteristics and outcomes in patients presenting with COVID-19 and ST-segment elevation myocardial infarction.Am J Cardiol. 2020; 131: 1-6Abstract Full Text Full Text PDF PubMed Scopus (67) Google Scholar There are several key findings in this study and we commend the authors on their investigation. However, certain aspects of the study merit attention before definite conclusions can be drawn, especially regarding the high incidence of stent thrombosis in this cohort and advocating broader use of fibrinolytic therapy in healthcare systems where access to primary percutaneous coronary intervention (PCI) is more prevalent. First and foremost, this is a retrospective case study where many known and unknown factors confound the relation being examined. The finding of strikingly high rates of stent thrombosis needs to be interpreted with caution as patients in the PCI cohort were sicker and more likely to present with shock, develop acute respiratory distress syndrome and need mechanical ventilation. Given the smaller sample size of the study, especially the primary PCI cohort, any potential beneficial or harmful effect of a therapy may be amplified. Although the overall proportion of patients with stent thrombosis (21%) in the cohort is concerning, the absolute number (n = 4) is still relatively low. The authors did use the fourth universal definition of myocardial infarction for stent thrombosis, but it will be interesting to know more about angiographic factors in these patients. In our anecdotal practice in a high-volume public healthcare system in the United States, we have managed COVID-19 STEMI patients with primary PCI and used prolonged infusions of cangrelor or GP IIb/IIIa inhibitors after successful reperfusion given the heavy thrombus burden with good outcomes. Second, outcomes in the fibrinolytic group of unsuccessful reperfusion (n = 9/59; 15%) and high incidence of hemorrhagic stroke (n = 5/59, 9%) question both efficacy and safety of fibrinolytic therapy in this cohort. This is also of considerable importance as 2 contemporary case series have suggested that between 30% and 39% of patients who undergo urgent coronary angiography for suspected STEMI in setting of COVID-19 do not have angiographic diagnosis to suggest coronary obstruction,2Stefanini GG Montorfano M Trabattoni D Andreini D Ferrante G Ancona M Metra M Curello Maffeo D Pero G Cacucci M Assanelli E Bellini B Russo F Ielasi A Tespili M Danzi GB Vandoni P Bollati M Barbieri L Oreglia J Lettieri C Cremonesi A Carugo S Reimers B Condorelli G Chieffo A ST-elevation myocardial infarction in patients with COVID-19: clinical and angiographic outcomes.Circulation. 2020; 141: 2113-2116Crossref PubMed Scopus (300) Google Scholar,3Bangalore S Sharma A Slotwiner A Yatskar L Harari R Shah B Ibrahim H Friedman GH Thompson C Alviar CL Chadow HL Fishman GI Reynolds HR Keller N Hochman JS ST-segment elevation in patients with Covid-19 - a case series.N Engl J Med. 2020; 382: 2478-2480Crossref PubMed Scopus (541) Google Scholar which make advocating fibrinolytic therapy for COVID-19 patients who present with suspected STEMI, unnecessary and potentially dangerous. We propose that whenever possible, COVID-19 patients with findings suggestive of STEMI should be transferred to a PCI-capable facility. The recent statement published by the American College of Cardiology (ACC), Society for Cardiovascular Angiography and Interventions (SCAI) and American College of Emergency Physicians (ACEP) recommends primary PCI as the standard of care for COVID-19 patients who present with STEMI.4Mahmud E Dauerman HL Welt FGP Messenger JC Rao SV Grines C Mattu A Kirtane AJ Jauhar R Meraj P Rokos IC Rumsfeld JS Henry TD Management of acute myocardial infarction during the COVID-19 pandemic: a consensus statement from the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology (ACC), and the American College of Emergency Physicians (ACEP) [published online ahead of print, 2020 Apr 20].Catheter Cardiovasc Interv. 2020; (10.1002/ccd.28946)https://doi.org/10.1002/ccd.28946Crossref Scopus (80) Google Scholar It is becoming increasingly apparent that ACS in COVID-19 infected patients is not the same disease process compared with ACS without COVID-19 infection. The dichotomy of both increased mimickers of STEMI as well as a signal of higher thrombus burden in patients with angiographic STEMI adds to the already complex management of COVID-19 patients.2Stefanini GG Montorfano M Trabattoni D Andreini D Ferrante G Ancona M Metra M Curello Maffeo D Pero G Cacucci M Assanelli E Bellini B Russo F Ielasi A Tespili M Danzi GB Vandoni P Bollati M Barbieri L Oreglia J Lettieri C Cremonesi A Carugo S Reimers B Condorelli G Chieffo A ST-elevation myocardial infarction in patients with COVID-19: clinical and angiographic outcomes.Circulation. 2020; 141: 2113-2116Crossref PubMed Scopus (300) Google Scholar,3Bangalore S Sharma A Slotwiner A Yatskar L Harari R Shah B Ibrahim H Friedman GH Thompson C Alviar CL Chadow HL Fishman GI Reynolds HR Keller N Hochman JS ST-segment elevation in patients with Covid-19 - a case series.N Engl J Med. 2020; 382: 2478-2480Crossref PubMed Scopus (541) Google Scholar,5Guo T Fan Y Chen M Wu X Zhang L He T Wang H Wan J Wang X Lu Z Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) [published online ahead of print, 2020 Mar 27].JAMA Cardiol. 2020; 5: 1-8Crossref Scopus (2701) Google Scholar The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper." @default.
• W3080438064 created "2020-09-01" @default.
• W3080438064 creator A5026578587 @default.
• W3080438064 creator A5035047526 @default.
• W3080438064 creator A5053953790 @default.
• W3080438064 creator A5078812233 @default.
• W3080438064 date "2020-11-01" @default.
• W3080438064 modified "2023-10-11" @default.
• W3080438064 title "Primary Percutaneous Coronary Intervention or Fibrinolytic Therapy in COVID 19 Patients Presenting With ST-Segment Elevation Myocardial Infarction" @default.
• W3080438064 cites W3016587927 @default.
• W3080438064 cites W3022384443 @default.
• W3080438064 cites W3038205516 @default.
• W3080438064 doi "https://doi.org/10.1016/j.amjcard.2020.08.021" @default.
• W3080438064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7443085" @default.
• W3080438064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32841613" @default.
• W3080438064 hasPublicationYear "2020" @default.
• W3080438064 type Work @default.
• W3080438064 sameAs 3080438064 @default.
• W3080438064 citedByCount "4" @default.
• W3080438064 countsByYear W30804380642021 @default.
• W3080438064 countsByYear W30804380642023 @default.
• W3080438064 crossrefType "journal-article" @default.
• W3080438064 hasAuthorship W3080438064A5026578587 @default.
• W3080438064 hasAuthorship W3080438064A5035047526 @default.
• W3080438064 hasAuthorship W3080438064A5053953790 @default.
• W3080438064 hasAuthorship W3080438064A5078812233 @default.
• W3080438064 hasBestOaLocation W30804380641 @default.
• W3080438064 hasConcept C126322002 @default.
• W3080438064 hasConcept C164705383 @default.
• W3080438064 hasConcept C2524010 @default.
• W3080438064 hasConcept C2771771 @default.
• W3080438064 hasConcept C2779134260 @default.
• W3080438064 hasConcept C2780400711 @default.
• W3080438064 hasConcept C2910112519 @default.
• W3080438064 hasConcept C2910604149 @default.
• W3080438064 hasConcept C3008058167 @default.
• W3080438064 hasConcept C33923547 @default.
• W3080438064 hasConcept C37054046 @default.
• W3080438064 hasConcept C500558357 @default.
• W3080438064 hasConcept C524204448 @default.
• W3080438064 hasConcept C71924100 @default.
• W3080438064 hasConceptScore W3080438064C126322002 @default.
• W3080438064 hasConceptScore W3080438064C164705383 @default.
• W3080438064 hasConceptScore W3080438064C2524010 @default.
• W3080438064 hasConceptScore W3080438064C2771771 @default.
• W3080438064 hasConceptScore W3080438064C2779134260 @default.
• W3080438064 hasConceptScore W3080438064C2780400711 @default.
• W3080438064 hasConceptScore W3080438064C2910112519 @default.
• W3080438064 hasConceptScore W3080438064C2910604149 @default.
• W3080438064 hasConceptScore W3080438064C3008058167 @default.
• W3080438064 hasConceptScore W3080438064C33923547 @default.
• W3080438064 hasConceptScore W3080438064C37054046 @default.
• W3080438064 hasConceptScore W3080438064C500558357 @default.
• W3080438064 hasConceptScore W3080438064C524204448 @default.
• W3080438064 hasConceptScore W3080438064C71924100 @default.
• W3080438064 hasLocation W30804380641 @default.
• W3080438064 hasLocation W30804380642 @default.
• W3080438064 hasOpenAccess W3080438064 @default.
• W3080438064 hasPrimaryLocation W30804380641 @default.
• W3080438064 hasRelatedWork W2000035377 @default.
• W3080438064 hasRelatedWork W2074213664 @default.
• W3080438064 hasRelatedWork W2082020455 @default.
• W3080438064 hasRelatedWork W2160155483 @default.
• W3080438064 hasRelatedWork W2319761247 @default.
• W3080438064 hasRelatedWork W2762338479 @default.
• W3080438064 hasRelatedWork W2902602806 @default.
• W3080438064 hasRelatedWork W2954812932 @default.
• W3080438064 hasRelatedWork W2970776548 @default.
• W3080438064 hasRelatedWork W4229879789 @default.
• W3080438064 hasVolume "134" @default.
• W3080438064 isParatext "false" @default.
• W3080438064 isRetracted "false" @default.
• W3080438064 magId "3080438064" @default.
• W3080438064 workType "article" @default.