Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080490623> ?p ?o ?g. }
- W3080490623 abstract "ABSTRACT The pediatric extra-cranial tumor neuroblastoma (NB) is characterised by a low mutation burden while copy number alterations are present in most high-risk cases. We identified SOX11 as a strong lineage dependency transcription factor in adrenergic NB based on recurrent chromosome 2p focal gains and amplifications, its specific expression in the normal sympatho-adrenal lineage and adrenergic NBs and its regulation by multiple adrenergic specific cis-interacting (super-)enhancers. Adrenergic NBs are strongly dependent on high SOX11 expression levels for growth and proliferation. Through genome-wide DNA-binding and transcriptome analysis, we identified and validated functional SOX11 target genes, several of which implicated in chromatin remodeling and epigenetic modification. SOX11 controls chromatin accessibility predominantly affecting distal adrenergic lineage-specific enhancers marked by binding sites of the adrenergic core regulatory circuitry. During normal sympathoblast differentiation we find expression of SOX11 prior to members of the adrenergic core regulatory circuitry. Given the broad control of SOX11 of multiple epigenetic regulatory complexes and its presumed pioneer factor function, we propose that adrenergic NB cells have co-opted the normal role of SOX11 as a crucial regulator of chromatin accessibility and cell identity." @default.
- W3080490623 created "2020-09-01" @default.
- W3080490623 creator A5001058062 @default.
- W3080490623 creator A5001937241 @default.
- W3080490623 creator A5015213142 @default.
- W3080490623 creator A5016474042 @default.
- W3080490623 creator A5018868727 @default.
- W3080490623 creator A5023357394 @default.
- W3080490623 creator A5026950879 @default.
- W3080490623 creator A5029457295 @default.
- W3080490623 creator A5032769404 @default.
- W3080490623 creator A5034282785 @default.
- W3080490623 creator A5037947455 @default.
- W3080490623 creator A5044156327 @default.
- W3080490623 creator A5045817336 @default.
- W3080490623 creator A5047291368 @default.
- W3080490623 creator A5049733980 @default.
- W3080490623 creator A5049961636 @default.
- W3080490623 creator A5051327187 @default.
- W3080490623 creator A5060237299 @default.
- W3080490623 creator A5061831442 @default.
- W3080490623 creator A5062201304 @default.
- W3080490623 creator A5064588631 @default.
- W3080490623 creator A5066021296 @default.
- W3080490623 creator A5073525735 @default.
- W3080490623 creator A5073903716 @default.
- W3080490623 creator A5078982772 @default.
- W3080490623 creator A5087988858 @default.
- W3080490623 creator A5091191169 @default.
- W3080490623 date "2020-08-21" @default.
- W3080490623 modified "2023-10-14" @default.
- W3080490623 title "SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma" @default.
- W3080490623 cites W1988575240 @default.
- W3080490623 cites W1992241731 @default.
- W3080490623 cites W2004966039 @default.
- W3080490623 cites W2014677321 @default.
- W3080490623 cites W2024304348 @default.
- W3080490623 cites W2028368645 @default.
- W3080490623 cites W2062500929 @default.
- W3080490623 cites W2076861711 @default.
- W3080490623 cites W2100449472 @default.
- W3080490623 cites W2101851382 @default.
- W3080490623 cites W2103619902 @default.
- W3080490623 cites W2114396355 @default.
- W3080490623 cites W2121647859 @default.
- W3080490623 cites W2145927254 @default.
- W3080490623 cites W2152259980 @default.
- W3080490623 cites W2161289668 @default.
- W3080490623 cites W2165551261 @default.
- W3080490623 cites W2262709833 @default.
- W3080490623 cites W2304215759 @default.
- W3080490623 cites W2591968025 @default.
- W3080490623 cites W2702680930 @default.
- W3080490623 cites W2726594986 @default.
- W3080490623 cites W2735132087 @default.
- W3080490623 cites W2738563754 @default.
- W3080490623 cites W2765567136 @default.
- W3080490623 cites W2790674934 @default.
- W3080490623 cites W2794248491 @default.
- W3080490623 cites W2805557625 @default.
- W3080490623 cites W2810804581 @default.
- W3080490623 cites W2835430319 @default.
- W3080490623 cites W2886522065 @default.
- W3080490623 cites W2898532074 @default.
- W3080490623 cites W2901753666 @default.
- W3080490623 cites W2905197516 @default.
- W3080490623 cites W2934396339 @default.
- W3080490623 cites W2969895325 @default.
- W3080490623 cites W2971840355 @default.
- W3080490623 cites W3018363245 @default.
- W3080490623 cites W3024426968 @default.
- W3080490623 cites W3098116341 @default.
- W3080490623 cites W4211147182 @default.
- W3080490623 doi "https://doi.org/10.1101/2020.08.21.261131" @default.
- W3080490623 hasPublicationYear "2020" @default.
- W3080490623 type Work @default.
- W3080490623 sameAs 3080490623 @default.
- W3080490623 citedByCount "6" @default.
- W3080490623 countsByYear W30804906232021 @default.
- W3080490623 countsByYear W30804906232022 @default.
- W3080490623 countsByYear W30804906232023 @default.
- W3080490623 crossrefType "posted-content" @default.
- W3080490623 hasAuthorship W3080490623A5001058062 @default.
- W3080490623 hasAuthorship W3080490623A5001937241 @default.
- W3080490623 hasAuthorship W3080490623A5015213142 @default.
- W3080490623 hasAuthorship W3080490623A5016474042 @default.
- W3080490623 hasAuthorship W3080490623A5018868727 @default.
- W3080490623 hasAuthorship W3080490623A5023357394 @default.
- W3080490623 hasAuthorship W3080490623A5026950879 @default.
- W3080490623 hasAuthorship W3080490623A5029457295 @default.
- W3080490623 hasAuthorship W3080490623A5032769404 @default.
- W3080490623 hasAuthorship W3080490623A5034282785 @default.
- W3080490623 hasAuthorship W3080490623A5037947455 @default.
- W3080490623 hasAuthorship W3080490623A5044156327 @default.
- W3080490623 hasAuthorship W3080490623A5045817336 @default.
- W3080490623 hasAuthorship W3080490623A5047291368 @default.
- W3080490623 hasAuthorship W3080490623A5049733980 @default.
- W3080490623 hasAuthorship W3080490623A5049961636 @default.
- W3080490623 hasAuthorship W3080490623A5051327187 @default.
- W3080490623 hasAuthorship W3080490623A5060237299 @default.