FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080574503> ?p ?o ?g. }

• W3080574503 endingPage "1029" @default.
• W3080574503 startingPage "1029" @default.
• W3080574503 abstract "Allergen exposure induces aberrant T helper (Th) 2 immune responses in patients with allergic asthma, but not in sensitized asymptomatic and nonallergic subjects. Interleukin (IL)-35-induced regulatory T (iTr35) cells are a new subset of regulatory T cells with immunoregulatory properties. These cells can significantly suppress Th2 responses in seasonal allergic rhinitis. However, it remains unknown whether iTr35 cells are involved in the immunoregulation of allergic asthmatic individuals after specific allergen exposure.The iTr35 cell frequency in peripheral blood mononuclear cells (PBMCs) was measured in patients with allergic asthma as well as in asymptomatic and healthy subjects. The difference in naïve CD4⁺ T cell conversion to iTr35 cells in vitro during allergen stimulation was also investigated. The effects of iTr35 cells on naïve CD4⁺ T cell differentiation into Th2 cells, CD4⁺CD25- T (Teff) cell proliferation and Th2 cytokine production in vitro were assessed.Significantly reduced iTr35 cell frequencies and IL-35 expression levels were found in asthmatic patients with Derp1 allergy compared with asymptomatic and healthy subjects. Moreover, the circulating iTr35 cell proportion and IL-35 expression level in asthmatic patients gradually decreased with disease severity. Patients with allergic asthma had reduced transformation of naïve CD4⁺ T cells into iTr35 cells and IL-35 production after allergen exposure compared with asymptomatic and healthy subjects. Most importantly, iTr35 cells inhibited allergen-driven differentiation of naïve CD4⁺ T cells into Th2 cells, Teff cell proliferation and Th2 cytokine production in an IL-35-dependent manner.The results of our study suggest that iTr35 cells may play an important role in preventing Th2 responses to allergens by secreting IL-35 and that iTr35 cells may be a potential new immune regulator of allergic asthma." @default.
• W3080574503 created "2020-09-01" @default.
• W3080574503 creator A5010008442 @default.
• W3080574503 creator A5030662928 @default.
• W3080574503 creator A5032329074 @default.
• W3080574503 creator A5045852733 @default.
• W3080574503 date "2020-01-01" @default.
• W3080574503 modified "2023-10-13" @default.
• W3080574503 title "Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma" @default.
• W3080574503 cites W1830969647 @default.
• W3080574503 cites W1850727658 @default.
• W3080574503 cites W1927370990 @default.
• W3080574503 cites W1942586809 @default.
• W3080574503 cites W1963511922 @default.
• W3080574503 cites W1966922635 @default.
• W3080574503 cites W1973246406 @default.
• W3080574503 cites W1992553838 @default.
• W3080574503 cites W2009987865 @default.
• W3080574503 cites W2017963033 @default.
• W3080574503 cites W2029117531 @default.
• W3080574503 cites W2048708042 @default.
• W3080574503 cites W2050237494 @default.
• W3080574503 cites W2064228332 @default.
• W3080574503 cites W2067356055 @default.
• W3080574503 cites W2075951089 @default.
• W3080574503 cites W2084708073 @default.
• W3080574503 cites W2086849947 @default.
• W3080574503 cites W2089197792 @default.
• W3080574503 cites W2100474263 @default.
• W3080574503 cites W2101102426 @default.
• W3080574503 cites W2107277218 @default.
• W3080574503 cites W2108499873 @default.
• W3080574503 cites W2121221609 @default.
• W3080574503 cites W2151589124 @default.
• W3080574503 cites W2153389047 @default.
• W3080574503 cites W2161826873 @default.
• W3080574503 cites W2192080449 @default.
• W3080574503 cites W2328125480 @default.
• W3080574503 cites W234350118 @default.
• W3080574503 cites W2404430975 @default.
• W3080574503 cites W2469305259 @default.
• W3080574503 cites W2523676051 @default.
• W3080574503 cites W2620482670 @default.
• W3080574503 cites W2883695111 @default.
• W3080574503 cites W2895893228 @default.
• W3080574503 cites W2911931405 @default.
• W3080574503 doi "https://doi.org/10.4168/aair.2020.12.6.1029" @default.
• W3080574503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7492513" @default.
• W3080574503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32935493" @default.
• W3080574503 hasPublicationYear "2020" @default.
• W3080574503 type Work @default.
• W3080574503 sameAs 3080574503 @default.
• W3080574503 citedByCount "9" @default.
• W3080574503 countsByYear W30805745032021 @default.
• W3080574503 countsByYear W30805745032022 @default.
• W3080574503 countsByYear W30805745032023 @default.
• W3080574503 crossrefType "journal-article" @default.
• W3080574503 hasAuthorship W3080574503A5010008442 @default.
• W3080574503 hasAuthorship W3080574503A5030662928 @default.
• W3080574503 hasAuthorship W3080574503A5032329074 @default.
• W3080574503 hasAuthorship W3080574503A5045852733 @default.
• W3080574503 hasBestOaLocation W30805745031 @default.
• W3080574503 hasConcept C126322002 @default.
• W3080574503 hasConcept C137061746 @default.
• W3080574503 hasConcept C181901479 @default.
• W3080574503 hasConcept C191732599 @default.
• W3080574503 hasConcept C202751555 @default.
• W3080574503 hasConcept C203014093 @default.
• W3080574503 hasConcept C207480886 @default.
• W3080574503 hasConcept C2776042228 @default.
• W3080574503 hasConcept C2776090121 @default.
• W3080574503 hasConcept C2777910003 @default.
• W3080574503 hasConcept C2778690821 @default.
• W3080574503 hasConcept C2779675166 @default.
• W3080574503 hasConcept C2780510475 @default.
• W3080574503 hasConcept C55493867 @default.
• W3080574503 hasConcept C71924100 @default.
• W3080574503 hasConcept C74172505 @default.
• W3080574503 hasConcept C79484868 @default.
• W3080574503 hasConcept C86803240 @default.
• W3080574503 hasConcept C8891405 @default.
• W3080574503 hasConceptScore W3080574503C126322002 @default.
• W3080574503 hasConceptScore W3080574503C137061746 @default.
• W3080574503 hasConceptScore W3080574503C181901479 @default.
• W3080574503 hasConceptScore W3080574503C191732599 @default.
• W3080574503 hasConceptScore W3080574503C202751555 @default.
• W3080574503 hasConceptScore W3080574503C203014093 @default.
• W3080574503 hasConceptScore W3080574503C207480886 @default.
• W3080574503 hasConceptScore W3080574503C2776042228 @default.
• W3080574503 hasConceptScore W3080574503C2776090121 @default.
• W3080574503 hasConceptScore W3080574503C2777910003 @default.
• W3080574503 hasConceptScore W3080574503C2778690821 @default.
• W3080574503 hasConceptScore W3080574503C2779675166 @default.
• W3080574503 hasConceptScore W3080574503C2780510475 @default.
• W3080574503 hasConceptScore W3080574503C55493867 @default.
• W3080574503 hasConceptScore W3080574503C71924100 @default.
• W3080574503 hasConceptScore W3080574503C74172505 @default.
• W3080574503 hasConceptScore W3080574503C79484868 @default.

• next