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- W3080544776 abstract "Significance Since fever is frequently a response to infection, immune responses likely occur commonly at fever temperatures. Are fever temperatures detected by immune cells, what molecular pathways are involved in this sensing, and what are the functional consequences? Our data show that CD4 T lymphocytes detect moderate fever temperature. A TRPV channel-mediated pathway involving Notch activation leads to a Th2 skewing of the effector T cell response. However, the antigen presenting dendritic cells that stimulate CD4 T cells, in turn, detect fever temperature and overproduce interleukin-12 to counter this Th2 skewing. The evolutionary genesis of these pathways and the functional consequences of this complex regulatory loop in specific infectious circumstances are, thus, likely to be of great interest." @default.
- W3080544776 created "2020-09-01" @default.
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- W3080544776 date "2020-08-24" @default.
- W3080544776 modified "2023-10-16" @default.
- W3080544776 title "Febrile temperature change modulates CD4 T cell differentiation via a TRPV channel-regulated Notch-dependent pathway" @default.
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- W3080544776 doi "https://doi.org/10.1073/pnas.1922683117" @default.
- W3080544776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7486768" @default.
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