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- W3080593203 abstract "The decrease of corneal stiffness is the key factor leading to keratoconus, and the corneal collagen fiber stiffness and fiber dispersion are closely related to the corneal biomechanical properties. In this paper, a finite element model of human cornea based on corneal microstructure, namely collagen fiber, was established before and after laser assisted in situ keratomileusis (LASIK). By simulating the Corvis ST process and comparing with the actual clinical results, the hyperelastic constitutive parameters and corneal collagen fiber stiffness modulus of the corneal material were determined before and after refractive surgery. After LASIK, the corneal collagen fiber stiffness modulus increased significantly, and was highly correlated with central corneal thickness (CCT). The predictive relationship between the corneal collagen fiber stiffness modulus and the corresponding CCT before and after surgery was: k1 before = exp(9.14 - 0.009CCT before), k1 after = exp(8.82 - 0.008CCT after). According to the results of this study, the central corneal thickness of the patient can be used to estimate the preoperative and postoperative collagen fiber stiffness modulus, and then a personalized corneal model that is more consistent with the actual situation of the patient can be established, providing a theoretical reference for more accurately predicting the safe surgical cutting amount of the cornea.角膜的刚度降低是导致圆锥角膜的关键因素，角膜中胶原纤维刚度和纤维分散程度与角膜生物力学性能密切相关。本文通过建立基于角膜微结构即考虑胶原纤维的准分子激光原位角膜磨镶术（LASIK）术前和术后人眼角膜有限元模型，模拟了可视化角膜生物力学分析仪的检测过程，并与临床实际检测结果对比，确定屈光手术前后人眼角膜材料的超弹性本构参数及角膜胶原纤维刚度模量。研究发现 LASIK 术后，角膜胶原纤维刚度模量较术前明显增大，并与中央角膜厚度（CCT）高度相关；术前术后角膜胶原纤维刚度模量与对应中央角膜厚度的预测关系分别为： k1 术前 = exp（9.14 − 0.009CCT 术前）， k1 术后 = exp（8.82 − 0.008CCT 术后）。根据本文的研究结果，可由患者的中央角膜厚度值估算其术前术后胶原纤维刚度模量，进而建立与患者实际情况更相符的个性化角膜模型，为更准确地预测角膜安全手术切削量提供理论参考。." @default.
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- W3080593203 date "2020-08-25" @default.
- W3080593203 modified "2023-10-17" @default.
- W3080593203 title "[Finite element analysis of determining corneal biomechanical properties in vivo based on Corvis ST]." @default.
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- W3080593203 doi "https://doi.org/10.7507/1001-5515.201911081" @default.
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