FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080701870> ?p ?o ?g. }

• W3080701870 endingPage "20" @default.
• W3080701870 startingPage "1" @default.
• W3080701870 abstract "Aims . The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. Materials and Methods . Mice were treated with RSV by gastric tube (320 mg/kg/day) or vehicle one week before left coronary artery ligation or sham surgery until the end of the experiments. After pressure–volume loop analysis, mouse hearts were harvested for histopathological (including PSR, TTC, TUNEL staining, immunohistochemistry, and immunofluorescence) and molecular analysis by western blotting and RT-PCR. In addition, neonatal rat cardiomyocytes (NRCMs), cardiac fibroblasts (CFs), and macrophages were isolated for in vitro experiments. Key Findings . RSV treatment decreased mortality and improved cardiac hemodynamics. RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF- κ B, hence alleviating infarction area, fibrosis, and cell apoptosis. RSV also inhibited expression of interleukin- (IL-) 1 β , IL-6, tumor necrosis factor- α , and IL-18 in vivo . In in vitro experiment, RSV prevented hypoxia-induced NRCM senescence and apoptosis. After inhibition of sirtuin 1 (Sirt1) by EX27, RSV failed to inhibit p53 acetylation and expression. Moreover, RSV could inhibit expression of NLRP3 and caspase 1 p20 in NRCMs, CFs, and macrophages, respectively, in in vitro experiments. Significance . Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation." @default.
• W3080701870 created "2020-09-01" @default.
• W3080701870 creator A5005935236 @default.
• W3080701870 creator A5009318195 @default.
• W3080701870 creator A5031953660 @default.
• W3080701870 creator A5033284189 @default.
• W3080701870 creator A5035765470 @default.
• W3080701870 creator A5054996803 @default.
• W3080701870 creator A5064891212 @default.
• W3080701870 creator A5077352796 @default.
• W3080701870 date "2020-08-25" @default.
• W3080701870 modified "2023-10-14" @default.
• W3080701870 title "Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation" @default.
• W3080701870 cites W1752014911 @default.
• W3080701870 cites W176636801 @default.
• W3080701870 cites W1888783223 @default.
• W3080701870 cites W1923746164 @default.
• W3080701870 cites W1952644522 @default.
• W3080701870 cites W1979657807 @default.
• W3080701870 cites W1982062664 @default.
• W3080701870 cites W1986877767 @default.
• W3080701870 cites W2019922945 @default.
• W3080701870 cites W2042419649 @default.
• W3080701870 cites W2057630805 @default.
• W3080701870 cites W2063920680 @default.
• W3080701870 cites W2076025570 @default.
• W3080701870 cites W2098635998 @default.
• W3080701870 cites W2122931119 @default.
• W3080701870 cites W2124485728 @default.
• W3080701870 cites W2140366325 @default.
• W3080701870 cites W2145190952 @default.
• W3080701870 cites W2149450314 @default.
• W3080701870 cites W2156697471 @default.
• W3080701870 cites W2158251337 @default.
• W3080701870 cites W2172019839 @default.
• W3080701870 cites W2343539326 @default.
• W3080701870 cites W2345409531 @default.
• W3080701870 cites W2401288519 @default.
• W3080701870 cites W2486445835 @default.
• W3080701870 cites W2519885630 @default.
• W3080701870 cites W2587646706 @default.
• W3080701870 cites W2588818472 @default.
• W3080701870 cites W2610404651 @default.
• W3080701870 cites W2621078115 @default.
• W3080701870 cites W2747751876 @default.
• W3080701870 cites W2752542655 @default.
• W3080701870 cites W2757940832 @default.
• W3080701870 cites W2761080014 @default.
• W3080701870 cites W2764250492 @default.
• W3080701870 cites W2765602608 @default.
• W3080701870 cites W2766557215 @default.
• W3080701870 cites W2768492618 @default.
• W3080701870 cites W2771525199 @default.
• W3080701870 doi "https://doi.org/10.1155/2020/2647807" @default.
• W3080701870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7468658" @default.
• W3080701870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32908628" @default.
• W3080701870 hasPublicationYear "2020" @default.
• W3080701870 type Work @default.
• W3080701870 sameAs 3080701870 @default.
• W3080701870 citedByCount "40" @default.
• W3080701870 countsByYear W30807018702021 @default.
• W3080701870 countsByYear W30807018702022 @default.
• W3080701870 countsByYear W30807018702023 @default.
• W3080701870 crossrefType "journal-article" @default.
• W3080701870 hasAuthorship W3080701870A5005935236 @default.
• W3080701870 hasAuthorship W3080701870A5009318195 @default.
• W3080701870 hasAuthorship W3080701870A5031953660 @default.
• W3080701870 hasAuthorship W3080701870A5033284189 @default.
• W3080701870 hasAuthorship W3080701870A5035765470 @default.
• W3080701870 hasAuthorship W3080701870A5054996803 @default.
• W3080701870 hasAuthorship W3080701870A5064891212 @default.
• W3080701870 hasAuthorship W3080701870A5077352796 @default.
• W3080701870 hasBestOaLocation W30807018701 @default.
• W3080701870 hasConcept C104317684 @default.
• W3080701870 hasConcept C126322002 @default.
• W3080701870 hasConcept C127561419 @default.
• W3080701870 hasConcept C150903083 @default.
• W3080701870 hasConcept C17991360 @default.
• W3080701870 hasConcept C190283241 @default.
• W3080701870 hasConcept C196795494 @default.
• W3080701870 hasConcept C203014093 @default.
• W3080701870 hasConcept C207001950 @default.
• W3080701870 hasConcept C2776536020 @default.
• W3080701870 hasConcept C2776816829 @default.
• W3080701870 hasConcept C2776914184 @default.
• W3080701870 hasConcept C2777209026 @default.
• W3080701870 hasConcept C502942594 @default.
• W3080701870 hasConcept C522857546 @default.
• W3080701870 hasConcept C541997718 @default.
• W3080701870 hasConcept C55493867 @default.
• W3080701870 hasConcept C71924100 @default.
• W3080701870 hasConcept C86803240 @default.
• W3080701870 hasConcept C95444343 @default.
• W3080701870 hasConcept C98274493 @default.
• W3080701870 hasConceptScore W3080701870C104317684 @default.
• W3080701870 hasConceptScore W3080701870C126322002 @default.
• W3080701870 hasConceptScore W3080701870C127561419 @default.
• W3080701870 hasConceptScore W3080701870C150903083 @default.

• next