FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080488032> ?p ?o ?g. }

• W3080488032 abstract "In a cohort of 319 individuals with long-duration type 1 diabetes (T1D), we found that 89.9% of participants with undetectable stimulated C-peptide had measurable fasting or stimulated serum proinsulin (1). To ensure the validity of our results, we performed rigorous validation of the Millipore human intact and Des (31,32) proinsulin radioimmunoassay that included spike-in experiments using insulin, C-peptide, and proinsulin; independent calculation of a lower limit of detection; assessment of inter- and intra-assay coefficients of variation; analysis of linearity of dilution; analysis of samples pre- and postpancreatectomy; analysis of effects of increased insulin autoantibody titers; and quantitative validation of our findings using mass spectrometry (1). The letter by Steenkamp et al. (2) in response to our article suggests the Millipore assay may overestimate proinsulin levels compared with the ALPCO STELLUX human total proinsulin ELISA. The authors’ concerns are based on their finding that, using the ALPCO assay, proinsulin was detected in only 16% of random samples from a smaller subset of C-peptide–negative individuals from the same T1D Exchange Residual C-peptide Study (3).Quantitative immunoassay performance differences between different assay platforms are not surprising due to antibody interactions with different epitopes on native antigens …" @default.
• W3080488032 created "2020-09-01" @default.
• W3080488032 creator A5004867091 @default.
• W3080488032 creator A5015059732 @default.
• W3080488032 creator A5015522062 @default.
• W3080488032 creator A5015843387 @default.
• W3080488032 creator A5020555978 @default.
• W3080488032 creator A5031560696 @default.
• W3080488032 creator A5032008622 @default.
• W3080488032 creator A5035387736 @default.
• W3080488032 creator A5035704912 @default.
• W3080488032 creator A5045595295 @default.
• W3080488032 creator A5048233009 @default.
• W3080488032 creator A5051059014 @default.
• W3080488032 creator A5055641574 @default.
• W3080488032 creator A5058145167 @default.
• W3080488032 creator A5063131669 @default.
• W3080488032 creator A5063732167 @default.
• W3080488032 creator A5067464347 @default.
• W3080488032 creator A5072170846 @default.
• W3080488032 creator A5075235007 @default.
• W3080488032 creator A5076482116 @default.
• W3080488032 creator A5081549506 @default.
• W3080488032 creator A5086802524 @default.
• W3080488032 date "2019-05-01" @default.
• W3080488032 modified "2023-09-26" @default.
• W3080488032 title "Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258–264" @default.
• W3080488032 hasPublicationYear "2019" @default.
• W3080488032 type Work @default.
• W3080488032 sameAs 3080488032 @default.
• W3080488032 citedByCount "0" @default.
• W3080488032 crossrefType "journal-article" @default.
• W3080488032 hasAuthorship W3080488032A5004867091 @default.
• W3080488032 hasAuthorship W3080488032A5015059732 @default.
• W3080488032 hasAuthorship W3080488032A5015522062 @default.
• W3080488032 hasAuthorship W3080488032A5015843387 @default.
• W3080488032 hasAuthorship W3080488032A5020555978 @default.
• W3080488032 hasAuthorship W3080488032A5031560696 @default.
• W3080488032 hasAuthorship W3080488032A5032008622 @default.
• W3080488032 hasAuthorship W3080488032A5035387736 @default.
• W3080488032 hasAuthorship W3080488032A5035704912 @default.
• W3080488032 hasAuthorship W3080488032A5045595295 @default.
• W3080488032 hasAuthorship W3080488032A5048233009 @default.
• W3080488032 hasAuthorship W3080488032A5051059014 @default.
• W3080488032 hasAuthorship W3080488032A5055641574 @default.
• W3080488032 hasAuthorship W3080488032A5058145167 @default.
• W3080488032 hasAuthorship W3080488032A5063131669 @default.
• W3080488032 hasAuthorship W3080488032A5063732167 @default.
• W3080488032 hasAuthorship W3080488032A5067464347 @default.
• W3080488032 hasAuthorship W3080488032A5072170846 @default.
• W3080488032 hasAuthorship W3080488032A5075235007 @default.
• W3080488032 hasAuthorship W3080488032A5076482116 @default.
• W3080488032 hasAuthorship W3080488032A5081549506 @default.
• W3080488032 hasAuthorship W3080488032A5086802524 @default.
• W3080488032 hasConcept C126322002 @default.
• W3080488032 hasConcept C134018914 @default.
• W3080488032 hasConcept C147483822 @default.
• W3080488032 hasConcept C159654299 @default.
• W3080488032 hasConcept C163764329 @default.
• W3080488032 hasConcept C176685330 @default.
• W3080488032 hasConcept C185592680 @default.
• W3080488032 hasConcept C195616568 @default.
• W3080488032 hasConcept C203014093 @default.
• W3080488032 hasConcept C2778875212 @default.
• W3080488032 hasConcept C2779281246 @default.
• W3080488032 hasConcept C2779306644 @default.
• W3080488032 hasConcept C2780420688 @default.
• W3080488032 hasConcept C2781232474 @default.
• W3080488032 hasConcept C43617362 @default.
• W3080488032 hasConcept C55493867 @default.
• W3080488032 hasConcept C555293320 @default.
• W3080488032 hasConcept C71924100 @default.
• W3080488032 hasConcept C89838059 @default.
• W3080488032 hasConcept C90061646 @default.
• W3080488032 hasConceptScore W3080488032C126322002 @default.
• W3080488032 hasConceptScore W3080488032C134018914 @default.
• W3080488032 hasConceptScore W3080488032C147483822 @default.
• W3080488032 hasConceptScore W3080488032C159654299 @default.
• W3080488032 hasConceptScore W3080488032C163764329 @default.
• W3080488032 hasConceptScore W3080488032C176685330 @default.
• W3080488032 hasConceptScore W3080488032C185592680 @default.
• W3080488032 hasConceptScore W3080488032C195616568 @default.
• W3080488032 hasConceptScore W3080488032C203014093 @default.
• W3080488032 hasConceptScore W3080488032C2778875212 @default.
• W3080488032 hasConceptScore W3080488032C2779281246 @default.
• W3080488032 hasConceptScore W3080488032C2779306644 @default.
• W3080488032 hasConceptScore W3080488032C2780420688 @default.
• W3080488032 hasConceptScore W3080488032C2781232474 @default.
• W3080488032 hasConceptScore W3080488032C43617362 @default.
• W3080488032 hasConceptScore W3080488032C55493867 @default.
• W3080488032 hasConceptScore W3080488032C555293320 @default.
• W3080488032 hasConceptScore W3080488032C71924100 @default.
• W3080488032 hasConceptScore W3080488032C89838059 @default.
• W3080488032 hasConceptScore W3080488032C90061646 @default.
• W3080488032 hasLocation W30804880321 @default.
• W3080488032 hasOpenAccess W3080488032 @default.
• W3080488032 hasPrimaryLocation W30804880321 @default.
• W3080488032 hasRelatedWork W1963502100 @default.
• W3080488032 hasRelatedWork W1965974070 @default.
• W3080488032 hasRelatedWork W2064683794 @default.

• next