Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080595870> ?p ?o ?g. }
- W3080595870 endingPage "2414" @default.
- W3080595870 startingPage "2414" @default.
- W3080595870 abstract "Ovarian tumor is the gynecological cancer associated with the highest mortality. Most diseases are diagnosed at an advanced stage, which impairs the chances of prolonged complete remission. The standard front-line treatment of advanced stages combines surgery in an expert center with platinum-based chemotherapy. Most patients experience a relapse in the years following the initial treatment. During the last decade, anti-angiogenic agents used in the maintenance setting improved progression free survival (PFS) over chemotherapy alone. More recently, PARP inhibitors demonstrated substantial efficacy, mainly in patients with germinal or somatic BRCA mutations or other homologous recombination deficiencies (HRD), all involved in double strand DNA Damage Repair (DDR). Other therapeutic paradigms are currently being explored, including combinations of immune-checkpoints inhibitors, chemotherapy, bevacizumab and PARP inhibitors. In addition to these clinical advances, molecular characterization of the tumors and their correlations with drugs efficacy are needed to better understand which patient will benefit the most from the various treatments available to date." @default.
- W3080595870 created "2020-09-01" @default.
- W3080595870 creator A5001985433 @default.
- W3080595870 creator A5017454296 @default.
- W3080595870 creator A5020342097 @default.
- W3080595870 creator A5031036666 @default.
- W3080595870 creator A5042100249 @default.
- W3080595870 creator A5052834446 @default.
- W3080595870 creator A5073787373 @default.
- W3080595870 creator A5085758096 @default.
- W3080595870 creator A5088879599 @default.
- W3080595870 date "2020-08-25" @default.
- W3080595870 modified "2023-09-30" @default.
- W3080595870 title "Front-Line Maintenance Therapy in Advanced Ovarian Cancer—Current Advances and Perspectives" @default.
- W3080595870 cites W1653750710 @default.
- W3080595870 cites W1781764024 @default.
- W3080595870 cites W1896420201 @default.
- W3080595870 cites W1964736695 @default.
- W3080595870 cites W1965398601 @default.
- W3080595870 cites W1973268287 @default.
- W3080595870 cites W1984431444 @default.
- W3080595870 cites W1985804387 @default.
- W3080595870 cites W1989185017 @default.
- W3080595870 cites W2009007206 @default.
- W3080595870 cites W2073569331 @default.
- W3080595870 cites W2074952360 @default.
- W3080595870 cites W2096235803 @default.
- W3080595870 cites W2099380130 @default.
- W3080595870 cites W2100355345 @default.
- W3080595870 cites W2100419317 @default.
- W3080595870 cites W2102306754 @default.
- W3080595870 cites W2109925286 @default.
- W3080595870 cites W2111437716 @default.
- W3080595870 cites W2113122060 @default.
- W3080595870 cites W2117177285 @default.
- W3080595870 cites W2130941707 @default.
- W3080595870 cites W2135947389 @default.
- W3080595870 cites W2138128030 @default.
- W3080595870 cites W2142874979 @default.
- W3080595870 cites W2142950083 @default.
- W3080595870 cites W2151509048 @default.
- W3080595870 cites W2152242889 @default.
- W3080595870 cites W2156500939 @default.
- W3080595870 cites W2169983032 @default.
- W3080595870 cites W2295085830 @default.
- W3080595870 cites W2325848599 @default.
- W3080595870 cites W2345701447 @default.
- W3080595870 cites W2472306545 @default.
- W3080595870 cites W2539944286 @default.
- W3080595870 cites W2557666746 @default.
- W3080595870 cites W2624683647 @default.
- W3080595870 cites W2751912349 @default.
- W3080595870 cites W2754327139 @default.
- W3080595870 cites W2768401374 @default.
- W3080595870 cites W2783907570 @default.
- W3080595870 cites W2793269924 @default.
- W3080595870 cites W2798183676 @default.
- W3080595870 cites W2801496605 @default.
- W3080595870 cites W2802480234 @default.
- W3080595870 cites W2804717005 @default.
- W3080595870 cites W2889646458 @default.
- W3080595870 cites W2890864206 @default.
- W3080595870 cites W2895036167 @default.
- W3080595870 cites W2896626889 @default.
- W3080595870 cites W2897430921 @default.
- W3080595870 cites W2901506506 @default.
- W3080595870 cites W2935067372 @default.
- W3080595870 cites W2935541805 @default.
- W3080595870 cites W2946983074 @default.
- W3080595870 cites W2947257322 @default.
- W3080595870 cites W2947826965 @default.
- W3080595870 cites W2947993621 @default.
- W3080595870 cites W2951714360 @default.
- W3080595870 cites W2954686273 @default.
- W3080595870 cites W2954976904 @default.
- W3080595870 cites W2961496023 @default.
- W3080595870 cites W2975141952 @default.
- W3080595870 cites W2976139792 @default.
- W3080595870 cites W2979625439 @default.
- W3080595870 cites W2980121911 @default.
- W3080595870 cites W2994977341 @default.
- W3080595870 cites W3014984749 @default.
- W3080595870 cites W3020771563 @default.
- W3080595870 cites W3028894214 @default.
- W3080595870 cites W3030471203 @default.
- W3080595870 cites W3030566019 @default.
- W3080595870 cites W3031903430 @default.
- W3080595870 cites W3035853607 @default.
- W3080595870 doi "https://doi.org/10.3390/cancers12092414" @default.
- W3080595870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7564452" @default.
- W3080595870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32854393" @default.
- W3080595870 hasPublicationYear "2020" @default.
- W3080595870 type Work @default.
- W3080595870 sameAs 3080595870 @default.
- W3080595870 citedByCount "10" @default.
- W3080595870 countsByYear W30805958702021 @default.
- W3080595870 countsByYear W30805958702022 @default.
- W3080595870 countsByYear W30805958702023 @default.