Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080496437> ?p ?o ?g. }
- W3080496437 abstract "ABSTRACT The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE on LOAD risk and endophenotypes have yet to be explained. In this Review, we revisit the different aspects of APOE involvement in neurodegeneration and neurological diseases, with particular attention to sex differences in the contribution of APOE to LOAD susceptibility. We discuss the role of APOE in a broader range of age-related neurodegenerative diseases, and summarize the biological factors linking APOE to sex hormones, drawing on supportive findings from rodent models to identify major mechanistic themes underlying the exacerbation of LOAD-associated neurodegeneration and pathology in the female brain. Additionally, we list sex-by-genotype interactions identified across neurodegenerative diseases, proposing APOE variants as a shared etiology for sex differences in the manifestation of these diseases. Finally, we present recent advancements in ‘omics’ technologies, which provide a new platform for more in-depth investigations of how dysregulation of this gene affects the development and progression of neurodegenerative diseases. Collectively, the evidence summarized in this Review highlights the interplay between APOE and sex as a key factor in the etiology of LOAD and other age-related neurodegenerative diseases. We emphasize the importance of careful examination of sex as a contributing factor in studying the underpinning genetics of neurodegenerative diseases in general, but particularly for LOAD." @default.
- W3080496437 created "2020-09-01" @default.
- W3080496437 creator A5022113814 @default.
- W3080496437 creator A5029584856 @default.
- W3080496437 creator A5074151999 @default.
- W3080496437 date "2020-08-01" @default.
- W3080496437 modified "2023-10-17" @default.
- W3080496437 title "Sex-dependent effect of <i>APOE</i> on Alzheimer's disease and other age-related neurodegenerative disorders" @default.
- W3080496437 cites W1014881830 @default.
- W3080496437 cites W1495814806 @default.
- W3080496437 cites W1502314515 @default.
- W3080496437 cites W1517571340 @default.
- W3080496437 cites W1528661679 @default.
- W3080496437 cites W1529259401 @default.
- W3080496437 cites W1563459863 @default.
- W3080496437 cites W1576427485 @default.
- W3080496437 cites W1601326205 @default.
- W3080496437 cites W1620426675 @default.
- W3080496437 cites W1622703765 @default.
- W3080496437 cites W1668850892 @default.
- W3080496437 cites W1756696014 @default.
- W3080496437 cites W1848517268 @default.
- W3080496437 cites W1854922036 @default.
- W3080496437 cites W1882553787 @default.
- W3080496437 cites W1902724419 @default.
- W3080496437 cites W1913092771 @default.
- W3080496437 cites W1956968080 @default.
- W3080496437 cites W1963542234 @default.
- W3080496437 cites W1963809989 @default.
- W3080496437 cites W1966860490 @default.
- W3080496437 cites W1969036616 @default.
- W3080496437 cites W1969050262 @default.
- W3080496437 cites W1970227809 @default.
- W3080496437 cites W1971797125 @default.
- W3080496437 cites W1972648551 @default.
- W3080496437 cites W1972969270 @default.
- W3080496437 cites W1973486433 @default.
- W3080496437 cites W1974878596 @default.
- W3080496437 cites W1975432554 @default.
- W3080496437 cites W1976832883 @default.
- W3080496437 cites W1977434686 @default.
- W3080496437 cites W1977919674 @default.
- W3080496437 cites W1979536020 @default.
- W3080496437 cites W1983245034 @default.
- W3080496437 cites W1985582661 @default.
- W3080496437 cites W1986973693 @default.
- W3080496437 cites W1988368483 @default.
- W3080496437 cites W1990674818 @default.
- W3080496437 cites W1992393512 @default.
- W3080496437 cites W1993241967 @default.
- W3080496437 cites W1993365031 @default.
- W3080496437 cites W1993571512 @default.
- W3080496437 cites W1993629125 @default.
- W3080496437 cites W1994543234 @default.
- W3080496437 cites W1994722287 @default.
- W3080496437 cites W1994839137 @default.
- W3080496437 cites W1996249619 @default.
- W3080496437 cites W1997783602 @default.
- W3080496437 cites W1998007696 @default.
- W3080496437 cites W1998165644 @default.
- W3080496437 cites W1998494497 @default.
- W3080496437 cites W1998772259 @default.
- W3080496437 cites W1999043117 @default.
- W3080496437 cites W1999864873 @default.
- W3080496437 cites W2000288492 @default.
- W3080496437 cites W2001400280 @default.
- W3080496437 cites W2001688761 @default.
- W3080496437 cites W2002752208 @default.
- W3080496437 cites W2003402014 @default.
- W3080496437 cites W2003627629 @default.
- W3080496437 cites W2004739315 @default.
- W3080496437 cites W2006117764 @default.
- W3080496437 cites W2006205159 @default.
- W3080496437 cites W2006599070 @default.
- W3080496437 cites W2006957728 @default.
- W3080496437 cites W2007326249 @default.
- W3080496437 cites W2007340922 @default.
- W3080496437 cites W2008543060 @default.
- W3080496437 cites W2010121586 @default.
- W3080496437 cites W2011506847 @default.
- W3080496437 cites W2011598710 @default.
- W3080496437 cites W2012420892 @default.
- W3080496437 cites W2012568539 @default.
- W3080496437 cites W2013452556 @default.
- W3080496437 cites W2017079501 @default.
- W3080496437 cites W2020266809 @default.
- W3080496437 cites W2021181758 @default.
- W3080496437 cites W2021411451 @default.
- W3080496437 cites W2021977705 @default.
- W3080496437 cites W2022854533 @default.
- W3080496437 cites W2025078069 @default.
- W3080496437 cites W2025585440 @default.
- W3080496437 cites W2027439763 @default.
- W3080496437 cites W2029424321 @default.
- W3080496437 cites W2029616852 @default.
- W3080496437 cites W2030651122 @default.
- W3080496437 cites W2030949461 @default.
- W3080496437 cites W2031762899 @default.
- W3080496437 cites W2032596564 @default.
- W3080496437 cites W2033865304 @default.