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- W3080703100 abstract "This chapter discusses hydrolytic and dehydratase enzymes, providing synthesis of (s)-3-(4-chlorophenyl)-4-cyanobutanoic acid by a mutant nitrilase. It establishes an in vivo enzymatic reaction performed by a triple mutant with high activity and stereoselectivity for the production of active 2. This triple mutant comes from the Synechocystis sp. strain PCC 6803 and was engineered by directed evolution. Almac selectAZyme™ nitrilase technology was used to access hydroxyphenylacetic acid derivative 2 starting from cyanohydrin intermediate 1. Initial screening was carried out with pre-formed cyanohydrin 1 to identify nitrilases with the desired activity and selectivity. Almac has a wide range of nitrilases (~200) in stock that can be used for the hydrolysis of nitriles to carboxylic acids under mild conditions (neutral buffer, 20–30 ∘C)." @default.
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- W3080703100 date "2020-08-21" @default.
- W3080703100 modified "2023-10-18" @default.
- W3080703100 title "Hydrolytic and Dehydratase Enzymes" @default.
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- W3080703100 doi "https://doi.org/10.1002/9781119487043.ch9" @default.
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