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- W3080450002 abstract "Background: Patients infected with SARS-CoV-2 exhibit a highly variable clinical course, varying from barely discernible signs of disease, to moderate flu-like symptoms and, occasionally, with life-threatening pneumonia and/or cytokine storm. The relationship between the nasopharyngeal virus load, IgA and IgG antibodies to both the S1-RBD-protein and the N-protein as well the neutralizing activity (NAbs) against SARS-CoV-2 in the blood of moderately afflicted Covid-19 patients has not been investigated longitudinally so far.Methods: Several new serological methods to examine these parameters were developed and validated for the longitudinal investigation in three patients of a family which underwent a mild course of COVID-19.Findings: We observed that the virus load had almost completely disappeared after about four weeks, whereas serum antibodies showed a contrasting course. IgA levels to S1-RBD and, to a lesser extent, to the N-protein, peaked about three weeks after clinical disease onset but declined soon thereafter. IgG levels rose continuously, reaching a plateau approximately six weeks after disease onset. NAbs in serum reached a peak about four weeks after disease onset but dropped to a lower level about six weeks later.Interpretation: Our data establishes associations of virus neutralization and a serological immune response foremost against Sars-CoV-2 S1-RDB protein in a longitudinal manner.Funding Statement: This study was partly funded by the University Hospital, Tuebingen, and grants from the Baden-Wurttemberg Foundation and the Deutsche Forschungsgemeinschaft (DFG).Declaration of Interests: The authors declare no conflict of interests. Ethics Approval Statement: This study was approved by the University of Tubingen." @default.
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- W3080450002 date "2020-01-01" @default.
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- W3080450002 title "Longitudinal Analysis of Virus Load, Serum Antibody Levels and Virus Neutralizing Activity <i>In Vitro</i> in Cases with Less Severe COVID-19" @default.
- W3080450002 doi "https://doi.org/10.2139/ssrn.3666854" @default.
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