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- W3080738419 abstract "Abstract Activation and migration of endogenous mesenchymal stromal cells (MSCs) are critical for bone regeneration. Here, we report a combinational peptide screening strategy for rapid discovery of ligands that not only bind strongly to osteogenic progenitor cells (OPCs) but also stimulate osteogenic cell Akt signaling in those OPCs. Two lead compounds are discovered, YLL3 and YLL8, both of which increase osteoprogenitor osteogenic differentiation in vitro . When given to normal or osteopenic mice, the compounds increase mineral apposition rate, bone formation, bone mass, and bone strength, as well as expedite fracture repair through stimulated endogenous osteogenesis. When covalently conjugated to alendronate, YLLs acquire an additional function resulting in a “tri-functional” compound that: (i) binds to OPCs, (ii) targets bone, and (iii) induces “pro-survival” signal. These bone-targeted, osteogenic peptides are well suited for current tissue-specific therapeutic paradigms to augment the endogenous osteogenic cells for bone regeneration and the treatment of bone loss." @default.
- W3080738419 created "2020-09-01" @default.
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- W3080738419 date "2020-08-27" @default.
- W3080738419 modified "2023-10-13" @default.
- W3080738419 title "Identification of osteogenic progenitor cell-targeted peptides that augment bone formation" @default.
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- W3080738419 doi "https://doi.org/10.1038/s41467-020-17417-9" @default.
- W3080738419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7453024" @default.
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