Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080592806> ?p ?o ?g. }
- W3080592806 endingPage "21569" @default.
- W3080592806 startingPage "21561" @default.
- W3080592806 abstract "Gynostemma pentaphyllum (the immortal herb) has been an important component of Chinese Traditional Medicine for millennia. Recent clinical studies have revealed that the plant exhibits numerous beneficial biological activities, making it of interest to the pharmaceutical industry. An extract of the herb contains over 200 individual secondary metabolites including flavonol glycosides and dammarane saponins. To focus attention on the compounds most likely to be responsible for the biological activities, this study predicts the potential oral bioavailability of nine dammarane saponins and five flavonol glycosides from G. pentaphyllum using the Caco-2 cell monolayer permeability model. Two flavonoids, 8 and 9, and four saponins, 10, 11, 12, and 14, exhibited high permeability across the monolayers. The results indicated that a higher degree of glycosylation-facilitated permeability, suggestive of active transport. This study demonstrates the utility of the Caco-2 permeability assay as a method of identifying possible bioavailable compounds from medicinal herbal extracts." @default.
- W3080592806 created "2020-09-01" @default.
- W3080592806 creator A5001692922 @default.
- W3080592806 creator A5060109043 @default.
- W3080592806 creator A5066801642 @default.
- W3080592806 creator A5078115464 @default.
- W3080592806 creator A5080089266 @default.
- W3080592806 date "2020-08-20" @default.
- W3080592806 modified "2023-10-12" @default.
- W3080592806 title "Caco-2 Cell Permeability of Flavonoids and Saponins from <i>Gynostemma pentaphyllum</i>: the Immortal Herb" @default.
- W3080592806 cites W144342570 @default.
- W3080592806 cites W1566211379 @default.
- W3080592806 cites W1755208670 @default.
- W3080592806 cites W1831870119 @default.
- W3080592806 cites W1970854190 @default.
- W3080592806 cites W1971624284 @default.
- W3080592806 cites W1977120233 @default.
- W3080592806 cites W1979196526 @default.
- W3080592806 cites W1988319187 @default.
- W3080592806 cites W1990236573 @default.
- W3080592806 cites W1994150262 @default.
- W3080592806 cites W2012235643 @default.
- W3080592806 cites W2016435923 @default.
- W3080592806 cites W2030247333 @default.
- W3080592806 cites W2040296084 @default.
- W3080592806 cites W2054471525 @default.
- W3080592806 cites W2060192193 @default.
- W3080592806 cites W2069978879 @default.
- W3080592806 cites W2082647909 @default.
- W3080592806 cites W2084125416 @default.
- W3080592806 cites W2105943444 @default.
- W3080592806 cites W2108255861 @default.
- W3080592806 cites W2108662565 @default.
- W3080592806 cites W2114006639 @default.
- W3080592806 cites W2120426354 @default.
- W3080592806 cites W2133194575 @default.
- W3080592806 cites W2139552251 @default.
- W3080592806 cites W2150106457 @default.
- W3080592806 cites W2171842084 @default.
- W3080592806 cites W2334640164 @default.
- W3080592806 cites W2410681056 @default.
- W3080592806 cites W2420441891 @default.
- W3080592806 cites W2467378800 @default.
- W3080592806 cites W2514393632 @default.
- W3080592806 cites W2769117226 @default.
- W3080592806 cites W2769567459 @default.
- W3080592806 cites W2794003199 @default.
- W3080592806 cites W4244643302 @default.
- W3080592806 cites W63256203 @default.
- W3080592806 doi "https://doi.org/10.1021/acsomega.0c02180" @default.
- W3080592806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7469392" @default.
- W3080592806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32905390" @default.
- W3080592806 hasPublicationYear "2020" @default.
- W3080592806 type Work @default.
- W3080592806 sameAs 3080592806 @default.
- W3080592806 citedByCount "14" @default.
- W3080592806 countsByYear W30805928062021 @default.
- W3080592806 countsByYear W30805928062022 @default.
- W3080592806 countsByYear W30805928062023 @default.
- W3080592806 crossrefType "journal-article" @default.
- W3080592806 hasAuthorship W3080592806A5001692922 @default.
- W3080592806 hasAuthorship W3080592806A5060109043 @default.
- W3080592806 hasAuthorship W3080592806A5066801642 @default.
- W3080592806 hasAuthorship W3080592806A5078115464 @default.
- W3080592806 hasAuthorship W3080592806A5080089266 @default.
- W3080592806 hasBestOaLocation W30805928061 @default.
- W3080592806 hasConcept C142724271 @default.
- W3080592806 hasConcept C181389837 @default.
- W3080592806 hasConcept C185592680 @default.
- W3080592806 hasConcept C194671627 @default.
- W3080592806 hasConcept C204787440 @default.
- W3080592806 hasConcept C2778564307 @default.
- W3080592806 hasConcept C2778713507 @default.
- W3080592806 hasConcept C2779754220 @default.
- W3080592806 hasConcept C2779824472 @default.
- W3080592806 hasConcept C2780527577 @default.
- W3080592806 hasConcept C2991655182 @default.
- W3080592806 hasConcept C43617362 @default.
- W3080592806 hasConcept C4725764 @default.
- W3080592806 hasConcept C556039675 @default.
- W3080592806 hasConcept C71240020 @default.
- W3080592806 hasConcept C71924100 @default.
- W3080592806 hasConcept C86803240 @default.
- W3080592806 hasConcept C98274493 @default.
- W3080592806 hasConceptScore W3080592806C142724271 @default.
- W3080592806 hasConceptScore W3080592806C181389837 @default.
- W3080592806 hasConceptScore W3080592806C185592680 @default.
- W3080592806 hasConceptScore W3080592806C194671627 @default.
- W3080592806 hasConceptScore W3080592806C204787440 @default.
- W3080592806 hasConceptScore W3080592806C2778564307 @default.
- W3080592806 hasConceptScore W3080592806C2778713507 @default.
- W3080592806 hasConceptScore W3080592806C2779754220 @default.
- W3080592806 hasConceptScore W3080592806C2779824472 @default.
- W3080592806 hasConceptScore W3080592806C2780527577 @default.
- W3080592806 hasConceptScore W3080592806C2991655182 @default.
- W3080592806 hasConceptScore W3080592806C43617362 @default.
- W3080592806 hasConceptScore W3080592806C4725764 @default.
- W3080592806 hasConceptScore W3080592806C556039675 @default.