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• W3080502785 abstract "Chitin is an important part of the fungal cell wall, but is not found in plants and mammals, so chitin synthase (CHS) can be a green fungicide target. In this paper, 35 maleimide compounds were designed and synthesized as CHS inhibitors. All the screened compounds showed different degrees of CHS inhibitory activity and antifungal activity in vitro. In particular, the half–inhibitory concentration (IC50) value of compound 20 on CHS was 0.12 mM, and the inhibitory effect was better than that of the control polyoxin B (IC50 = 0.19 mM). At the same time, this compound also showed good antifungal activity and has further development value." @default.
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• W3080502785 date "2020-08-22" @default.
• W3080502785 modified "2023-09-23" @default.
• W3080502785 title "Screening and Application of Chitin Synthase Inhibitors" @default.
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• W3080502785 doi "https://doi.org/10.3390/pr8091029" @default.
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