FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080486041> ?p ?o ?g. }

• W3080486041 endingPage "1060" @default.
• W3080486041 startingPage "1053" @default.
• W3080486041 abstract "Objective To evaluate the impact of faecal immunochemical testing (FIT) prioritisation to mitigate the impact of delays in the colorectal cancer (CRC) urgent diagnostic (2-week-wait (2WW)) pathway consequent from the COVID-19 pandemic. Design We modelled the reduction in CRC survival and life years lost resultant from per-patient delays of 2–6 months in the 2WW pathway. We stratified by age group, individual-level benefit in CRC survival versus age-specific nosocomial COVID-19–related fatality per referred patient undergoing colonoscopy. We modelled mitigation strategies using thresholds of FIT triage of 2, 10 and 150 µg Hb/g to prioritise 2WW referrals for colonoscopy. To construct the underlying models, we employed 10-year net CRC survival for England 2008–2017, 2WW pathway CRC case and referral volumes and per-day-delay HRs generated from observational studies of diagnosis-to-treatment interval. Results Delay of 2/4/6 months across all 11 266 patients with CRC diagnosed per typical year via the 2WW pathway were estimated to result in 653/1419/2250 attributable deaths and loss of 9214/20 315/32 799 life years. Risk–benefit from urgent investigatory referral is particularly sensitive to nosocomial COVID-19 rates for patients aged >60. Prioritisation out of delay for the 18% of symptomatic referrals with FIT >10 µg Hb/g would avoid 89% of these deaths attributable to presentational/diagnostic delay while reducing immediate requirement for colonoscopy by >80%. Conclusions Delays in the pathway to CRC diagnosis and treatment have potential to cause significant mortality and loss of life years. FIT triage of symptomatic patients in primary care could streamline access to colonoscopy, reduce delays for true-positive CRC cases and reduce nosocomial COVID-19 mortality in older true-negative 2WW referrals. However, this strategy offers benefit only in short-term rationalisation of limited endoscopy services: the appreciable false-negative rate of FIT in symptomatic patients means most colonoscopies will still be required." @default.
• W3080486041 created "2020-09-01" @default.
• W3080486041 creator A5002719979 @default.
• W3080486041 creator A5018508010 @default.
• W3080486041 creator A5019036615 @default.
• W3080486041 creator A5022550644 @default.
• W3080486041 creator A5023433214 @default.
• W3080486041 creator A5024696344 @default.
• W3080486041 creator A5027677384 @default.
• W3080486041 creator A5030069710 @default.
• W3080486041 creator A5035469816 @default.
• W3080486041 creator A5036190293 @default.
• W3080486041 creator A5039801732 @default.
• W3080486041 creator A5040393876 @default.
• W3080486041 creator A5040557330 @default.
• W3080486041 creator A5045748016 @default.
• W3080486041 creator A5063770209 @default.
• W3080486041 creator A5067228080 @default.
• W3080486041 creator A5069389082 @default.
• W3080486041 creator A5071766693 @default.
• W3080486041 creator A5078309724 @default.
• W3080486041 creator A5078525701 @default.
• W3080486041 creator A5078679276 @default.
• W3080486041 creator A5080926764 @default.
• W3080486041 date "2020-08-27" @default.
• W3080486041 modified "2023-10-18" @default.
• W3080486041 title "Prioritisation by FIT to mitigate the impact of delays in the 2-week wait colorectal cancer referral pathway during the COVID-19 pandemic: a UK modelling study" @default.
• W3080486041 cites W2025232681 @default.
• W3080486041 cites W2066897205 @default.
• W3080486041 cites W2068164128 @default.
• W3080486041 cites W2070151882 @default.
• W3080486041 cites W2077583437 @default.
• W3080486041 cites W2148250104 @default.
• W3080486041 cites W2159699328 @default.
• W3080486041 cites W2402516431 @default.
• W3080486041 cites W2531472381 @default.
• W3080486041 cites W2610101694 @default.
• W3080486041 cites W2743632419 @default.
• W3080486041 cites W2744987279 @default.
• W3080486041 cites W2770600463 @default.
• W3080486041 cites W2790554721 @default.
• W3080486041 cites W2910690011 @default.
• W3080486041 cites W2989403087 @default.
• W3080486041 cites W3013007496 @default.
• W3080486041 cites W3023906352 @default.
• W3080486041 cites W3024048939 @default.
• W3080486041 cites W3025323637 @default.
• W3080486041 cites W3026764413 @default.
• W3080486041 cites W3042226836 @default.
• W3080486041 doi "https://doi.org/10.1136/gutjnl-2020-321650" @default.
• W3080486041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7447105" @default.
• W3080486041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32855306" @default.
• W3080486041 hasPublicationYear "2020" @default.
• W3080486041 type Work @default.
• W3080486041 sameAs 3080486041 @default.
• W3080486041 citedByCount "54" @default.
• W3080486041 countsByYear W30804860412020 @default.
• W3080486041 countsByYear W30804860412021 @default.
• W3080486041 countsByYear W30804860412022 @default.
• W3080486041 countsByYear W30804860412023 @default.
• W3080486041 crossrefType "journal-article" @default.
• W3080486041 hasAuthorship W3080486041A5002719979 @default.
• W3080486041 hasAuthorship W3080486041A5018508010 @default.
• W3080486041 hasAuthorship W3080486041A5019036615 @default.
• W3080486041 hasAuthorship W3080486041A5022550644 @default.
• W3080486041 hasAuthorship W3080486041A5023433214 @default.
• W3080486041 hasAuthorship W3080486041A5024696344 @default.
• W3080486041 hasAuthorship W3080486041A5027677384 @default.
• W3080486041 hasAuthorship W3080486041A5030069710 @default.
• W3080486041 hasAuthorship W3080486041A5035469816 @default.
• W3080486041 hasAuthorship W3080486041A5036190293 @default.
• W3080486041 hasAuthorship W3080486041A5039801732 @default.
• W3080486041 hasAuthorship W3080486041A5040393876 @default.
• W3080486041 hasAuthorship W3080486041A5040557330 @default.
• W3080486041 hasAuthorship W3080486041A5045748016 @default.
• W3080486041 hasAuthorship W3080486041A5063770209 @default.
• W3080486041 hasAuthorship W3080486041A5067228080 @default.
• W3080486041 hasAuthorship W3080486041A5069389082 @default.
• W3080486041 hasAuthorship W3080486041A5071766693 @default.
• W3080486041 hasAuthorship W3080486041A5078309724 @default.
• W3080486041 hasAuthorship W3080486041A5078525701 @default.
• W3080486041 hasAuthorship W3080486041A5078679276 @default.
• W3080486041 hasAuthorship W3080486041A5080926764 @default.
• W3080486041 hasBestOaLocation W30804860411 @default.
• W3080486041 hasConcept C121608353 @default.
• W3080486041 hasConcept C126322002 @default.
• W3080486041 hasConcept C194828623 @default.
• W3080486041 hasConcept C23131810 @default.
• W3080486041 hasConcept C2776135927 @default.
• W3080486041 hasConcept C2777120189 @default.
• W3080486041 hasConcept C2778435480 @default.
• W3080486041 hasConcept C2779134260 @default.
• W3080486041 hasConcept C3008058167 @default.
• W3080486041 hasConcept C512399662 @default.
• W3080486041 hasConcept C524204448 @default.
• W3080486041 hasConcept C526805850 @default.
• W3080486041 hasConcept C71924100 @default.
• W3080486041 hasConcept C89623803 @default.

• next