FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080484791> ?p ?o ?g. }

• W3080484791 endingPage "4719" @default.
• W3080484791 startingPage "4701" @default.
• W3080484791 abstract "Klotho is a membrane-bound or soluble protein, originally identified as an age-suppressing factor and regulator of mineral metabolism. Klotho deficiency is associated with the development of renal disease, but its role in cardiac function in the context of uraemic cardiomyopathy is unknown.We explored the effects of Klotho on cardiac Ca2+ cycling. We analysed Ca2+ handling in adult cardiomyocytes from Klotho-deficient (kl/kl) mice and from a murine model of 5/6 nephrectomy (Nfx). We also studied the effect of exogenous Klotho supplementation, by chronic recombinant Klotho treatment, or endogenous Klotho overexpression, using transgenic mice overexpressing Klotho (Tg-Kl), on uraemic cardiomyopathy. Hearts from Nfx mice were used to study Ca2+ sensitivity of ryanodine receptors and their phosphorylation state.Cardiomyocytes from kl/kl mice showed decreased amplitude of intracellular Ca2+ transients and cellular shortening together with an increase in pro-arrhythmic Ca2+ events compared with cells from wild-type mice. Cardiomyocytes from Nfx mice exhibited the same impairment in Ca2+ cycling as kl/kl mice. Changes in Nfx cardiomyocytes were explained by higher sensitivity of ryanodine receptors to Ca2+ and their increased phosphorylation at the calmodulin kinase type II and protein kinase A sites. Ca2+ mishandling in Nfx-treated mice was fully prevented by chronic recombinant Klotho administration or transgenic Klotho overexpression.Klotho emerges as an attractive therapeutic tool to improve cardiac Ca2+ mishandling observed in uraemic cardiomyopathy. Strategies that improve Klotho availability are good candidates to protect the heart from functional cardiac alterations in renal disease." @default.
• W3080484791 created "2020-09-01" @default.
• W3080484791 creator A5009906740 @default.
• W3080484791 creator A5010748914 @default.
• W3080484791 creator A5011805055 @default.
• W3080484791 creator A5018193501 @default.
• W3080484791 creator A5030157600 @default.
• W3080484791 creator A5040062593 @default.
• W3080484791 creator A5040352999 @default.
• W3080484791 creator A5059623295 @default.
• W3080484791 creator A5076052344 @default.
• W3080484791 creator A5083020535 @default.
• W3080484791 creator A5090201226 @default.
• W3080484791 date "2020-09-15" @default.
• W3080484791 modified "2023-10-18" @default.
• W3080484791 title "Enhanced Klotho availability protects against cardiac dysfunction induced by uraemic cardiomyopathy by regulating Ca ²⁺ handling" @default.
• W3080484791 cites W1548046295 @default.
• W3080484791 cites W1902275238 @default.
• W3080484791 cites W1965171392 @default.
• W3080484791 cites W1966074338 @default.
• W3080484791 cites W1975483501 @default.
• W3080484791 cites W1976544899 @default.
• W3080484791 cites W1977645780 @default.
• W3080484791 cites W1978114446 @default.
• W3080484791 cites W1984733648 @default.
• W3080484791 cites W1985753282 @default.
• W3080484791 cites W1993621156 @default.
• W3080484791 cites W2015897555 @default.
• W3080484791 cites W2033473682 @default.
• W3080484791 cites W2045516356 @default.
• W3080484791 cites W2050824263 @default.
• W3080484791 cites W2051997552 @default.
• W3080484791 cites W2073789348 @default.
• W3080484791 cites W2077322264 @default.
• W3080484791 cites W2078730571 @default.
• W3080484791 cites W2082112477 @default.
• W3080484791 cites W2084265884 @default.
• W3080484791 cites W2091948921 @default.
• W3080484791 cites W2107420262 @default.
• W3080484791 cites W2114360920 @default.
• W3080484791 cites W2114768048 @default.
• W3080484791 cites W2120126332 @default.
• W3080484791 cites W2120129493 @default.
• W3080484791 cites W2122031584 @default.
• W3080484791 cites W2127915809 @default.
• W3080484791 cites W2128499270 @default.
• W3080484791 cites W2132410244 @default.
• W3080484791 cites W2145563296 @default.
• W3080484791 cites W2145632027 @default.
• W3080484791 cites W2152330606 @default.
• W3080484791 cites W2152732984 @default.
• W3080484791 cites W2166385931 @default.
• W3080484791 cites W2166529567 @default.
• W3080484791 cites W2192080449 @default.
• W3080484791 cites W2268697086 @default.
• W3080484791 cites W2332885220 @default.
• W3080484791 cites W2346914972 @default.
• W3080484791 cites W2408344994 @default.
• W3080484791 cites W2491278542 @default.
• W3080484791 cites W2528815425 @default.
• W3080484791 cites W2583017311 @default.
• W3080484791 cites W2583031047 @default.
• W3080484791 cites W2617933574 @default.
• W3080484791 cites W2770362275 @default.
• W3080484791 cites W2791419854 @default.
• W3080484791 cites W2792530460 @default.
• W3080484791 cites W2809521777 @default.
• W3080484791 cites W2884976020 @default.
• W3080484791 cites W2908741319 @default.
• W3080484791 cites W2914222783 @default.
• W3080484791 cites W2917518980 @default.
• W3080484791 cites W2943071095 @default.
• W3080484791 cites W2953345536 @default.
• W3080484791 cites W2985450688 @default.
• W3080484791 cites W2985843002 @default.
• W3080484791 cites W2987709465 @default.
• W3080484791 cites W2987819628 @default.
• W3080484791 cites W3042519295 @default.
• W3080484791 cites W3047879827 @default.
• W3080484791 cites W3080484791 @default.
• W3080484791 cites W4236357753 @default.
• W3080484791 doi "https://doi.org/10.1111/bph.15235" @default.
• W3080484791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7520447" @default.
• W3080484791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32830863" @default.
• W3080484791 hasPublicationYear "2020" @default.
• W3080484791 type Work @default.
• W3080484791 sameAs 3080484791 @default.
• W3080484791 citedByCount "23" @default.
• W3080484791 countsByYear W30804847912020 @default.
• W3080484791 countsByYear W30804847912021 @default.
• W3080484791 countsByYear W30804847912022 @default.
• W3080484791 countsByYear W30804847912023 @default.
• W3080484791 crossrefType "journal-article" @default.
• W3080484791 hasAuthorship W3080484791A5009906740 @default.
• W3080484791 hasAuthorship W3080484791A5010748914 @default.
• W3080484791 hasAuthorship W3080484791A5011805055 @default.
• W3080484791 hasAuthorship W3080484791A5018193501 @default.
• W3080484791 hasAuthorship W3080484791A5030157600 @default.

• next