Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080734295> ?p ?o ?g. }
- W3080734295 abstract "Abstract Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), are involved in mediating fundamental innate antimicrobial immunity by promoting the release of type I interferons (IFNs) and other inflammatory cytokines. Accumulating evidence suggests that the activation of the cGAS-STING axis is critical for antitumor immunity. The downstream cytokines regulated by cGAS-STING, especially type I IFNs, serve as bridges connecting innate immunity with adaptive immunity. Accordingly, a growing number of studies have focused on the synthesis and screening of STING pathway agonists. However, chronic STING activation may lead to a protumor phenotype in certain malignancies. Hence, the cGAS-STING signaling pathway must be orchestrated properly when STING agonists are used alone or in combination. In this review, we discuss the dichotomous roles of the cGAS-STING pathway in tumor development and the latest advances in the use of STING agonists." @default.
- W3080734295 created "2020-09-01" @default.
- W3080734295 creator A5002608004 @default.
- W3080734295 creator A5003919991 @default.
- W3080734295 creator A5013646908 @default.
- W3080734295 creator A5031338308 @default.
- W3080734295 creator A5048881400 @default.
- W3080734295 creator A5063346114 @default.
- W3080734295 creator A5074967184 @default.
- W3080734295 creator A5075883718 @default.
- W3080734295 creator A5076699095 @default.
- W3080734295 creator A5084508812 @default.
- W3080734295 date "2020-08-27" @default.
- W3080734295 modified "2023-10-18" @default.
- W3080734295 title "Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy" @default.
- W3080734295 cites W1124150750 @default.
- W3080734295 cites W1514540900 @default.
- W3080734295 cites W1522977578 @default.
- W3080734295 cites W1630358515 @default.
- W3080734295 cites W1667606852 @default.
- W3080734295 cites W1673416641 @default.
- W3080734295 cites W1776390480 @default.
- W3080734295 cites W1798681852 @default.
- W3080734295 cites W1866003637 @default.
- W3080734295 cites W1897605380 @default.
- W3080734295 cites W1898887656 @default.
- W3080734295 cites W1905337938 @default.
- W3080734295 cites W1933048492 @default.
- W3080734295 cites W1933156295 @default.
- W3080734295 cites W1963521487 @default.
- W3080734295 cites W1963774361 @default.
- W3080734295 cites W1968178474 @default.
- W3080734295 cites W1968512491 @default.
- W3080734295 cites W1978064890 @default.
- W3080734295 cites W1984539398 @default.
- W3080734295 cites W1987604182 @default.
- W3080734295 cites W1993860509 @default.
- W3080734295 cites W1994826332 @default.
- W3080734295 cites W1994993231 @default.
- W3080734295 cites W1995744610 @default.
- W3080734295 cites W2000179708 @default.
- W3080734295 cites W2010417927 @default.
- W3080734295 cites W2012855647 @default.
- W3080734295 cites W2016131266 @default.
- W3080734295 cites W2020210109 @default.
- W3080734295 cites W2021364411 @default.
- W3080734295 cites W2026830644 @default.
- W3080734295 cites W2031182394 @default.
- W3080734295 cites W2035232303 @default.
- W3080734295 cites W2042288276 @default.
- W3080734295 cites W2042433863 @default.
- W3080734295 cites W2046640968 @default.
- W3080734295 cites W2046713164 @default.
- W3080734295 cites W2050733784 @default.
- W3080734295 cites W2051761998 @default.
- W3080734295 cites W2058277625 @default.
- W3080734295 cites W2066586758 @default.
- W3080734295 cites W2072118838 @default.
- W3080734295 cites W2077813812 @default.
- W3080734295 cites W2080350014 @default.
- W3080734295 cites W2091144643 @default.
- W3080734295 cites W2093268266 @default.
- W3080734295 cites W2094992498 @default.
- W3080734295 cites W2095617425 @default.
- W3080734295 cites W2098854209 @default.
- W3080734295 cites W2099610218 @default.
- W3080734295 cites W2114085082 @default.
- W3080734295 cites W2118421843 @default.
- W3080734295 cites W2118451644 @default.
- W3080734295 cites W2119864130 @default.
- W3080734295 cites W2120426523 @default.
- W3080734295 cites W2120532459 @default.
- W3080734295 cites W2121985312 @default.
- W3080734295 cites W2132413371 @default.
- W3080734295 cites W2134007339 @default.
- W3080734295 cites W2134644569 @default.
- W3080734295 cites W2142115645 @default.
- W3080734295 cites W2142433291 @default.
- W3080734295 cites W2144277227 @default.
- W3080734295 cites W2144697790 @default.
- W3080734295 cites W2151070118 @default.
- W3080734295 cites W2154171253 @default.
- W3080734295 cites W2158631358 @default.
- W3080734295 cites W2167261450 @default.
- W3080734295 cites W2168169019 @default.
- W3080734295 cites W2168252967 @default.
- W3080734295 cites W2171745628 @default.
- W3080734295 cites W2173816666 @default.
- W3080734295 cites W2179058242 @default.
- W3080734295 cites W2190388875 @default.
- W3080734295 cites W2220279767 @default.
- W3080734295 cites W2232266376 @default.
- W3080734295 cites W2237126693 @default.
- W3080734295 cites W2237797200 @default.
- W3080734295 cites W2280100400 @default.
- W3080734295 cites W2293022769 @default.
- W3080734295 cites W2296705508 @default.
- W3080734295 cites W2322522340 @default.
- W3080734295 cites W2322805566 @default.
- W3080734295 cites W2340906209 @default.