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- W3080456082 abstract "Abstract Whipworms are large metazoan parasites that inhabit distinct multi-intracellular epithelial burrows described as syncytial tunnels, in the large intestine of their hosts. How first-stage larvae invade host epithelia and establish infection remains unclear. Here, we investigate early infection events both using Trichuris muris infections of mice and murine caecaloids, the first in-vitro system for whipworm infection. We show that larvae degrade the mucus layers to access epithelial cells. In early syncytial tunnels, larvae are completely intracellular but woven through multiple live enterocytes and goblet cells. We also use single cell RNA sequencing for the first time to describe the mouse caecum. From infected caeca, the transcriptome data reveal the progression of infection results in cell damage and an expansion of enterocytes with a type-I interferon (IFN) signature, characterised by the expression of Isg15 , instigating the host immune response to the whipworm and tissue repair. Our results unravel intestinal epithelium invasion by whipworms and reveal new specific interactions between the host and the parasite that allow the whipworm to establish its multi-intracellular niche." @default.
- W3080456082 created "2020-09-01" @default.
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- W3080456082 date "2020-08-22" @default.
- W3080456082 modified "2023-10-14" @default.
- W3080456082 title "Defining the early stages of intestinal colonisation by whipworms" @default.
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- W3080456082 doi "https://doi.org/10.1101/2020.08.21.261586" @default.
- W3080456082 hasPublicationYear "2020" @default.
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