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• W3080493980 abstract "The prodrug concept is a very useful approach for the optimization of ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties of pharmacologically active moieties to increase their utilization by patients and to increase the bioavailability of these pharmacologically active moieties. The physicochemical, biological, and organoleptic properties of the drug substances can be modified to increase the therapeutic efficacy, reduce toxicity, and increase patient compliance. The term “prodrug” can be defined as a chemically modified inert form of an active drug, which upon administration into the body, becomes activated by enzymatic or chemical reaction to form an active drug that is responsible for therapeutic activity. Although prodrugs have the advantages of overcoming issues associated with parent drugs, they have been considered to have less therapeutic activity than the parent drug. The prodrug must release active drug and cross-linked promoiety before, during, after absorption, or within specific target tissue depending upon the purpose of prodrug strategy. Nowadays, a prodrug methodology is considered the most favorable site-specific drug delivery strategy that is applied to deliver a drug substance to a target site or target organ. Since 1960, there has been a tremendous increase in the use of prodrugs in the field of drug discovery and development. It has been estimated that about 10% of the total marketed drugs are prodrugs. In the year 2000–2008, a total of 20% of small molecular weight approved drugs were prodrugs. In the last 10 years, a total of 31 prodrugs were among the 249 new chemical entities approved." @default.
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• W3080493980 date "2020-01-01" @default.
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• W3080493980 title "Prodrug design for improving the biopharmaceutical properties of therapeutic drugs" @default.
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