FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080526664> ?p ?o ?g. }

• W3080526664 abstract "Abstract Background Urolithiasis is a worldwide urological problem with significant contribution of genetic factors. Pakistan, which resides within the Afro-Asian stone belt, has a high reported prevalence (12%) of urolithiasis. Osteopontin (SPP1) is a urinary macromolecule with a suggested critical role in modulating renal stone formation, genetic polymorphisms of which may determine individual risk of developing urolithiasis. However, results of previous studies regarding SPP1 polymorphisms and susceptibility to urolithiasis have apparent inconsistencies with no data available for local population. Methods A total of 235 urolithiasis patients and 243 healthy controls, all of Pakistani ancestry, underwent genotyping for six SPP1 genetic polymorphisms in an effort to investigate potential association with urolithiasis using indigenous candidate gene association study design. Further, a comprehensive meta-analysis following a systematic literature search was also done to ascertain an evidence based account of any existent association regarding SPP1 promoter polymorphisms and risk of developing urolithiasis. Results Three SPP1 promoter polymorphisms, rs2853744:G > T, rs11730582:T > C and rs11439060:delG>G, were found to be significantly associated with risk of urolithiasis in indigenous genetic association study (OR = 3.14; p = 0.006, OR = 1.78; p = 0.006 and OR = 1.60; p = 0.012, respectively). We also observed a 1.68-fold positive association of a tri-allelic haplotype of these SPP1 promoter polymorphisms (G-C-dG) with risk of urolithiasis (OR = 1.68; p = 0.0079). However, no association was evident when data were stratified according to gender, age at first presentation, stone recurrence, stone multiplicity, parental consanguinity and family history of urolithiasis. The overall results from meta-analysis, which included 4 studies, suggested a significant association of SPP1 rs2853744:G > T polymorphism with susceptibility of urolithiasis (OR = 1.37; p = 0.004), but not for other SPP1 polymorphic variants analyzed. Conclusions In conclusion, we report significant association of 3 SPP1 polymorphisms with urolithiasis for the first time from South Asia, however, this association persisted only for SPP1 rs2853744:G > T polymorphism after meta-analysis of pooled studies. Further studies with a larger sample size will be required to validate this association and assess any potential usefulness in diagnosis and prognosis of renal stone disease." @default.
• W3080526664 created "2020-09-01" @default.
• W3080526664 creator A5006451534 @default.
• W3080526664 creator A5033055895 @default.
• W3080526664 creator A5043570100 @default.
• W3080526664 creator A5051151439 @default.
• W3080526664 creator A5069946623 @default.
• W3080526664 creator A5082321533 @default.
• W3080526664 creator A5087683934 @default.
• W3080526664 creator A5088171409 @default.
• W3080526664 date "2020-08-25" @default.
• W3080526664 modified "2023-10-16" @default.
• W3080526664 title "Osteopontin promoter polymorphisms and risk of urolithiasis: a candidate gene association and meta-analysis study" @default.
• W3080526664 cites W1491761595 @default.
• W3080526664 cites W1746324461 @default.
• W3080526664 cites W182433476 @default.
• W3080526664 cites W1964435302 @default.
• W3080526664 cites W1968695451 @default.
• W3080526664 cites W1984170705 @default.
• W3080526664 cites W1993462736 @default.
• W3080526664 cites W1995652551 @default.
• W3080526664 cites W1998095820 @default.
• W3080526664 cites W2002038522 @default.
• W3080526664 cites W2005129602 @default.
• W3080526664 cites W2008747832 @default.
• W3080526664 cites W2044410462 @default.
• W3080526664 cites W2045626819 @default.
• W3080526664 cites W2047376085 @default.
• W3080526664 cites W2049422869 @default.
• W3080526664 cites W2057325340 @default.
• W3080526664 cites W2059781533 @default.
• W3080526664 cites W2064767194 @default.
• W3080526664 cites W2072529206 @default.
• W3080526664 cites W2073034320 @default.
• W3080526664 cites W2098097911 @default.
• W3080526664 cites W2139377231 @default.
• W3080526664 cites W2156098321 @default.
• W3080526664 cites W2157823046 @default.
• W3080526664 cites W2157929834 @default.
• W3080526664 cites W2160570558 @default.
• W3080526664 cites W2160859576 @default.
• W3080526664 cites W2162530578 @default.
• W3080526664 cites W2263715678 @default.
• W3080526664 cites W2360123755 @default.
• W3080526664 cites W246286872 @default.
• W3080526664 cites W2494709610 @default.
• W3080526664 cites W2560440401 @default.
• W3080526664 cites W2588771666 @default.
• W3080526664 cites W2902941584 @default.
• W3080526664 cites W2914195783 @default.
• W3080526664 cites W2939814733 @default.
• W3080526664 cites W2973092429 @default.
• W3080526664 cites W4294215472 @default.
• W3080526664 doi "https://doi.org/10.1186/s12881-020-01101-2" @default.
• W3080526664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7446165" @default.
• W3080526664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32842990" @default.
• W3080526664 hasPublicationYear "2020" @default.
• W3080526664 type Work @default.
• W3080526664 sameAs 3080526664 @default.
• W3080526664 citedByCount "5" @default.
• W3080526664 countsByYear W30805266642021 @default.
• W3080526664 countsByYear W30805266642022 @default.
• W3080526664 countsByYear W30805266642023 @default.
• W3080526664 crossrefType "journal-article" @default.
• W3080526664 hasAuthorship W3080526664A5006451534 @default.
• W3080526664 hasAuthorship W3080526664A5033055895 @default.
• W3080526664 hasAuthorship W3080526664A5043570100 @default.
• W3080526664 hasAuthorship W3080526664A5051151439 @default.
• W3080526664 hasAuthorship W3080526664A5069946623 @default.
• W3080526664 hasAuthorship W3080526664A5082321533 @default.
• W3080526664 hasAuthorship W3080526664A5087683934 @default.
• W3080526664 hasAuthorship W3080526664A5088171409 @default.
• W3080526664 hasBestOaLocation W30805266641 @default.
• W3080526664 hasConcept C104317684 @default.
• W3080526664 hasConcept C126322002 @default.
• W3080526664 hasConcept C135763542 @default.
• W3080526664 hasConcept C153209595 @default.
• W3080526664 hasConcept C180754005 @default.
• W3080526664 hasConcept C186413461 @default.
• W3080526664 hasConcept C197754878 @default.
• W3080526664 hasConcept C2780804394 @default.
• W3080526664 hasConcept C31467283 @default.
• W3080526664 hasConcept C54355233 @default.
• W3080526664 hasConcept C60644358 @default.
• W3080526664 hasConcept C69991583 @default.
• W3080526664 hasConcept C71924100 @default.
• W3080526664 hasConcept C86803240 @default.
• W3080526664 hasConcept C95190672 @default.
• W3080526664 hasConceptScore W3080526664C104317684 @default.
• W3080526664 hasConceptScore W3080526664C126322002 @default.
• W3080526664 hasConceptScore W3080526664C135763542 @default.
• W3080526664 hasConceptScore W3080526664C153209595 @default.
• W3080526664 hasConceptScore W3080526664C180754005 @default.
• W3080526664 hasConceptScore W3080526664C186413461 @default.
• W3080526664 hasConceptScore W3080526664C197754878 @default.
• W3080526664 hasConceptScore W3080526664C2780804394 @default.
• W3080526664 hasConceptScore W3080526664C31467283 @default.
• W3080526664 hasConceptScore W3080526664C54355233 @default.
• W3080526664 hasConceptScore W3080526664C60644358 @default.
• W3080526664 hasConceptScore W3080526664C69991583 @default.

• next