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• W3080508052 endingPage "141893" @default.
• W3080508052 startingPage "141893" @default.
• W3080508052 abstract "We evaluated farmworkers exposed to pesticides and individuals with no history of occupational exposure to pesticides. It was performed the comet assay to evaluate DNA damage. The immunophenotyping of TCD4+ lymphocyte subpopulations in peripheral blood was performed by flow cytometry. The single nucleotide polymorphisms (SNPs) in PON1, XRCC1, IL6, IL6R, TNF-α, and MIR137 genes were evaluated by real-time PCR. The exposed group was composed mostly by males (69.44%), with direct exposure to pesticides (56%) and with an average age range of 46 ± 13.89 years, being that 58.3% of farmworkers directly exposed to pesticides and reported the full use of personal protective equipment (PPE). DNA damage was greater in the exposed group (p < 0.05), reinforced by the use of PPE to denote a lower degree of DNA damage (p = 0.002). In this context, in the exposed group, we demonstrated that the use of PPE, age, gender and intoxication events were the variables that most contributed to increase DNA damage (p < 0.0001). Besides, the exposed group showed a significant increase in the subpopulations of T lymphocytes CD3+CD4+ (p < 0.05) and CD3+CD4+CD25+ (p < 0.0001) and a significant decrease in CD3+CD4+CD25-FOXP3+ (p < 0.05). SNPs in the TNF-α (rs361525) gene presented a difference in the genotype distribution between the groups (p = 0.002). The genotype distribution of TNF-α (rs361525) was also positively correlated with the DNA damage of the exposed group (r = 0.19; p = 0.01), demonstrating a higher risk of DNA damage in the farmworkers presenting the A mutated allele. Our findings demonstrate that pesticides can exert various deleterious effects on human health by damaging the DNA as well as by influencing the immune system in the case of both direct or indirect exposure and these issues are associated to age, gender, intoxication and the nonuse of PPE." @default.
• W3080508052 created "2020-09-01" @default.
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• W3080508052 date "2021-02-01" @default.
• W3080508052 modified "2023-10-09" @default.
• W3080508052 title "Multi-biomarker responses to pesticides in an agricultural population from Central Brazil" @default.
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• W3080508052 doi "https://doi.org/10.1016/j.scitotenv.2020.141893" @default.
• W3080508052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7441936" @default.
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• W3080508052 hasPublicationYear "2021" @default.
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