FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080692076> ?p ?o ?g. }

• W3080692076 abstract "Abstract Background Axonal degeneration (AxD) is a pathological hallmark of many neurodegenerative diseases. Deciphering the morphological patterns of AxD will help to understand the underlying mechanisms and to develop effective therapeutic interventions. Here, we evaluated the progression of AxD in cortical neurons using a novel microfluidic device in combination with a deep learning tool, the EntireAxon, that we developed for the enhanced-throughput analysis of AxD on microscopic images. Results The EntireAxon convolutional neural network sensitively and specifically segmented the features of AxD, including axons, axonal swellings, and axonal fragments, and its performance exceeded that of human expert raters. In an in vitro model of AxD in hemorrhagic stroke induced by the hemolysis product hemin, we detected the concentration- and time-dependent degeneration of axons leading to a decrease in axon area, while the axonal swelling and axonal fragment area increased. Time course analysis revealed that axonal swellings preceded axon fragmentation, suggesting that swellings may be reliable predictors of AxD. Using a recurrent neural network, we further identified four morphological patterns of AxD (granular, retraction, swelling, and transport degeneration) in cortical axons subjected to hemin. Conclusions These findings indicate a morphological heterogeneity of AxD under pathophysiologic conditions. The combination of the microfluidic device with the EntireAxon deep learning tool enable the systematic analysis of AxD but also unravel a so far unknown intricacy in which AxD can occur in a disease context." @default.
• W3080692076 created "2020-09-01" @default.
• W3080692076 creator A5002875288 @default.
• W3080692076 creator A5017550767 @default.
• W3080692076 creator A5018566743 @default.
• W3080692076 creator A5019104454 @default.
• W3080692076 creator A5028691724 @default.
• W3080692076 creator A5033925768 @default.
• W3080692076 creator A5036870845 @default.
• W3080692076 creator A5039029813 @default.
• W3080692076 creator A5051881482 @default.
• W3080692076 creator A5053815994 @default.
• W3080692076 creator A5054891474 @default.
• W3080692076 creator A5058755705 @default.
• W3080692076 creator A5070442834 @default.
• W3080692076 creator A5078305808 @default.
• W3080692076 creator A5080121390 @default.
• W3080692076 date "2020-08-27" @default.
• W3080692076 modified "2023-09-27" @default.
• W3080692076 title "Deep learning to decipher the progression and morphology of axonal degeneration" @default.
• W3080692076 cites W1677823206 @default.
• W3080692076 cites W1964819235 @default.
• W3080692076 cites W1974282807 @default.
• W3080692076 cites W1974604937 @default.
• W3080692076 cites W1975518016 @default.
• W3080692076 cites W1979190686 @default.
• W3080692076 cites W1984096229 @default.
• W3080692076 cites W1991858809 @default.
• W3080692076 cites W2002433576 @default.
• W3080692076 cites W2036141603 @default.
• W3080692076 cites W2042991032 @default.
• W3080692076 cites W2045855955 @default.
• W3080692076 cites W2092126505 @default.
• W3080692076 cites W2094008621 @default.
• W3080692076 cites W2094807338 @default.
• W3080692076 cites W2100728233 @default.
• W3080692076 cites W2116838881 @default.
• W3080692076 cites W2119973106 @default.
• W3080692076 cites W2122922916 @default.
• W3080692076 cites W2127882138 @default.
• W3080692076 cites W2131673631 @default.
• W3080692076 cites W2140223118 @default.
• W3080692076 cites W2151103935 @default.
• W3080692076 cites W2165908983 @default.
• W3080692076 cites W2486495263 @default.
• W3080692076 cites W2550807127 @default.
• W3080692076 cites W2593130667 @default.
• W3080692076 cites W2740768704 @default.
• W3080692076 cites W2743809422 @default.
• W3080692076 cites W2762020729 @default.
• W3080692076 cites W2787894218 @default.
• W3080692076 cites W2891595683 @default.
• W3080692076 cites W2903337356 @default.
• W3080692076 cites W2924659304 @default.
• W3080692076 cites W2981144931 @default.
• W3080692076 cites W2984329630 @default.
• W3080692076 cites W3009141398 @default.
• W3080692076 cites W2024280677 @default.
• W3080692076 doi "https://doi.org/10.1101/2020.08.26.269092" @default.
• W3080692076 hasPublicationYear "2020" @default.
• W3080692076 type Work @default.
• W3080692076 sameAs 3080692076 @default.
• W3080692076 citedByCount "0" @default.
• W3080692076 crossrefType "posted-content" @default.
• W3080692076 hasAuthorship W3080692076A5002875288 @default.
• W3080692076 hasAuthorship W3080692076A5017550767 @default.
• W3080692076 hasAuthorship W3080692076A5018566743 @default.
• W3080692076 hasAuthorship W3080692076A5019104454 @default.
• W3080692076 hasAuthorship W3080692076A5028691724 @default.
• W3080692076 hasAuthorship W3080692076A5033925768 @default.
• W3080692076 hasAuthorship W3080692076A5036870845 @default.
• W3080692076 hasAuthorship W3080692076A5039029813 @default.
• W3080692076 hasAuthorship W3080692076A5051881482 @default.
• W3080692076 hasAuthorship W3080692076A5053815994 @default.
• W3080692076 hasAuthorship W3080692076A5054891474 @default.
• W3080692076 hasAuthorship W3080692076A5058755705 @default.
• W3080692076 hasAuthorship W3080692076A5070442834 @default.
• W3080692076 hasAuthorship W3080692076A5078305808 @default.
• W3080692076 hasAuthorship W3080692076A5080121390 @default.
• W3080692076 hasBestOaLocation W30806920761 @default.
• W3080692076 hasConcept C142724271 @default.
• W3080692076 hasConcept C169760540 @default.
• W3080692076 hasConcept C2779354088 @default.
• W3080692076 hasConcept C2779530196 @default.
• W3080692076 hasConcept C2909516373 @default.
• W3080692076 hasConcept C71924100 @default.
• W3080692076 hasConcept C86803240 @default.
• W3080692076 hasConceptScore W3080692076C142724271 @default.
• W3080692076 hasConceptScore W3080692076C169760540 @default.
• W3080692076 hasConceptScore W3080692076C2779354088 @default.
• W3080692076 hasConceptScore W3080692076C2779530196 @default.
• W3080692076 hasConceptScore W3080692076C2909516373 @default.
• W3080692076 hasConceptScore W3080692076C71924100 @default.
• W3080692076 hasConceptScore W3080692076C86803240 @default.
• W3080692076 hasLocation W30806920761 @default.
• W3080692076 hasLocation W30806920762 @default.
• W3080692076 hasOpenAccess W3080692076 @default.
• W3080692076 hasPrimaryLocation W30806920761 @default.
• W3080692076 hasRelatedWork W10966727 @default.
• W3080692076 hasRelatedWork W16412244 @default.

• next