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- W3080556671 abstract "Irbesartan, (2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one), is a member of non-peptide angiotensin II receptor antagonists used worldwide in the treatment of hypertension and diabetic nephropathy in hypertensive patients with type 2 diabetes, elevated serum creatinine, and proteinuria. Irbesartan can be used alone or in combination with other antihypertensive agents (e.g., hydrochlorothiazide). These combination products are indicated for hypertension in patients with uncontrolled hypertension with monotherapy or first line in patients not expected to be well controlled with monotherapy. Irbesartan is also indicated for the treatment of diabetic nephropathy in patients with type 2 diabetes and hypertension, an elevated serum creatinine, and proteinuria. Irbesartan exerts its action mainly via a selective blockade action on AT1 receptors and the consequent reduced pressor effect of angiotensin II. This article discusses, by a critical comprehensive review of the literature on irbesartan in terms of its description, names, formulae, elemental composition, appearance, and therapeutic uses. The article also discusses the methods for preparation of irbesartan, its physical-chemical properties, analytical methods for its determination, pharmacological-toxicological properties, and dosing information." @default.
- W3080556671 created "2020-09-01" @default.
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- W3080556671 date "2021-01-01" @default.
- W3080556671 modified "2023-10-12" @default.
- W3080556671 title "Irbesartan (a comprehensive profile)" @default.
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- W3080556671 cites W1973943566 @default.
- W3080556671 cites W1994861172 @default.
- W3080556671 cites W1996467197 @default.
- W3080556671 cites W1999448323 @default.
- W3080556671 cites W2000942415 @default.
- W3080556671 cites W2005134516 @default.
- W3080556671 cites W2010032613 @default.
- W3080556671 cites W2010533246 @default.
- W3080556671 cites W2014938147 @default.
- W3080556671 cites W2015634686 @default.
- W3080556671 cites W2016430190 @default.
- W3080556671 cites W2020807534 @default.
- W3080556671 cites W2028802755 @default.
- W3080556671 cites W2028849364 @default.
- W3080556671 cites W2036748366 @default.
- W3080556671 cites W2038736219 @default.
- W3080556671 cites W2041817883 @default.
- W3080556671 cites W2043567295 @default.
- W3080556671 cites W2044329979 @default.
- W3080556671 cites W2047705444 @default.
- W3080556671 cites W2047774611 @default.
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- W3080556671 cites W2064277880 @default.
- W3080556671 cites W2064590526 @default.
- W3080556671 cites W2068785950 @default.
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- W3080556671 cites W2083639998 @default.
- W3080556671 cites W2085086980 @default.
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- W3080556671 cites W2093144961 @default.
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- W3080556671 cites W2114057645 @default.
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- W3080556671 cites W2329032005 @default.
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- W3080556671 doi "https://doi.org/10.1016/bs.podrm.2020.07.004" @default.
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