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- W3080455218 abstract "Abstract Necroptosis, a form of programmed cell death, is characterized by the loss of membrane integrity and release of intracellular contents, the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein (MLKL) upon its phosphorylation. Here we found myofibers committed MLKL-dependent necroptosis after muscle injury. Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1 (RIPK1) or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects. By releasing factors into the muscle stem cell (MuSC) microenvironment, necroptotic myofibers facilitated muscle regeneration. Tenascin-C (TNC), released by necroptotic myofibers, was found to be critical for MuSC proliferation. The temporary expression of TNC in myofibers is tightly controlled by necroptosis; the extracellular release of TNC depends on necroptotic membrane rupture. TNC directly activated EGF receptor (EGFR) signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain. These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration." @default.
- W3080455218 created "2020-09-01" @default.
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- W3080455218 date "2020-08-24" @default.
- W3080455218 modified "2023-10-18" @default.
- W3080455218 title "Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration" @default.
- W3080455218 cites W1523845694 @default.
- W3080455218 cites W1583203048 @default.
- W3080455218 cites W1979032223 @default.
- W3080455218 cites W1980285125 @default.
- W3080455218 cites W1993613360 @default.
- W3080455218 cites W1998983498 @default.
- W3080455218 cites W2001650412 @default.
- W3080455218 cites W2007303185 @default.
- W3080455218 cites W2007398635 @default.
- W3080455218 cites W2013233446 @default.
- W3080455218 cites W2014868340 @default.
- W3080455218 cites W2016957645 @default.
- W3080455218 cites W2017075649 @default.
- W3080455218 cites W2017429680 @default.
- W3080455218 cites W2023122823 @default.
- W3080455218 cites W2023424615 @default.
- W3080455218 cites W2029914169 @default.
- W3080455218 cites W2041272135 @default.
- W3080455218 cites W2044793751 @default.
- W3080455218 cites W2048588387 @default.
- W3080455218 cites W2052605153 @default.
- W3080455218 cites W2060204808 @default.
- W3080455218 cites W2061773099 @default.
- W3080455218 cites W2062110054 @default.
- W3080455218 cites W2062568147 @default.
- W3080455218 cites W2076705364 @default.
- W3080455218 cites W2077292291 @default.
- W3080455218 cites W2077317536 @default.
- W3080455218 cites W2080689645 @default.
- W3080455218 cites W2082556380 @default.
- W3080455218 cites W2083175643 @default.
- W3080455218 cites W2087232320 @default.
- W3080455218 cites W2091363184 @default.
- W3080455218 cites W2092230690 @default.
- W3080455218 cites W2101619182 @default.
- W3080455218 cites W2103511872 @default.
- W3080455218 cites W2112039060 @default.
- W3080455218 cites W2112286041 @default.
- W3080455218 cites W2113228211 @default.
- W3080455218 cites W2118621467 @default.
- W3080455218 cites W2118858477 @default.
- W3080455218 cites W2120626244 @default.
- W3080455218 cites W2124396497 @default.
- W3080455218 cites W2130776456 @default.
- W3080455218 cites W2132161879 @default.
- W3080455218 cites W2149056495 @default.
- W3080455218 cites W2151328705 @default.
- W3080455218 cites W2158662692 @default.
- W3080455218 cites W2265782222 @default.
- W3080455218 cites W2267893954 @default.
- W3080455218 cites W2276992439 @default.
- W3080455218 cites W2336439489 @default.
- W3080455218 cites W2388738573 @default.
- W3080455218 cites W2483928016 @default.
- W3080455218 cites W2500850723 @default.
- W3080455218 cites W2529871702 @default.
- W3080455218 cites W2565805996 @default.
- W3080455218 cites W2615601352 @default.
- W3080455218 cites W2746380570 @default.
- W3080455218 cites W2750390778 @default.
- W3080455218 cites W2761041020 @default.
- W3080455218 cites W2769276755 @default.
- W3080455218 cites W2783401550 @default.
- W3080455218 cites W2790995801 @default.
- W3080455218 cites W2802914881 @default.
- W3080455218 cites W2809972762 @default.
- W3080455218 cites W2883070801 @default.
- W3080455218 cites W2886848193 @default.
- W3080455218 cites W2901410206 @default.
- W3080455218 cites W2902664945 @default.
- W3080455218 cites W2910671651 @default.
- W3080455218 cites W2911725572 @default.
- W3080455218 cites W2942513301 @default.
- W3080455218 cites W2963840693 @default.
- W3080455218 cites W2988348870 @default.