Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080678850> ?p ?o ?g. }
- W3080678850 endingPage "470" @default.
- W3080678850 startingPage "470" @default.
- W3080678850 abstract "Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.8 billion. C. difficile infection (CDI) arises from bacteria colonizing the large intestine and releasing two toxins, toxin A (TcdA) and toxin B (TcdB). Generating humoral immunity against C. difficile’s toxins provides protection against primary infection and recurrence. Thus, a vaccine may offer the best opportunity for sustained, long-term protection. We developed a novel single-cycle adenovirus (SC-Ad) vaccine against C. difficile expressing the receptor-binding domains from TcdA and TcdB. The single immunization of mice generated sustained toxin-binding antibody responses and protected them from lethal toxin challenge for up to 38 weeks. Immunized Syrian hamsters produced significant toxin-neutralizing antibodies that increased over 36 weeks. Single intramuscular immunization provided complete protection against lethal BI/NAP1/027 spore challenge 45 weeks later. These data suggest that this replicating vaccine may prove useful against CDI in humans." @default.
- W3080678850 created "2020-09-01" @default.
- W3080678850 creator A5003959361 @default.
- W3080678850 creator A5030139194 @default.
- W3080678850 creator A5055546724 @default.
- W3080678850 creator A5064370193 @default.
- W3080678850 creator A5073092010 @default.
- W3080678850 creator A5073719192 @default.
- W3080678850 creator A5074307320 @default.
- W3080678850 creator A5074550957 @default.
- W3080678850 creator A5080544265 @default.
- W3080678850 date "2020-08-22" @default.
- W3080678850 modified "2023-09-27" @default.
- W3080678850 title "A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile" @default.
- W3080678850 cites W1557780170 @default.
- W3080678850 cites W1922367055 @default.
- W3080678850 cites W1943657509 @default.
- W3080678850 cites W1946699898 @default.
- W3080678850 cites W1967079794 @default.
- W3080678850 cites W1984159364 @default.
- W3080678850 cites W1997459605 @default.
- W3080678850 cites W2007156807 @default.
- W3080678850 cites W2012840701 @default.
- W3080678850 cites W2026991426 @default.
- W3080678850 cites W2042360223 @default.
- W3080678850 cites W2051113797 @default.
- W3080678850 cites W2054258731 @default.
- W3080678850 cites W2064500738 @default.
- W3080678850 cites W2069542935 @default.
- W3080678850 cites W2071054182 @default.
- W3080678850 cites W2082589767 @default.
- W3080678850 cites W2097297514 @default.
- W3080678850 cites W2105720615 @default.
- W3080678850 cites W2105809563 @default.
- W3080678850 cites W2108659548 @default.
- W3080678850 cites W2108975442 @default.
- W3080678850 cites W2112157204 @default.
- W3080678850 cites W2112796153 @default.
- W3080678850 cites W2118125186 @default.
- W3080678850 cites W2127067932 @default.
- W3080678850 cites W2132817733 @default.
- W3080678850 cites W2135959117 @default.
- W3080678850 cites W2140926423 @default.
- W3080678850 cites W2145869286 @default.
- W3080678850 cites W2146108709 @default.
- W3080678850 cites W2146134572 @default.
- W3080678850 cites W2150709141 @default.
- W3080678850 cites W2151646027 @default.
- W3080678850 cites W2152424167 @default.
- W3080678850 cites W2158871837 @default.
- W3080678850 cites W2208337377 @default.
- W3080678850 cites W2218118400 @default.
- W3080678850 cites W2302234533 @default.
- W3080678850 cites W2333285099 @default.
- W3080678850 cites W2341427843 @default.
- W3080678850 cites W2466189768 @default.
- W3080678850 cites W2547782163 @default.
- W3080678850 cites W2558028312 @default.
- W3080678850 cites W2582069104 @default.
- W3080678850 cites W2589899394 @default.
- W3080678850 cites W2603627669 @default.
- W3080678850 cites W2753354586 @default.
- W3080678850 cites W2776175908 @default.
- W3080678850 cites W2791326569 @default.
- W3080678850 cites W2810859251 @default.
- W3080678850 cites W2883530879 @default.
- W3080678850 cites W2886009301 @default.
- W3080678850 cites W2905444998 @default.
- W3080678850 cites W2919475840 @default.
- W3080678850 cites W2947470486 @default.
- W3080678850 cites W398166368 @default.
- W3080678850 doi "https://doi.org/10.3390/vaccines8030470" @default.
- W3080678850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7564163" @default.
- W3080678850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32842679" @default.
- W3080678850 hasPublicationYear "2020" @default.
- W3080678850 type Work @default.
- W3080678850 sameAs 3080678850 @default.
- W3080678850 citedByCount "4" @default.
- W3080678850 countsByYear W30806788502021 @default.
- W3080678850 countsByYear W30806788502022 @default.
- W3080678850 countsByYear W30806788502023 @default.
- W3080678850 crossrefType "journal-article" @default.
- W3080678850 hasAuthorship W3080678850A5003959361 @default.
- W3080678850 hasAuthorship W3080678850A5030139194 @default.
- W3080678850 hasAuthorship W3080678850A5055546724 @default.
- W3080678850 hasAuthorship W3080678850A5064370193 @default.
- W3080678850 hasAuthorship W3080678850A5073092010 @default.
- W3080678850 hasAuthorship W3080678850A5073719192 @default.
- W3080678850 hasAuthorship W3080678850A5074307320 @default.
- W3080678850 hasAuthorship W3080678850A5074550957 @default.
- W3080678850 hasAuthorship W3080678850A5080544265 @default.
- W3080678850 hasBestOaLocation W30806788501 @default.
- W3080678850 hasConcept C134193097 @default.
- W3080678850 hasConcept C14086860 @default.
- W3080678850 hasConcept C159047783 @default.
- W3080678850 hasConcept C159654299 @default.
- W3080678850 hasConcept C203014093 @default.
- W3080678850 hasConcept C2777367657 @default.