FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080768166> ?p ?o ?g. }

• W3080768166 endingPage "400" @default.
• W3080768166 startingPage "400" @default.
• W3080768166 abstract "400 Objectives: Alzheimer’s disease (AD) is a major health challenge in our aging society. An improved understanding of its underlying pathological mechanisms is urgently needed to enable the development of effective treatments. Postmortem findings indicate that tau pathology emerges decades before amyloid pathology, appearing first in the brainstem; in particular in the locus coeruleus (LC), a small nucleus that is the source of most of the brain’s norepinephrine (NE). Although very little is known about how the NE system changes during normal aging and its potential role in progression of preclinical stages of AD, our preliminary data using (S,S)-[11C]MRB ([11C]MRB) have documented an age-related decline in NE transporters (NET) availability starting in middle age, suggesting in vivo NET availability is a sensitive biomarker for aging and for changes during the preclinical stages of AD. In addition to the age effect, this report investigated the potential gender and ethnicity effects on NET availability. Methods: Dynamic [11C]MRB images of healthy subjects were acquired for 120 min and individual structure MRI images were acquired for co-registration purposes. The segmentation of cortical and subcortical ROIs was automatically established via FreeSurfer (https://surfer.nmr.mgh.harvard.edu/) based on the template MRI atlas (FS2005). Left and right olfactory (Ofac) regions were also generated using the Destrieux Atlas. With Firevoxel developed at NYU (https://wp.nyu.edu/Firevoxel), PET, MRI, and the FS atlas images of each individual were coregistered using a mutual information algorithm with autofocus transformation that was tested and validated. Dynamic regional time-activity curves (TAC) were generated and MRTM2 was selected as the modeling method. Binding potential (BPND, a measure of specific binding with respect to non-displaceable uptake) values were automatically calculated, and tested by various starting time, parameter k2’ and using two potential reference regions (caudate & occipital, low NET regions), for comparison and validation purposes. Annual percent change (APC) of regional BPND values was calculated based on linear regression (APC = 100 × (em - 1), m is the slope) and effects of age, gender and ethnicity on the NET-MRB binding were evaluated. Results: Data presented here were based on t2* 20 min and k2’ 0.021 min-1 with occi as the reference region. For all HC (N=31), with both genders and all race included, the NET availability decline can be observed; e.g., -0.4%/yr for BS & ROfac. However, in gender-separated group analysis [M (N=19, age range: 23-55, avg=36.2±9.9) and F (N=12, age range 25-54, avg= 36.6±9.0)], while BPND values were not significantly different, there was a significant gender effect for APC (P <0.01) with decline rates faster for M (e.g., -0.8, -0.6, -0.5, & -0.4%/yr for TH, RAmyg, ROfac, & Hip, respectively), and significant decline starting from mid 30 (p<0.001). Gender effects were also observed in the group-level analyses in all white (N=16, 11M) and in all AA subgroups (N=14, 7M) with the decline rate faster for M than F, but APC difference did not reach significance (may be due to sample size and age range not completely matched). Interestingly, out of all investigated brain ROIs (16), avg BPND values of each ROI from AA (N=14, avg age 34±7) were consistently higher than those from white subjects (N=12, avg age 35±8)(P<0.000). However, the decline rate was consistently higher for AA than for white subjects (P<0.00001), e.g., the decline rate for AA-M: -3%/yr in LTH & RAmyg and over -1%/yr in BS & ROfac, and for AA-F: -2%/yr in BS & Ofac. Conclusions: Compared to our previous age-related study of dopamine transporter (DAT), NET exhibited a faster decline rate than DAT. In addition to our previously determined age effect on MRB-NET binding, this report further reveals the role of gender and ethnicity effects on NET availability. A bigger sample size is warranted to investigate their effects on the NET availability." @default.
• W3080768166 created "2020-09-01" @default.
• W3080768166 creator A5016433401 @default.
• W3080768166 creator A5023853659 @default.
• W3080768166 creator A5048872884 @default.
• W3080768166 creator A5062895804 @default.
• W3080768166 creator A5087752085 @default.
• W3080768166 date "2020-05-01" @default.
• W3080768166 modified "2023-09-24" @default.
• W3080768166 title "Age, Gender, and Ethnicity Effects on NET Availability in Humans using [11C]MRB" @default.
• W3080768166 hasPublicationYear "2020" @default.
• W3080768166 type Work @default.
• W3080768166 sameAs 3080768166 @default.
• W3080768166 citedByCount "0" @default.
• W3080768166 crossrefType "journal-article" @default.
• W3080768166 hasAuthorship W3080768166A5016433401 @default.
• W3080768166 hasAuthorship W3080768166A5023853659 @default.
• W3080768166 hasAuthorship W3080768166A5048872884 @default.
• W3080768166 hasAuthorship W3080768166A5062895804 @default.
• W3080768166 hasAuthorship W3080768166A5087752085 @default.
• W3080768166 hasConcept C126838900 @default.
• W3080768166 hasConcept C142724271 @default.
• W3080768166 hasConcept C143409427 @default.
• W3080768166 hasConcept C15744967 @default.
• W3080768166 hasConcept C169760540 @default.
• W3080768166 hasConcept C176233148 @default.
• W3080768166 hasConcept C2775842073 @default.
• W3080768166 hasConcept C2778514916 @default.
• W3080768166 hasConcept C2780972224 @default.
• W3080768166 hasConcept C2781197716 @default.
• W3080768166 hasConcept C513476851 @default.
• W3080768166 hasConcept C55493867 @default.
• W3080768166 hasConcept C60592354 @default.
• W3080768166 hasConcept C71924100 @default.
• W3080768166 hasConcept C86803240 @default.
• W3080768166 hasConceptScore W3080768166C126838900 @default.
• W3080768166 hasConceptScore W3080768166C142724271 @default.
• W3080768166 hasConceptScore W3080768166C143409427 @default.
• W3080768166 hasConceptScore W3080768166C15744967 @default.
• W3080768166 hasConceptScore W3080768166C169760540 @default.
• W3080768166 hasConceptScore W3080768166C176233148 @default.
• W3080768166 hasConceptScore W3080768166C2775842073 @default.
• W3080768166 hasConceptScore W3080768166C2778514916 @default.
• W3080768166 hasConceptScore W3080768166C2780972224 @default.
• W3080768166 hasConceptScore W3080768166C2781197716 @default.
• W3080768166 hasConceptScore W3080768166C513476851 @default.
• W3080768166 hasConceptScore W3080768166C55493867 @default.
• W3080768166 hasConceptScore W3080768166C60592354 @default.
• W3080768166 hasConceptScore W3080768166C71924100 @default.
• W3080768166 hasConceptScore W3080768166C86803240 @default.
• W3080768166 hasLocation W30807681661 @default.
• W3080768166 hasOpenAccess W3080768166 @default.
• W3080768166 hasPrimaryLocation W30807681661 @default.
• W3080768166 hasRelatedWork W1978227671 @default.
• W3080768166 hasRelatedWork W2018379072 @default.
• W3080768166 hasRelatedWork W2145633159 @default.
• W3080768166 hasRelatedWork W2362236180 @default.
• W3080768166 hasRelatedWork W2377305776 @default.
• W3080768166 hasRelatedWork W3195152711 @default.
• W3080768166 hasRelatedWork W2189424367 @default.
• W3080768166 hasRelatedWork W2439059768 @default.
• W3080768166 hasVolume "61" @default.
• W3080768166 isParatext "false" @default.
• W3080768166 isRetracted "false" @default.
• W3080768166 magId "3080768166" @default.
• W3080768166 workType "article" @default.