FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080615034> ?p ?o ?g. }

• W3080615034 endingPage "639" @default.
• W3080615034 startingPage "630" @default.
• W3080615034 abstract "Hepatic dysfunction frequently occurs after trauma-hemorrhage, resulting in severe pathophysiological responses that include leukocyte shifting and self-mediated mechanisms of cells, such as autophagy and apoptosis. This in vivo study aimed to characterize mitochondrial morphology, leukocyte reaction, and the processes of autophagy and apoptosis after polytrauma hemorrhage (TH) in a long-term, large animal model.Liver tissue was taken from a porcine TH model (hemorrhagic shock, blunt chest trauma, tibia fracture, and liver laceration) with an intensive care unit follow-up of 72 h. The ultrastructural changes of the liver tissue after TH were evaluated by transmission electron microscopy. The leukocyte phenotypes and autophagy and apoptosis pathways were elucidated by immunohistofluorescence, Western blot, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL).In addition to post-traumatic changes in the mitochondrial morphology, the biomarkers of anti-inflammatory macrophages (CD163) and reparative monocytes (CD11R3 and CD16) were upregulated, while the inducible nitric oxide synthase was downregulated after TH. Furthermore, the autophagy-related protein expressions of LC3 and Beclin-1 were upregulated, whereas the protein expression of P62 was downregulated after TH. Costaining showed that the macrophages were LC3 (or Beclin-1) positive and that CD163 was copositive and upregulated. Apoptosis biomarkers (cleaved-caspase-3/caspase-3 and Bcl-2) increased after TH, which is in line with TUNEL results.In conclusion, the observed findings indicate that mitochondrial dysfunction might be one trigger of hepatic autophagy and apoptosis after TH. These processes occur together with the activation of anti-inflammatory leukocytes in liver tissue. Further studies are needed to elucidate the potential therapeutic effects of inhibiting mitochondrial swelling during autophagy or apoptosis." @default.
• W3080615034 created "2020-09-01" @default.
• W3080615034 creator A5003702712 @default.
• W3080615034 creator A5005347897 @default.
• W3080615034 creator A5014749662 @default.
• W3080615034 creator A5017809307 @default.
• W3080615034 creator A5023077253 @default.
• W3080615034 creator A5029639523 @default.
• W3080615034 creator A5031599245 @default.
• W3080615034 creator A5043853769 @default.
• W3080615034 creator A5046972210 @default.
• W3080615034 creator A5047884763 @default.
• W3080615034 creator A5073589118 @default.
• W3080615034 creator A5078137307 @default.
• W3080615034 creator A5080740572 @default.
• W3080615034 date "2020-08-20" @default.
• W3080615034 modified "2023-10-17" @default.
• W3080615034 title "Trauma-Hemorrhage Stimulates Immune Defense, Mitochondrial Dysfunction, Autophagy, and Apoptosis in Pig Liver at 72 h" @default.
• W3080615034 cites W1169647102 @default.
• W3080615034 cites W1604336286 @default.
• W3080615034 cites W1854470074 @default.
• W3080615034 cites W1917838292 @default.
• W3080615034 cites W1976391651 @default.
• W3080615034 cites W1977841275 @default.
• W3080615034 cites W1991692801 @default.
• W3080615034 cites W2001675597 @default.
• W3080615034 cites W2013606469 @default.
• W3080615034 cites W2026578487 @default.
• W3080615034 cites W2028536701 @default.
• W3080615034 cites W2029401533 @default.
• W3080615034 cites W2034132952 @default.
• W3080615034 cites W2037814856 @default.
• W3080615034 cites W2039190163 @default.
• W3080615034 cites W2042962853 @default.
• W3080615034 cites W2052649390 @default.
• W3080615034 cites W2063842938 @default.
• W3080615034 cites W2089573422 @default.
• W3080615034 cites W2094848986 @default.
• W3080615034 cites W2111754392 @default.
• W3080615034 cites W2135008092 @default.
• W3080615034 cites W2135154985 @default.
• W3080615034 cites W2135647797 @default.
• W3080615034 cites W2138915349 @default.
• W3080615034 cites W2155929266 @default.
• W3080615034 cites W2157096314 @default.
• W3080615034 cites W2162054390 @default.
• W3080615034 cites W2402677148 @default.
• W3080615034 cites W2418171330 @default.
• W3080615034 cites W2514647787 @default.
• W3080615034 cites W2528440934 @default.
• W3080615034 cites W2567194193 @default.
• W3080615034 cites W2580555388 @default.
• W3080615034 cites W2758797028 @default.
• W3080615034 cites W2762127310 @default.
• W3080615034 cites W2782443304 @default.
• W3080615034 cites W2939103462 @default.
• W3080615034 cites W2944644737 @default.
• W3080615034 cites W2948231834 @default.
• W3080615034 cites W305471496 @default.
• W3080615034 doi "https://doi.org/10.1097/shk.0000000000001556" @default.
• W3080615034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32826806" @default.
• W3080615034 hasPublicationYear "2020" @default.
• W3080615034 type Work @default.
• W3080615034 sameAs 3080615034 @default.
• W3080615034 citedByCount "5" @default.
• W3080615034 countsByYear W30806150342021 @default.
• W3080615034 countsByYear W30806150342022 @default.
• W3080615034 countsByYear W30806150342023 @default.
• W3080615034 crossrefType "journal-article" @default.
• W3080615034 hasAuthorship W3080615034A5003702712 @default.
• W3080615034 hasAuthorship W3080615034A5005347897 @default.
• W3080615034 hasAuthorship W3080615034A5014749662 @default.
• W3080615034 hasAuthorship W3080615034A5017809307 @default.
• W3080615034 hasAuthorship W3080615034A5023077253 @default.
• W3080615034 hasAuthorship W3080615034A5029639523 @default.
• W3080615034 hasAuthorship W3080615034A5031599245 @default.
• W3080615034 hasAuthorship W3080615034A5043853769 @default.
• W3080615034 hasAuthorship W3080615034A5046972210 @default.
• W3080615034 hasAuthorship W3080615034A5047884763 @default.
• W3080615034 hasAuthorship W3080615034A5073589118 @default.
• W3080615034 hasAuthorship W3080615034A5078137307 @default.
• W3080615034 hasAuthorship W3080615034A5080740572 @default.
• W3080615034 hasConcept C104317684 @default.
• W3080615034 hasConcept C127561419 @default.
• W3080615034 hasConcept C134018914 @default.
• W3080615034 hasConcept C142724271 @default.
• W3080615034 hasConcept C154113507 @default.
• W3080615034 hasConcept C190283241 @default.
• W3080615034 hasConcept C196795494 @default.
• W3080615034 hasConcept C203014093 @default.
• W3080615034 hasConcept C203522944 @default.
• W3080615034 hasConcept C2776637226 @default.
• W3080615034 hasConcept C55493867 @default.
• W3080615034 hasConcept C71924100 @default.
• W3080615034 hasConcept C86803240 @default.
• W3080615034 hasConcept C95444343 @default.
• W3080615034 hasConceptScore W3080615034C104317684 @default.
• W3080615034 hasConceptScore W3080615034C127561419 @default.

• next